Health-related physical activity: Psychological determinants, consequences, and experimental interventions. Increasingly sedentary lifestyles and physical inactivity constitute a worldwide health problem. Despite well-known benefits of physical activity, preventive-medicine interventions have had limited success. Instead, we propose an innovative psychological approach, emphasising quality of subjective experience (flow), motivation, physical self-concept, and the transtheoretical model of beha ....Health-related physical activity: Psychological determinants, consequences, and experimental interventions. Increasingly sedentary lifestyles and physical inactivity constitute a worldwide health problem. Despite well-known benefits of physical activity, preventive-medicine interventions have had limited success. Instead, we propose an innovative psychological approach, emphasising quality of subjective experience (flow), motivation, physical self-concept, and the transtheoretical model of behavioural change. We propose psychological determinants of physical activity and a new experimental intervention to significantly enhance health-related physical activity. The research breaks new theoretical ground, extending and integrating different theoretical perspectives, offering a synergy between qualitative and quantitative research traditions, and providing practical benefits to mental and physical health and to quality of life.Read moreRead less
Psychological determinants of physical activity across the life span and critical life-stage transitions: Cross-sectional, longitudinal causal modelling, and experimental interventions. Increasingly, sedentary lifestyles and physical inactivity are major worldwide health problems. Despite well-established health benefits of physical activity, existing medical-oriented interventions have had limited effects on increasing population-levels of activity. We propose a psychological approach, emphasiz ....Psychological determinants of physical activity across the life span and critical life-stage transitions: Cross-sectional, longitudinal causal modelling, and experimental interventions. Increasingly, sedentary lifestyles and physical inactivity are major worldwide health problems. Despite well-established health benefits of physical activity, existing medical-oriented interventions have had limited effects on increasing population-levels of activity. We propose a psychological approach, emphasizing quality of subjective experience (flow), motivation, physical self-concept, and the transtheoretical model of change. We will evaluate psychological determinants of health-related physical activity and implement experimental physical activity enhancing interventions at two critical life stages: for late-adolescents and older Australians. The proposal advances theory and methodology in a National Research Priority area, providing practical solutions to important societal problems with socioeconomic benefits for Australia.Read moreRead less
Regulatory mechanisms in skeletal muscle lipid hydrolysis. The regulation of intramuscular triglyceride (fat) utilisation by human skeletal muscle is largely unknown. Our contention is that the specialized protein enzyme, hormone sensitive lipase (HSL), has a fundamental role in intramuscular triacylglycerol utilisation and is regulated by both intramuscular levels of key metabolites and circulating hormone concentrations. We also propose control points subsequent to HSL activation are important ....Regulatory mechanisms in skeletal muscle lipid hydrolysis. The regulation of intramuscular triglyceride (fat) utilisation by human skeletal muscle is largely unknown. Our contention is that the specialized protein enzyme, hormone sensitive lipase (HSL), has a fundamental role in intramuscular triacylglycerol utilisation and is regulated by both intramuscular levels of key metabolites and circulating hormone concentrations. We also propose control points subsequent to HSL activation are important for triglyceride hydrolysis. Our proposed project examines these factors and will enhance our understanding of the regulation of muscle fat use, thereby leading to potential metabolic strategies (nutritional, pharmacological) that enhance skeletal muscle function at rest and during exercise.Read moreRead less
The role of intracellular calcium in fibre-type specific gene expression in skeletal muscle. Muscles contain different fibre types whose composition can be changed by activity. The aim of this proposal is to identify the intracellular mechanisms which control fibre type. Our hypothesis is that different patterns of intracellular calcium determine the pattern of gene expression which determines fibre type. Understanding how gene expression is regulated is a central issue in biology.
