Rhinovirus Protease Subcellular Trafficking And Host Cell Targets; Relevance To Asthma Exacerbation And Vaccine Approaches
Funder
National Health and Medical Research Council
Funding Amount
$582,072.00
Summary
Rhinovirus (RV) infections are the major cause of virus induced asthma attacks, causing significant morbidity and mortality. Asthma & asthma exacerbations are increasing worldwide with new strategies urgently needed to reduce RV-associated disease. We aim to build on our substantive new data, using cutting edge technology to identify new targets for novel asthma therapies.
How The Immune Response Can Affect Influenza Virus And Asthma
Funder
National Health and Medical Research Council
Funding Amount
$333,964.00
Summary
A strong immune response is essential for protection against viral infections. However, in some circumstances a strong immune response against viruses can actually further aggravate disease. In addition, an anti-viral immune response can trigger asthma attacks in allergic individuals. This research thus seeks to understand and therefore mitigate the potentially detrimental role of inflammation in influenza virus infections and asthma.