Evolution of the dermomyotome in vertebrates. The project seeks to understand how different muscle populations within the embryo form and have evolved within the vertebrate phylogeny. All amniote muscles, except that of the head, derive from a transient embryonic structure termed the dermomyotome. The formation of muscle from the dermomyotome of amniotes uses a highly conserved mechanism that is distinct from that deployed by bony fish and amphibians. How the dermomyotome evolved to generate th ....Evolution of the dermomyotome in vertebrates. The project seeks to understand how different muscle populations within the embryo form and have evolved within the vertebrate phylogeny. All amniote muscles, except that of the head, derive from a transient embryonic structure termed the dermomyotome. The formation of muscle from the dermomyotome of amniotes uses a highly conserved mechanism that is distinct from that deployed by bony fish and amphibians. How the dermomyotome evolved to generate the distinct types of locomotor systems we see deployed throughout the vertebrate phylogeny remains unresolved. This project aims to contribute to an understanding of how different locomotor strategies deployed at important evolutionary transitions were generated.Read moreRead less
Fleshing out the fossil record: using organically preserved soft tissues and bone to explore the evolution of unique vertebrate characters. This study integrates developmental, molecular and morphological data in both fossil and living species to provide insights into the evolutionary mechanisms which formed the musculo/skeletal system. Uncovering these evolutionary pathways has the potential to describe mechanisms common to all vertebrate and informs us about our own evolution.
Identifying The Pathological Mechanism Of PCDH19-Girls Clustering Epilepsy
Funder
National Health and Medical Research Council
Funding Amount
$523,988.00
Summary
Changes in the PCDH19 gene are a relatively common cause of epilepsy. To better understand the basis of this disorder, we have developed unique mouse models that mimic the genetic changes and symptoms of this condition. We will perform careful analysis of brain development in these models to determine the primary cause of this condition. These experiments will create greater understanding of how changes in PCDH19 cause epilepsy in girls and facilitate the development of new treatments.
How do qualifications delivered by enterprises contribute to improved skill levels and other benefits for companies, workers and the nation? This project investigates the role of employer-based qualifications training in developing the skills and prospects of the Australian workforce and the competitive capabilities of companies. It focuses on enterprises that are accredited to deliver qualifications to their own workers, providing data to improve and expand this form of training.
ARC Centre of Excellence for Children and Families over the Life Course. New solutions are needed to underpin the Australian social ideal of a fair go, and to drive future global economic productivity. The Australian Productivity Commission identifies deep and persistent disadvantage as a significant problem in Australia given the failure of growing national prosperity over the past two decades to benefit underprivileged Australians. Social disadvantage is a global challenge. This Centre will ad ....ARC Centre of Excellence for Children and Families over the Life Course. New solutions are needed to underpin the Australian social ideal of a fair go, and to drive future global economic productivity. The Australian Productivity Commission identifies deep and persistent disadvantage as a significant problem in Australia given the failure of growing national prosperity over the past two decades to benefit underprivileged Australians. Social disadvantage is a global challenge. This Centre will advance basic, applied and translational research to reduce intergenerational and long-term disadvantage. Through the maturation of longitudinal datasets and advanced data integration we can follow the journeys of Australian families over generations and across the life course. This data will provide evidence for new policies and make a real difference to the lives of children and families.Read moreRead less
Genome-wide Association Study (GWAS) For Juvenile-onset Myopia And Its Component Measures To Identify Molecular Pathways To Prevent Myopia
Funder
National Health and Medical Research Council
Funding Amount
$495,364.00
Summary
We will examine 2,000 young adults from the Western Australian Raine Cohort at the Lions Eye Institute / University of Western Australia. Ocular data will be collected relating to myopia (short-sightedness) and will be combined with extensive previous childhood and genetic research data collected on the Cohort, to investigate the genetic and environmental factors predisposing to myopia. This will assist in understanding the factors leading to myopia.
Discovery Early Career Researcher Award - Grant ID: DE160100197
Funder
Australian Research Council
Funding Amount
$395,000.00
Summary
National schooling reform and the reshaping of Australian federalism. The aim of this project is to examine how national schooling reforms in curriculum, pedagogy and assessment are reshaping the role of Australian state governments in education policy. It will focus on the impact of reforms on state education departments, and through policy analysis, interviews and case studies in three Australian states, the project intends to generate theoretical insights about the changing nature of Australi ....National schooling reform and the reshaping of Australian federalism. The aim of this project is to examine how national schooling reforms in curriculum, pedagogy and assessment are reshaping the role of Australian state governments in education policy. It will focus on the impact of reforms on state education departments, and through policy analysis, interviews and case studies in three Australian states, the project intends to generate theoretical insights about the changing nature of Australian schooling and federalism.Read moreRead less
Redefining sediment transport predictions in benthic ecosystems. This project aims to understand and predict the mobilisation of sediment, and the rates and modes of sediment transport. Sediment dynamics control the health and productivity of some of the world’s most valuable marine ecosystems, including seagrass meadows and coral reefs. However, the theory and predictive models needed to quantitatively understand sediment transport over the large bottom roughness in these ecosystems has proven ....Redefining sediment transport predictions in benthic ecosystems. This project aims to understand and predict the mobilisation of sediment, and the rates and modes of sediment transport. Sediment dynamics control the health and productivity of some of the world’s most valuable marine ecosystems, including seagrass meadows and coral reefs. However, the theory and predictive models needed to quantitatively understand sediment transport over the large bottom roughness in these ecosystems has proven elusive. This project will integrate comprehensive laboratory and field programmes to develop predictive models of these sediment dynamics, which should help better understand, manage and protect these critical ecosystems and their services.Read moreRead less
Sex determination in dragons: Genetics, epigenetics and environment. This project aims to discover the master sex-determining gene in a reptile, how that gene is differentially regulated in males and females and by temperature, and to identify evolutionary drivers of transitions between genetic and environmental sex determination. In many reptiles, like mammals, chromosomes determine sex. In others, the temperature at which their eggs are incubated determines sex. This project will study how tem ....Sex determination in dragons: Genetics, epigenetics and environment. This project aims to discover the master sex-determining gene in a reptile, how that gene is differentially regulated in males and females and by temperature, and to identify evolutionary drivers of transitions between genetic and environmental sex determination. In many reptiles, like mammals, chromosomes determine sex. In others, the temperature at which their eggs are incubated determines sex. This project will study how temperature reverses chromosomal sex determination in dragon lizards. This could show how climatic extremes affect the biology of climate sensitive reptiles, and understand their vulnerability to climate change.Read moreRead less
From child learner to adult musician: Factors leading to success and ongoing participation in music. Building on recommendations from the Commonwealth Government's National Review of School Music Education (2005), this project seeks to clarify the factors that facilitate engagement in music. Building on data collected 10 years ago, the proposed follow up study will enable us to trace how Australian education in the form of school instrumental programs influence musical development, interest and ....From child learner to adult musician: Factors leading to success and ongoing participation in music. Building on recommendations from the Commonwealth Government's National Review of School Music Education (2005), this project seeks to clarify the factors that facilitate engagement in music. Building on data collected 10 years ago, the proposed follow up study will enable us to trace how Australian education in the form of school instrumental programs influence musical development, interest and attainment from childhood through to early adulthood. With this information, the study will enable us to identify how Australian education can be developed to facilitate the life-long enjoyment that artistic appreciation and participation can offer as a result of school music. Read moreRead less