Evaluating “Standing Tall” – An Engaging Home-based Exercise Program Using Mobile Technology For Maximizing Long-term Adherence And Preventing Falls In Older People: Randomized Controlled Trial
Funder
National Health and Medical Research Council
Funding Amount
$791,081.00
Summary
Current evidence suggests that older people have to exercise for two hours per week for six months to prevent falls, with a strong focus on balance exercises. We have developed and tested an engaging home-based balance training program delivered through mobile (tablet) technology, called ‘Standing Tall’. We propose a randomised controlled trial to examine the effectiveness of our program for preventing falls in 500 community-dwelling older people, in addition to adherence- and cost-analyses.
Glycan-glycan Interactions Between Bacterial Pathogens And Host Cells: A Novel Mechanism Of Bacterial Adherence, A New Opportunity For Strategies To Treat And Prevent Disease And A New Paradigm In Interactions Between Macromolecules.
Funder
National Health and Medical Research Council
Funding Amount
$1,059,344.00
Summary
Cell surface carbohydrates are ubiquitous throughout nature. Human cell surface carbohydrates are specifically targeted by microbial proteins. These interactions are crucial in causing disease. We have recently shown that the carbohydrates on our cells and those on pathogenic bacteria can interact with one another. Understanding the nature and role of these newly discovered interactions may lead to strategies to block them via new drugs and vaccines.
Increasing Engagement With Online Psychosocial Programs To Improve Mental Health In The Community
Funder
National Health and Medical Research Council
Funding Amount
$352,317.00
Summary
Online therapy programs have a strong evidence base in reducing mental health symptoms. However, take-up of these programs in the community is limited, and low adherence to these programs limits their impact. This project is a randomised controlled trial testing a novel approach to increasing uptake and adherence to psychosocial online programs, involving acceptance facilitation. Results will inform the dissemination of evidence-based psychosocial programs for a range of health conditions.
CareTrack Aged: Appropriate Care Delivered To Australians Living In Residential Aged Care
Funder
National Health and Medical Research Council
Funding Amount
$1,157,722.00
Summary
Given Australia’s rapidly ageing population, keeping up with future demands and maintaining quality of care in residential aged care facilities (RACF) is vital. This study will assess whether care delivered is consistent with the evidence in 15 conditions that are frequently managed in RACFs. These will include delirium, dementia, depression, pain management and medication management. We will also assess the quality of life of residents in RACFs.
Quadruple UltrA-low-dose TReamenT For HypErTension - QUARTET
Funder
National Health and Medical Research Council
Funding Amount
$1,242,865.00
Summary
High blood pressure is common and a major cause of heart disease and stroke. While many people with hypertension are on some treatment, in over half blood pressure targets are not reached and their high blood pressure is hence uncontrolled. In this research we investigate whether an approach that combines 4 types of blood pressure lowering medications at quarter doses into one pill, may be a more effective way of controlling blood pressure and doing this with few side effects.
TEXTMEDS – TEXT Messages To Improve MEDication Adherence And Secondary Prevention
Funder
National Health and Medical Research Council
Funding Amount
$1,406,875.00
Summary
TEXTMEDS will evaluate a highly innovative strategy to improve cardiovascular disease secondary prevention using cheap and widely available mobile phone technology. TEXTMEDS is a randomised controlled trial of 1400 patients with acute coronary syndrome that will examine the effect of a semi-personalised secondary prevention support program sent via mobile phone text message on the proportion taking appropriate medications for the secondary prevention of cardiovascular disease and on cardiovascul ....TEXTMEDS will evaluate a highly innovative strategy to improve cardiovascular disease secondary prevention using cheap and widely available mobile phone technology. TEXTMEDS is a randomised controlled trial of 1400 patients with acute coronary syndrome that will examine the effect of a semi-personalised secondary prevention support program sent via mobile phone text message on the proportion taking appropriate medications for the secondary prevention of cardiovascular disease and on cardiovascular risk factors levels (e.g. cholesterol).Read moreRead less
Asking The Right Questions About Attention-deficit Hyperactivity Disorder In Children: A Cluster Randomized Controlled Trial
Funder
National Health and Medical Research Council
Funding Amount
$484,930.00
Summary
This study will evaluate the impact of a novel question prompt list (QPL) for parents of children with attention-deficit hyperactivity disorder (ADHD), on their communication with their child’s doctor, and health outcomes such as adherence. The QPL aims to increase parent question asking and information sharing between clinicians and parents; improve parents’ ADHD knowledge across the developmental lifespan of their child; and thus improve adherence to medication in children with ADHD.
Does Manipulation Of Arterial Shear Stress Enhance Cerebrovascular Function And Cognition In The Aging Brain?
Funder
National Health and Medical Research Council
Funding Amount
$707,914.00
Summary
Globally, 9.2 million less cases of dementia could result from delaying it by as little as 12 months. We will assess the impact, on artery health and cognition, of a novel exercise intervention involving enhanced patterns of brain blood flow and arterial shear stress during exercise, stimuli which should optimise cerebrovascular health. Given that pharmacological approaches to prevention are ineffective, this project has the potential to address the future impact of this common and debilitating ....Globally, 9.2 million less cases of dementia could result from delaying it by as little as 12 months. We will assess the impact, on artery health and cognition, of a novel exercise intervention involving enhanced patterns of brain blood flow and arterial shear stress during exercise, stimuli which should optimise cerebrovascular health. Given that pharmacological approaches to prevention are ineffective, this project has the potential to address the future impact of this common and debilitating disease in Australians.Read moreRead less
Clinical Effectiveness Of Aspirin In Healing Chronic Venous Leg Ulcers: A Randomised Double-blinded Placebo-controlled Trial
Funder
National Health and Medical Research Council
Funding Amount
$791,980.00
Summary
Chronic venous leg ulcers (VLU) are a common and costly problem. People with chronic wounds found on the ankles and legs can be spontaneous or occur after minor trauma, they are often painful and ooze fluid. The burden is expected to rise with an ageing population and growing epidemic of diabetes and obesity which will increase challenges for clinicians. We will perform a clinical trial to see if aspirin plus 3 layer compression in people with venous leg ulcers heal more quickly.
A COMMUNITY BASED STRENGTH TRAINING PROGRAM TO IMPROVE WORK TASK PERFORMANCE IN YOUNG ADULTS WITH DOWN SYNDROME
Funder
National Health and Medical Research Council
Funding Amount
$180,649.00
Summary
This study will compare the outcomes of a 10 week twice a week community-based weight training program for young adults with Down syndrome with an art program. It will establish if a student-led exercise program can improve their performance of work tasks and their activity levels. Should the program prove beneficial, we aim to achieve the long-term outcome of exercise being implemented as a sustainable, inclusive recreation option for this group.