Nicotine abuse is the single greatest preventable risk factor for physical illness and death in Australians. Our understanding of the neural and cognitive mechanisms that underlie the transition from use to dependence is yet to be understood. The current proposal investigates the neural mechanisms underlying cognitive control, critical to self-control over the impulse for drug rewards, in non-dependent and dependent nicotine users.
The Role Of The Orbitofrontal Cortex In Disorders Of Response Inhibition
Funder
National Health and Medical Research Council
Funding Amount
$515,488.00
Summary
We will investigate the role of the orbitofrontal cortex (OFC) in decision-making, particularly the effect of hyperactivity in the medial vs. ventrolateral orbitofrontal cortex on decision-making. Hyperactivity in these structures has been linked to obsessive compulsive disorder and, in line with the distinct functions of the different regions of OFC, we develop and test a novel hypothesis as to the psychological and neural bases of the obsessions and compulsions distinctive to that disorder.
Characterising Quality Of Life And Its Determinants For Children With Intellectual Disability And Their Families
Funder
National Health and Medical Research Council
Funding Amount
$520,874.00
Summary
Approximately 2% of children are born with intellectual disability. They and their families often experience poor health and wellbeing. We will develop a measure of quality of life for affected children and then we will investigate how different factors affect both child and family quality of life. Our new measure will provide capacity to determine what treatments could improve the lives of affected children and their families.
Executive Dysfunction And Brain Development In Very Preterm 13-year-olds - A Longitudinal MRI Study.
Funder
National Health and Medical Research Council
Funding Amount
$738,656.00
Summary
An area of concern for very preterm children is executive function (i.e. skills used for problem solving), which is related to educational problems, behavioural issues and social difficulties. In very preterm children this study will 1) determine if executive function problems remain stable, worsen, or improve with age; 2) look for markers for these problems from infant brain scans; and 3) examine how executive function difficulties are related to brain re-organisation.
Do People With Severe Traumatic Brain Injury Benefit From Making Errors? A Clinical Trial Of The Efficacy Of Error-based Learning And Errorless Learning Training
Funder
National Health and Medical Research Council
Funding Amount
$579,142.00
Summary
People with severe traumatic brain injury (TBI) have trouble recognising changes in their abilities and often fail to notice mistakes on daily tasks. Although people can learn strategies, these are rarely used as needed in daily life. This study will determine whether people with severe TBI become more self-aware and able to transfer what they learn when they are made aware of their errors, as compared to when other people prevent them from making errors. The findings will have major implication ....People with severe traumatic brain injury (TBI) have trouble recognising changes in their abilities and often fail to notice mistakes on daily tasks. Although people can learn strategies, these are rarely used as needed in daily life. This study will determine whether people with severe TBI become more self-aware and able to transfer what they learn when they are made aware of their errors, as compared to when other people prevent them from making errors. The findings will have major implications for rehabilitation of neurological disorders.Read moreRead less
The Strong Families Trial: Randomised Controlled Trial Of A Family Strengthening Program To Prevent Unhealthy Weight Gain Among 5- To 11-year Old Children From At Risk Families
Funder
National Health and Medical Research Council
Funding Amount
$1,338,625.00
Summary
The study will test the effectiveness of an integrated package of parenting and lifestyle interventions for parents or carers from socially disadvantaged areas in reducing the risk of obesity among their 5-11 year-old children. It will provide scientific evidence of the additive effectiveness of a mixed parenting program when combined with a standard lifestyle intervention to prevent unhealthy weight gain and improving the family environment among mostly migrant populations
The ability of humans to detect and be aware of errors in behaviour is a fundamental aspect of human cognition. As the saying goes: "To Err Is Human". This project seeks to understand how individual differences in our genetic makeup contribute to our ability to detect and be aware of errors in our behaviour. Understanding the biological systems underpinning error monitoring may assist in the treatment of many psychiatric disorders which are marked by poor awareness of behaviour.
The Alert Program: An Evidence Based Treatment Program For Aboriginal Children Living With FASD (Fetal Alcohol Spectrum Disorder)
Funder
National Health and Medical Research Council
Funding Amount
$1,196,940.00
Summary
This study will research the effectiveness of the Alert Program to improve self-regulation and executive functioning skills in primary school aged children in the Fitzroy Valley, a vast area located within the Kimberley region of Western Australia. The project also aims to document a sustainable and culturally appropriate method of implementing a theraputic intervention that supports the improvement of skills in children living with fetal alcohol spectrum disorders within these communities.
Preventing Early Internalising Problems In The Preschool Setting: Randomised Controlled Trial
Funder
National Health and Medical Research Council
Funding Amount
$893,870.00
Summary
Internalising mental health problems reflect inner emotional distress and encompass all symptoms of anxiety and depression. Affecting 1 in 7 Australian school-age children, many internalising problems persist into adulthood, impacting on personal wellbeing, family relations and workforce capabilities. This randomised prevention trial in the preschool-setting, screens for children at-risk and tests if a parenting program can reduce internalising problems across the population by school-entry.