Evolution, structure and function of key components in a molecular machine. The project will provide the basis for training of students and personnel in the previously recognized priority "Genomes-Phenomes", still the central theme of modern biology. In particular,
collaborations established with the Los Alamos National Laboratory in New Mexico will transfer to Australia expertise in the cutting edge discipline of small angle scattering for analysis of biologically important molecules. Such tr ....Evolution, structure and function of key components in a molecular machine. The project will provide the basis for training of students and personnel in the previously recognized priority "Genomes-Phenomes", still the central theme of modern biology. In particular,
collaborations established with the Los Alamos National Laboratory in New Mexico will transfer to Australia expertise in the cutting edge discipline of small angle scattering for analysis of biologically important molecules. Such training is essential for developing a future pool of skilled Australian scientists to staff and utilise the major national infrastructure developments represented by the Replacement Research Reactor and Australian Synchrotron, as outlined in the National Research Priority "Frontier Technologies".Read moreRead less
Investigating the subunit interactions of a molecular protein import machine. The project will provide fundamental knowledge of how sophisticated natural molecular machines interact with their substrates in plants and animals. It will also provide the basis for training of students and personnel in a range of structural biology technologies including several that are not commonly used by biologists, but make use of two major facilities that have been invested in by our government, namely the Aus ....Investigating the subunit interactions of a molecular protein import machine. The project will provide fundamental knowledge of how sophisticated natural molecular machines interact with their substrates in plants and animals. It will also provide the basis for training of students and personnel in a range of structural biology technologies including several that are not commonly used by biologists, but make use of two major facilities that have been invested in by our government, namely the Australian Synchrotron and the OPAL Research Reactor.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0237922
Funder
Australian Research Council
Funding Amount
$500,000.00
Summary
High Resolution Cryogenic Field Emission Environmental Scanning Electron Microscope Facility. A high resolution variable pressure scanning electron microscope will replace aging, heavily utilised facilities. It will be accessed by existing large and diverse user groups in a mature and internationally-recognised Centre. The novel combination of a cryogenic stage and the electrostatic beam blanking modification will support continuance of the local, world-leading research and application of new ....High Resolution Cryogenic Field Emission Environmental Scanning Electron Microscope Facility. A high resolution variable pressure scanning electron microscope will replace aging, heavily utilised facilities. It will be accessed by existing large and diverse user groups in a mature and internationally-recognised Centre. The novel combination of a cryogenic stage and the electrostatic beam blanking modification will support continuance of the local, world-leading research and application of new imaging techniques, particularly in the materials and mineral sciences. Both new nanotechnology and existing globally-significant industries will utilise the unique aspects of this instrument for product refinement and maintenance of commercial leadership, in partnership with local Universities and Government agencies.Read moreRead less
Enhanced biocatalysis in organic solvents for pharmaceutical biotransformation. Enzymes such as hydrolases play an important role in biotechnology because of their extreme versatility with respect to substrate specificity and stereoselectivity. The use of lipases as catalysts for optical isomer-specific organic reactions is often limited by unacceptably low enantioselectivities. We will investigate recombinant enzymes cloned from thermophilic lipolytic bacteria for synthetic reactions in orga ....Enhanced biocatalysis in organic solvents for pharmaceutical biotransformation. Enzymes such as hydrolases play an important role in biotechnology because of their extreme versatility with respect to substrate specificity and stereoselectivity. The use of lipases as catalysts for optical isomer-specific organic reactions is often limited by unacceptably low enantioselectivities. We will investigate recombinant enzymes cloned from thermophilic lipolytic bacteria for synthetic reactions in organic solvents, especially chiral resolution of mixtures in the production of pharmaceutical intermediates. Genetic improvement of lipase enantiospecificity and regioselectivity will be achieved using in vitro evolution by recombination and screening. The outcome will be cost-effective production superior biocatalysts with specifically enhanced regiospecific, enantioselective and hydrolytic characteristics.