Biological Role of Contraction-Induced Heat Shock Protein Expression. It is well known that mammalian skeletal muscle increases its expression of a group of highly conserved proteins, the heat shock proteins (HSP) in response to repeated contraction. However, the biological role of this expression is unclear. The aim of this project is to determine the biological role of contraction-induced HSP expression. We expect to show that HSP synthesis in response to exercise has three major roles; 1) to ....Biological Role of Contraction-Induced Heat Shock Protein Expression. It is well known that mammalian skeletal muscle increases its expression of a group of highly conserved proteins, the heat shock proteins (HSP) in response to repeated contraction. However, the biological role of this expression is unclear. The aim of this project is to determine the biological role of contraction-induced HSP expression. We expect to show that HSP synthesis in response to exercise has three major roles; 1) to act to repair damaged proteins in recovery from muscle injury 2) to act as a "molecular motor" to translocate proteins from one region of a muscle cell to another and 3) to be released into the circulation in order to act as a central signal to activate immune cells. Such a project will be significant because it will allow for a fundamental understanding as to why these proteins are produced in response to exercise. We expect to enhance our understanding of fundamental cell biology.Read moreRead less
Intracellular calcium in intact muscle during fatigue and stretch-induced damage. Confocal microscopes can investigate intact tissues during normal function. We will develop and apply this novel approach to muscle. We expect this new approach to become a fundamental new tool for exploring muscle function under near normal conditions. Muscle pain and weakness are common disabilities in humans and we expect this new approach to provide insights into the causes and treatment of these common cond ....Intracellular calcium in intact muscle during fatigue and stretch-induced damage. Confocal microscopes can investigate intact tissues during normal function. We will develop and apply this novel approach to muscle. We expect this new approach to become a fundamental new tool for exploring muscle function under near normal conditions. Muscle pain and weakness are common disabilities in humans and we expect this new approach to provide insights into the causes and treatment of these common conditions.Read moreRead less
Embodied Virtues and Expertise. The Project will provide a theoretical framework for understanding expertise. Crucially, the framework will provide an account that explains the motivation of experts, and allows for the virtues of experts to be analysed and promoted. The framework will thus fill a perceived gap in professional pedagogical disciplines such as Education, Nursing Education, and Medicine, in which the concept of expertise is central, but for which an adequate theoretical framework of ....Embodied Virtues and Expertise. The Project will provide a theoretical framework for understanding expertise. Crucially, the framework will provide an account that explains the motivation of experts, and allows for the virtues of experts to be analysed and promoted. The framework will thus fill a perceived gap in professional pedagogical disciplines such as Education, Nursing Education, and Medicine, in which the concept of expertise is central, but for which an adequate theoretical framework of expertise is lacking. Academics and practitioners from these disciplines will participate in conferences and workshops run under the Project.Read moreRead less
Reducing the fat burden: Identification of novel cellular and molecular targets for alleviating skeletal muscle insulin resistance. Insulin resistance and the associated consequences are a major public health problem in Australia and cost the healthcare system >$1.1 billion/year. Exercise training and thiaziolidinedione (TZD) treatment are therapies that partially ameliorate insulin resistance through distinct and independent mechanisms. However, neither intervention represents a viable long-ter ....Reducing the fat burden: Identification of novel cellular and molecular targets for alleviating skeletal muscle insulin resistance. Insulin resistance and the associated consequences are a major public health problem in Australia and cost the healthcare system >$1.1 billion/year. Exercise training and thiaziolidinedione (TZD) treatment are therapies that partially ameliorate insulin resistance through distinct and independent mechanisms. However, neither intervention represents a viable long-term strategy: exercise training has low compliance, while chronic TZD use is associated with several adverse side effects (edema, weight gain etc.). We will investigate the metabolic, cellular and molecular mechanisms by which these therapies each exert their positive effect on insulin action with the aim of identifying novel targets for future drug interventions. Read moreRead less
Intracellular localisation of insulin signalling proteins in human skeletal muscle following exercise. The metabolic action of insulin in skeletal muscle is enhanced by exercise, but the underlying mechanisms mediating this are unknown. Insulin receptor substrate proteins are key mediators in the intracellular insulin signalling pathway and play a central role in regulating many metabolic events. Our aim is to examine the hypothesis that exercise induces a novel subcellular redistribution of the ....Intracellular localisation of insulin signalling proteins in human skeletal muscle following exercise. The metabolic action of insulin in skeletal muscle is enhanced by exercise, but the underlying mechanisms mediating this are unknown. Insulin receptor substrate proteins are key mediators in the intracellular insulin signalling pathway and play a central role in regulating many metabolic events. Our aim is to examine the hypothesis that exercise induces a novel subcellular redistribution of these insulin receptor substrate proteins in skeletal muscle, such that the metabolic action of insulin is enhanced. Elucidating the mechanisms whereby exercise enhances insulin action underpins the development of new treatments and therapies with the aim of improving skeletal muscle function in health and disease.Read moreRead less
Context, Judgement and Informal Learning at Work: An Investigation of Factors Crucial for Enhancing Performance. This project investigates learning that enables people to perform well the demanding aspects of their occupations. Detailed case studies of critical incidents in a range of workplaces will be constructed and the learning or otherwise by key players involved in these incidents will be elucidated and analysed. These findings will test and refine a theory of learning at work that concept ....Context, Judgement and Informal Learning at Work: An Investigation of Factors Crucial for Enhancing Performance. This project investigates learning that enables people to perform well the demanding aspects of their occupations. Detailed case studies of critical incidents in a range of workplaces will be constructed and the learning or otherwise by key players involved in these incidents will be elucidated and analysed. These findings will test and refine a theory of learning at work that conceptualises it, at its best, as a growing capacity to make appropriate context-sensitive judgements. Developing a sound theory of workplace learning is very important because, though it is currently a major policy focus, received theories are of limited explanatory value.Read moreRead less