Does Manipulation Of Arterial Shear Stress Enhance Cerebrovascular Function And Cognition In The Aging Brain?
Funder
National Health and Medical Research Council
Funding Amount
$707,914.00
Summary
Globally, 9.2 million less cases of dementia could result from delaying it by as little as 12 months. We will assess the impact, on artery health and cognition, of a novel exercise intervention involving enhanced patterns of brain blood flow and arterial shear stress during exercise, stimuli which should optimise cerebrovascular health. Given that pharmacological approaches to prevention are ineffective, this project has the potential to address the future impact of this common and debilitating ....Globally, 9.2 million less cases of dementia could result from delaying it by as little as 12 months. We will assess the impact, on artery health and cognition, of a novel exercise intervention involving enhanced patterns of brain blood flow and arterial shear stress during exercise, stimuli which should optimise cerebrovascular health. Given that pharmacological approaches to prevention are ineffective, this project has the potential to address the future impact of this common and debilitating disease in Australians.Read moreRead less
Can Exercise Delay Transition To Active Therapy In Men With Low Grade Prostate Cancer? A Multi-Centre Randomized Controlled Trial.
Funder
National Health and Medical Research Council
Funding Amount
$604,429.00
Summary
Prostate cancer overdiagnosis is associated with increased rates of overtreatment and associated morbidity. Although nearly half of Australian men diagnosed with low risk prostate cancer are managed with active surveillance there are no established recommendations for slowing disease progression and delaying transition to active treatment. The proposed study would be the first to determine the efficacy of a comprehensive exercise program during active surveillance for prostate cancer.
Atrial Remodelling And Risk Of Arrhythmias In Endurance Athletes
Funder
National Health and Medical Research Council
Funding Amount
$1,006,750.00
Summary
Atrial fibrillation (AF) is a heart rhythm problem that is 3 to 5 times more common in male athletes than the general male population - the reasons for this excess are not known. We hypothesize that the cardiac enlargement that is caused by high intensity exercise training increases the risk of AF. We will assess heart structure and function in 420 athletes across the age spectrum and assess the degree to which sports-induced changes are permanent and whether this represents an AF risk.
Exercise As Medicine For Heart Failure: A Novel Intervention To Improve Outcomes
Funder
National Health and Medical Research Council
Funding Amount
$665,585.00
Summary
Heart failure (HF) is a common, debilitating and expensive disease; prognosis remains poorer than for the most cancers. 30,000 Australians are diagnosed every year and 300,000 live with the HF, at an annual cost of ~$1Billion. Exercise training is effective therapy in HF, because it reverses many of the problems that contribute to the reduced lifespan and impaired quality of life of patients with HF. We will test an exciting new type of exercise that promising greater benefit, at lower risk.
Randomised Control Trial Of Exercise For The Management Of Cannabis Withdrawal In Adult Humans
Funder
National Health and Medical Research Council
Funding Amount
$542,036.00
Summary
This project will evaluate a novel approach to cannabis detoxification. It is hypothesized that undertaking an exercise intervention will reduce cannabis withdrawal symptoms by stimulating the release of cannabis-like compounds produced by the body and/or through promoting the release of THC (the main psychoactive component of cannabis) from fat stores. The potential public health, research and clinical implications are considerable, particularly given the high accessibility of the intervention.
A COMMUNITY BASED STRENGTH TRAINING PROGRAM TO IMPROVE WORK TASK PERFORMANCE IN YOUNG ADULTS WITH DOWN SYNDROME
Funder
National Health and Medical Research Council
Funding Amount
$180,649.00
Summary
This study will compare the outcomes of a 10 week twice a week community-based weight training program for young adults with Down syndrome with an art program. It will establish if a student-led exercise program can improve their performance of work tasks and their activity levels. Should the program prove beneficial, we aim to achieve the long-term outcome of exercise being implemented as a sustainable, inclusive recreation option for this group.
Long-term Physical Exercise Improves Cognitive Performance Through Neuroimmune Modulation
Funder
National Health and Medical Research Council
Funding Amount
$493,586.00
Summary
This research investigates for how long exercise needs to carried out in order to be beneficial for cognitive function. We choose an animal model which simulates chronic brain inflammation as seen during aging processes of humans and during many inflammatory diseases affecting brain function. This research will unravel the long-term immunomodulatory and protective effects of exercise on brain function as well as the short-term anti-inflammatory effects on brain function.
Epigenetic Impacts Of Paternal Experience On Offspring Anxiety And Cognition: Molecular Mediators And Therapeutic Targets
Funder
National Health and Medical Research Council
Funding Amount
$681,162.00
Summary
Stress and physical activity are two of the major lifestyle factors impacting on human health, including brain disorders. We have recently discovered that stress and exercise in male mice can impact the phenotype of offspring. We will study molecules in the sperm of these fathers, and in the brains of offspring to understand the mechanisms involved. There is evidence that lifestyle factors in men prior to conception impact on their children and this research has major public health implications.
Supplemental Oxygen In Pulmonary Rehabilitation Trial (SuppORT)
Funder
National Health and Medical Research Council
Funding Amount
$693,838.00
Summary
Approximately 50% of people with chronic obstructive pulmonary disease (COPD) who are referred to pulmonary rehabilitation have a reduction in oxygen during exercise. It is unknown whether providing oxygen during exercise training is beneficial in improving exercise capacity and quality of life in these people with COPD. This national multi-centre research will provide evidence to develop guidelines for the use of oxygen during exercise training in COPD.
AVERT-DOSE (Determining Optimal Early Rehabilitation After StrokE): A Multi-arm Covariate-adjusted, Response-adaptive Randomised Controlled Trial
Funder
National Health and Medical Research Council
Funding Amount
$4,359,564.00
Summary
AVERT-DOSE is an international, investigator-led clinical trial, developed in Australia but recruiting >2500 patients from 6 countries around the world. In this trial we will establish the optimal model of early mobility rehabilitation for people with acute stroke. The protocols we develop will be suitable for adoption in clinical practice in developed and developing countries and help reduce the unacceptably high personal and community burden of stroke-related disability world wide.