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The chemical, biochemical, genetic and ecological basis of pollinator-driven speciation in Australian sexually deceptive orchids. The Australian biota offers unique opportunities for illuminating ecological and evolutionary processes of worldwide importance. Focussing on Australian sexually deceptive orchids, this study offers a model system for studies of plant speciation that has already captured the interest of the public, educators and scientists around the world. The project will produce mu ....The chemical, biochemical, genetic and ecological basis of pollinator-driven speciation in Australian sexually deceptive orchids. The Australian biota offers unique opportunities for illuminating ecological and evolutionary processes of worldwide importance. Focussing on Australian sexually deceptive orchids, this study offers a model system for studies of plant speciation that has already captured the interest of the public, educators and scientists around the world. The project will produce multiple graduate students with high quality, cross-disciplinary training. Expertise and tools developed will contribute directly to the conservation of endangered Australian orchids. Thus the knowledge obtained from this research will have immediate practical benefits for the sustainable use of Australia's biodiversity.Read moreRead less
Cellular and network basis of information processing in the mammalian visual system. The project aims to discover the strategies by which cells in the brain interact with each other to code the sensory input efficiently. It is expected that simultaneous recording of the activity of many neurones from the visual cortex of anaesthetised cats during visual stimulation will reveal how the biophysics of synaptic integration combined with excitatory and inhibitory inputs from different sources sculpt ....Cellular and network basis of information processing in the mammalian visual system. The project aims to discover the strategies by which cells in the brain interact with each other to code the sensory input efficiently. It is expected that simultaneous recording of the activity of many neurones from the visual cortex of anaesthetised cats during visual stimulation will reveal how the biophysics of synaptic integration combined with excitatory and inhibitory inputs from different sources sculpts the output of individual neurones. The experiments will be extended to the study of possible interactions between different areas of the brain and the study of mechanisms by which the cortical network and higher cognitive factors such as attention and memory might influence the coding of sensory information in awake animals.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0454008
Funder
Australian Research Council
Funding Amount
$340,962.00
Summary
Multi-function high resolution-analytical scanning electron microscope facility. The aim of this proposal is to establish a high resolution electron microscope facility as part of a comprehensive materials characterisation infrastructure required to support Swinburne's expanding activities in nanotechnology. A high resolution SEM in conjunction with an upgrade of the current SEM will provide advanced instrumentation for nanoscale imaging, analysis and manipulation of materials. The proposed faci ....Multi-function high resolution-analytical scanning electron microscope facility. The aim of this proposal is to establish a high resolution electron microscope facility as part of a comprehensive materials characterisation infrastructure required to support Swinburne's expanding activities in nanotechnology. A high resolution SEM in conjunction with an upgrade of the current SEM will provide advanced instrumentation for nanoscale imaging, analysis and manipulation of materials. The proposed facility will create new opportunities for collaborative programs with local and overseas researcher and will facilitate rapid progress in research programs across the entire University in particular those related to two ARC Centres of Excellence in which the University is a core partner.Read moreRead less
Development of Novel Detergents for Green Solvent Systems and Their Self-Assembly into Nanostructures. Successful outcomes from this collaborative project will lead to the development of new commercially viable green solvent systems for the chemical industry, e.g. dry cleaning. This has the potential to impact the community on the economic and environmental level, by significantly reducing the costs of current green solvent systems, resulting in greater likelihood of conventional toxic solvent ....Development of Novel Detergents for Green Solvent Systems and Their Self-Assembly into Nanostructures. Successful outcomes from this collaborative project will lead to the development of new commercially viable green solvent systems for the chemical industry, e.g. dry cleaning. This has the potential to impact the community on the economic and environmental level, by significantly reducing the costs of current green solvent systems, resulting in greater likelihood of conventional toxic solvents being replaced. The project will also expand the training of junior and early career scientists by allowing them to work in overseas laboratories.Read moreRead less
Modelling of multiscale systems in engineering and science supports large-scale equation-free simulations and analysis. A persistent feature of complex systems in engineering and science is the emergence of macroscopic, coarse grained, coherent behaviour from the interactions of microscopic agents (molecules, cells) and with their environment. In current modeling, ranging from ecology to materials science, the underlying microscopic mechanisms are known, but the closures to translate microscale ....Modelling of multiscale systems in engineering and science supports large-scale equation-free simulations and analysis. A persistent feature of complex systems in engineering and science is the emergence of macroscopic, coarse grained, coherent behaviour from the interactions of microscopic agents (molecules, cells) and with their environment. In current modeling, ranging from ecology to materials science, the underlying microscopic mechanisms are known, but the closures to translate microscale knowledge to a system level macroscopic description are rarely available in closed form. Our novel, equation free, computational methodologies will circumvent this stumbling block, and promises to radically change the modeling, exploration and understanding of complex system behavior. We continue to develop this powerful computational methodology. Read moreRead less
New Polymers for Cellulose-based Bioplastics. We will design new cellulose derivatives by combining carefully engineered synthetic polymers to cellulose. We will explore the fundamental science underpinning the manufacture of these bioplastics, and apply the concept to the design of two new materials, with (super)hydrophobic and antibacterial properties. These materials have the potential to replace synthetic plastics, which comprise one of the major outputs of the chemical industry worldwide. P ....New Polymers for Cellulose-based Bioplastics. We will design new cellulose derivatives by combining carefully engineered synthetic polymers to cellulose. We will explore the fundamental science underpinning the manufacture of these bioplastics, and apply the concept to the design of two new materials, with (super)hydrophobic and antibacterial properties. These materials have the potential to replace synthetic plastics, which comprise one of the major outputs of the chemical industry worldwide. Plastic is present everywhere in human life, but its manufacture and disposal have a strong negative impact on the environment; the new materials manufactured in this project are viable alternatives to plastics, and are sustainable from a production and disposal point of view.Read moreRead less