AVERT-DOSE (Determining Optimal Early Rehabilitation After StrokE): A Multi-arm Covariate-adjusted, Response-adaptive Randomised Controlled Trial
Funder
National Health and Medical Research Council
Funding Amount
$4,359,564.00
Summary
AVERT-DOSE is an international, investigator-led clinical trial, developed in Australia but recruiting >2500 patients from 6 countries around the world. In this trial we will establish the optimal model of early mobility rehabilitation for people with acute stroke. The protocols we develop will be suitable for adoption in clinical practice in developed and developing countries and help reduce the unacceptably high personal and community burden of stroke-related disability world wide.
Reduction Of Breast Lymphoedema Symptoms Secondary To Breast Cancer: A Randomised Controlled Trial
Funder
National Health and Medical Research Council
Funding Amount
$600,395.00
Summary
Breast lymphoedema is a consequence of treatment for breast cancer that is not typically discussed, despite more than 1/3 of women with lymphoedema reporting symptoms in the breast. To date, no study has investigated the impact of exercise on breast lymphoedema symptoms. The aim of this study is to determine if a general exercise program is safe, acceptable and effective in reducing symptoms for women with breast lymphoedema.
Clinical Trial Of Rehabilitation After Ankle Fracture
Funder
National Health and Medical Research Council
Funding Amount
$443,348.00
Summary
Over 20,500 Australians fracture their ankle each year. Initially the fracture is managed with cast immobilisation, sometimes after surgery. Pain, stiffness, weakness and swelling are disabling consequences of fracture and cast immobilisation, and can prevent return to work and sport. This trial will determine the effects and cost of rehabilitation (a physiotherapy exercise program) implemented after cast removal, and enable provision of evidence-based treatment for this very common problem.
Improving Mobility After Traumatic Brain Injury With Ballistic Strength Training
Funder
National Health and Medical Research Council
Funding Amount
$661,430.00
Summary
Traumatic Brain Injury (TBI) is the leading cause of disability amongst young adults, many of whom have difficulty walking. Muscle weakness is the main cause of these walking problems, but previous trials have failed to improve walking performance. We have developed new strengthening exercises which focus on how quickly the muscles can contract, rather than just how strong they are. These exercises can increase muscle power by 60-74% and are likely to improve people’s ability to walk.
Improving Arm Function After Stroke Using Task Specific Training
Funder
National Health and Medical Research Council
Funding Amount
$832,597.00
Summary
85% of the 15 million people in the world annually who have a stroke cannot use their arm for basic tasks like eating and toileting. With usual health care services, 60% of stroke survivors still have non-functional arms 6 months after stroke. More effective treatments are needed. Task-specific training may improve arm and hand function more than usual care. We will conduct a multicentre randomised controlled trial to test whether task-specific training is more effective than usual care.