Discovering And Targeting Genes Regulating Skeletal Muscle Function, Metabolism, And Adaptations To Exercise Interventions
Funder
National Health and Medical Research Council
Funding Amount
$431,000.00
Summary
Muscle wasting and decreased in mitochondrial function due to ageing or lack of physical activity are associated with reduced quality of life. The overarching aim is to develop a unique research program focusing on targeting specific genes, and to discover novel genes regulating muscle wasting and mitochondrial (dis)function. I anticipate this approach to assist in the development of targeted and personalised prevention and therapy for diseases associated with muscle (dis)function.
Central Blood Pressure: Physiology And Clinical Application
Funder
National Health and Medical Research Council
Funding Amount
$459,270.00
Summary
Current methods used by doctors to measure blood pressure (BP) have many limitations that could result in incorrect diagnosis and inappropriate treatment of high BP (hypertension). This research program will determine the clinical usefulness of new methods to diagnose and treat people with high BP. The underlying mechanisms contributing to high BP will also be examined. The findings will lead to improved ways to identify and more effectively manage people with high BP.
A pressure pulse may be felt at the wrist with every heart beat. New technology allows the analysis of this pulse and provides information that may help doctors make decisions about a patients risk related to blood pressure as well as the effect of drug treatment. The research aims to determine the clinical significance of pressure pulse analysis at rest and during light exercise. It is expected that the new technology will improve the way people with high blood pressure are treated.
Characterisation Of Sub-clinical Cardiac Dysfunction Using Novel Cardiac Exercise Imaging
Funder
National Health and Medical Research Council
Funding Amount
$429,552.00
Summary
Heart failure is caused by heart muscle weakness and is associated with reduced quality of life and survival. Identification of heart failure in its earliest stages provides clinicians with an opportunity to institute preventative measures and prevent patients from developing symptoms. This project utilises novel ultrasound and magnetic resonance imaging techniques performed during exercise to identify heart muscle weakness at its earliest stage.
Using Technology Towards Effective Self-management Of Fall Risk In Older Adults
Funder
National Health and Medical Research Council
Funding Amount
$463,652.00
Summary
Our society’s population is ageing rapidly. Accidental falls are a major contributor to the burden of disease in older people and a major public health problem. In my research program, I use technology to find feasible solutions to deliver complex tailored interventions to prevent falls and support healthy ageing through self-management. My approach has potential to have major, lasting public health benefits by reducing falls and advancing healthy ageing at a low cost for the health care sector.
Innovative Approaches To Implement Falls Prevention Strategies In Older People
Funder
National Health and Medical Research Council
Funding Amount
$408,388.00
Summary
The overall aim is to reduce the number of falls and improve the quality of life of older citizens while containing the burden on carers and on the healthcare system. The project will combine research and technology, by partnering with Philips Research. It will follow three main streams, i.e. translation into practice using an “Information and Communication Technology” (ICT) approach, and finally implementation and dissemination.