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Phosphoproteomics: Metabolic And Exercise Signalling Markers For Sedentary And Trained Individuals
Funder
National Health and Medical Research Council
Funding Amount
$1,222,500.00
Summary
It is widely recognized that diet and exercise have a major influence on the health and fitness. Sedentary lifestyles predispose people to obesity and the early development of age onset diseases. In the past decade we have gained considerable insight into the regulatory links between exercise and metabolism particularly involving the AMPK signalling pathway. This project is concerned with the phosphoproteome of trained and untrained skeletal muscle, fat and erythrocytes as a marker of fitness.
Early Influences Of Obesity And Fat Patterning In Children:critical Periods, Environmental Determinants, And Socio-cultu
Funder
National Health and Medical Research Council
Funding Amount
$1,152,711.00
Summary
Childhood obesity is an escalating public health problem both internationally and within Australia. Rates of childhood obesity in Australia are at one of the highest amongst developed nations. 25% of Australian children are currently overweight or obese. Obesity is a strong risk factor for chronic disease. In children, obesity is of concern because it is highly likely to persist and, during childhood, contributes to serious physical and mental health problems. A quarter of Australian children ar ....Childhood obesity is an escalating public health problem both internationally and within Australia. Rates of childhood obesity in Australia are at one of the highest amongst developed nations. 25% of Australian children are currently overweight or obese. Obesity is a strong risk factor for chronic disease. In children, obesity is of concern because it is highly likely to persist and, during childhood, contributes to serious physical and mental health problems. A quarter of Australian children are now carrying excess body fat. Because of these factors, prevention of obesity is paramount because success of current treatment options is limited and does not last. Especially harmful forms of fatness may originate in early life - the tendency to store fat in the abdominal region and the tendency to accrete fat rather than muscle (at any body size). For this reason, the early life determinants of obesity deserve special attention, even in the presence of society-wide factors conducive to obesity. Professor Moore and a group of researchers from the University of Adelaide will test the proposition that pre-birth and infancy is a ‘critical period’ for the development of obesity. The group aims to investigate whether there is a distinct period in early life for acquiring the predisposition to harmful forms of fatness. The project also aims to identify practical opportunities for prevention, focusing on mothers and their infants.Read moreRead less
Gene Based Treatment Strategies For Diabetic Retinopathy
Funder
National Health and Medical Research Council
Funding Amount
$2,630,000.00
Summary
Diabetic retinopathy is the leading cause of blindness in the working population of developed countries and it is an increasing problem in the developing world. Present therapy involves extensive laser destruction of the light-detecting part of he retina. In addition, it is not only effective when administered at an appropriate stage in the disease process. Consequently, there is an urgent need for the development of better, prophylactic, easily administrable and cheaper therapies. This project ....Diabetic retinopathy is the leading cause of blindness in the working population of developed countries and it is an increasing problem in the developing world. Present therapy involves extensive laser destruction of the light-detecting part of he retina. In addition, it is not only effective when administered at an appropriate stage in the disease process. Consequently, there is an urgent need for the development of better, prophylactic, easily administrable and cheaper therapies. This project aims to develop a potentially permanent solution to alleviate diabetes-related blindness in the world. The project combines several very recent scientific advances into one strategy to combat diabetic retinopathy at a molecular level. Vision is our most important sensory organ that cannot be replaced. Thus, human trials can only be conducted following extensive animal safety and efficacy trials. To date the development of new therapies has been seriously hampered by the lack of appropriate, easy to reproduce animal models for different stages of diabetic retinopathy. In addition, it aims to identify new therapeutic agents from molecules that are naturally produced by the retina while fighting the disease. Finally, tested and evaluated in the animal models. The most successful therapeutic candidates will then be further developed for human trials.If successful, our approach will potentially have a major impact on the treatment of diabetic retinopathy and possibly on all diabetic vascular diseases. A single injection might only be necessary to prevent the development of diabetic retinopathy, which would represent a significant weapon in the management of patients. In addition, successful application of secretion gene therapy in the eye might open up the possibility to introduce the same concept for the treatment of larger organs undergoing microvascular changes as a result of diabetes.Read moreRead less
RCT Of Omega-3 Fatty Acids As Treatment Of Subthreshold Symptoms In Young People At Ultra-high Risk For
Funder
National Health and Medical Research Council
Funding Amount
$280,102.00
Summary
Omega-3 fats are a type of polyunsaturated fat which has long been thought to be beneficial for health. The body cannot make its own omega-3 fats - they must be taken in through the diet, or in supplement form. Large population-based studies have suggested that a diet rich in omega-3 fats can reduce the risk of cardiovascular disease, lower blood pressure, cut the risk of cancers such as prostate and skin. The fats have also been touted as a treatment for arthritis, asthma, and inflamed bowels. ....Omega-3 fats are a type of polyunsaturated fat which has long been thought to be beneficial for health. The body cannot make its own omega-3 fats - they must be taken in through the diet, or in supplement form. Large population-based studies have suggested that a diet rich in omega-3 fats can reduce the risk of cardiovascular disease, lower blood pressure, cut the risk of cancers such as prostate and skin. The fats have also been touted as a treatment for arthritis, asthma, and inflamed bowels. A lack of omega-3s during foetal development can hinder brain and eye development. Other work has suggested that a diet rich in omega-3 may help improve mental health. Studies revealed beneficial effects in a broad range of mental health problems including violent and aggressive behaviour in teenagers, major depression, bipolar affective disorder, borderline personality disorder, and schizophrenia. Evidence that omega-3 fatty acids may reduce symptoms in schizophrenia and other major psychiatric disorders make omega-3 fatty acids an optimal candidate for further evaluation of its therapeutic efficacy, in particular in young people in early illness stages of psychosis where specific intervention is controversial due to potential risks and medication side-effects. The proposed 12-week intervention study aims to establish a new treatment strategy alternative to antipsychotic medication in the young people with subthreshold symptoms at high risk for psychosis. Omega-3 fatty acids have no clinically relevant side effects which often accompany therapy with antipsychotics (such as diabetes and weight gain). A widely available, easy applicable, biological treatment without clinically relevant side effects could help to improve compliance and outcome in psychosis. Schizophrenia is often prolonged and results in a considerable economic burden. Early treatment has the potential to offset future costs to both mental health providers and the recipients of these services.Read moreRead less