The Epigenetics of Sex in the Dragon. Genetic codes do not directly translate to phenotypes -- environment acts through epigenetics to modify development. We use advanced molecular techniques to examine how epigenetics responds to temperature to reverse sex in our novel animal model, the dragon lizard. How does the cell sense temperature? Once the extrinsic signal is captured, how does it influence chromatin modification to release or suppress key genes in the sex differentiation pathway? Which ....The Epigenetics of Sex in the Dragon. Genetic codes do not directly translate to phenotypes -- environment acts through epigenetics to modify development. We use advanced molecular techniques to examine how epigenetics responds to temperature to reverse sex in our novel animal model, the dragon lizard. How does the cell sense temperature? Once the extrinsic signal is captured, how does it influence chromatin modification to release or suppress key genes in the sex differentiation pathway? Which sex genes are targets? Epigenetic enzymes are astonishingly conserved, providing exciting opportunities to draw from human systems to unravel novel signatures of temperature-induced sex switching in reptiles. This project will advance knowledge of developmental programming generally.Read moreRead less
Global climate change and coastal landscape evolution in southern Australia. This project aims to reconstruct environmental changes that occurred in southern Australia during a geologically recent time interval termed the Early-Middle Pleistocene Transition (1.2 million to 700 thousand years ago) and an interglacial period some 400,000 years ago. Using innovative geochronological, geochemical and modelling techniques, the environmental changes that shaped modern Australian coastal landscapes, in ....Global climate change and coastal landscape evolution in southern Australia. This project aims to reconstruct environmental changes that occurred in southern Australia during a geologically recent time interval termed the Early-Middle Pleistocene Transition (1.2 million to 700 thousand years ago) and an interglacial period some 400,000 years ago. Using innovative geochronological, geochemical and modelling techniques, the environmental changes that shaped modern Australian coastal landscapes, including the intensification of aridity and their timing will be examined. The project will yield new knowledge about the sensitivity of landscapes to current and ongoing environmental changes and derive explanatory models of the rates and characteristics of landscape response to assist future coastal environmental management.Read moreRead less
Earth's Dynamic Topography Through Space and Time. A key component of Earth’s topography remains enigmatic. This so-called dynamic topography is transient, varying in response to convection within Earth’s mantle. This project aims to use a data-driven computational approach to: (i) reconstruct the evolution of dynamic topography over the recent geological history of our planet (Cenozoic Era, 0-66 million years ago); and (ii) uncover the mechanisms controlling its spatial and temporal evolution. ....Earth's Dynamic Topography Through Space and Time. A key component of Earth’s topography remains enigmatic. This so-called dynamic topography is transient, varying in response to convection within Earth’s mantle. This project aims to use a data-driven computational approach to: (i) reconstruct the evolution of dynamic topography over the recent geological history of our planet (Cenozoic Era, 0-66 million years ago); and (ii) uncover the mechanisms controlling its spatial and temporal evolution. This transformational new understanding will connect the evolution of our planet's surface environments to its deep interior, revealing the impact of dynamic topography on sea level change, flooding, river networks, groundwater systems, habitat development and the distribution of economic resources. Read moreRead less
Evolution and mechanisms of interactions in biofilm communities. This project aims to study the long-term experimental evolution of a mixed species bacterial biofilm community. This project expects to gain understanding of the genetic and physiological basis of community evolution. Expected outcomes of this project will be an understanding of how synthetic communities evolve. This will significantly benefit the use of synthetic communities relevant to fields such as antibiotic design, biotechnol ....Evolution and mechanisms of interactions in biofilm communities. This project aims to study the long-term experimental evolution of a mixed species bacterial biofilm community. This project expects to gain understanding of the genetic and physiological basis of community evolution. Expected outcomes of this project will be an understanding of how synthetic communities evolve. This will significantly benefit the use of synthetic communities relevant to fields such as antibiotic design, biotechnology, bioremediation, and synthetic biology where evolution can be inhibited or exploited, respectively.Read moreRead less
Women, politics and democracy: political labour in India and Indonesia . This project aims to advance understandings of Asia's two largest democracies through an examination of the pathways and dead-ends to political power for women in India and Indonesia. Research of women's everyday political labour will examine their contributions to generating different forms of power, and their adverse incorporation into political structures. The comparative ethnographic approach will lead to the developme ....Women, politics and democracy: political labour in India and Indonesia . This project aims to advance understandings of Asia's two largest democracies through an examination of the pathways and dead-ends to political power for women in India and Indonesia. Research of women's everyday political labour will examine their contributions to generating different forms of power, and their adverse incorporation into political structures. The comparative ethnographic approach will lead to the development of analytical and conceptual tools to understand democracy across different socio-historical contexts. The project aims to produce policy and practice relevant knowledge to increase the meaningful participation of women in politics in India and Indonesia, with comparative lessons for other countries Read moreRead less
Preventing railway suicide: An open-systems perspective. Preventing railway suicide: An open-systems perspective. This project aims to develop an automated suicide risk detection system to reduce the incidence and impact of railway suicide, which has a devastating effect on victims’ families, station staff, train drivers, emergency workers, and bystanders. This project will use open-systems theory to develop two complementary information systems for more effective detection and reporting of suic ....Preventing railway suicide: An open-systems perspective. Preventing railway suicide: An open-systems perspective. This project aims to develop an automated suicide risk detection system to reduce the incidence and impact of railway suicide, which has a devastating effect on victims’ families, station staff, train drivers, emergency workers, and bystanders. This project will use open-systems theory to develop two complementary information systems for more effective detection and reporting of suicide risk; use these systems to investigate how different situational factors interact with different combinations of service interventions to influence suicide risk; and share the findings to reduce railway suicide in Australia and overseas.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE230100003
Funder
Australian Research Council
Funding Amount
$387,373.00
Summary
The evolution of venom and its role in shaping biodiversity. This project aims to study how venom, nature's most powerful weapon, evolves and shapes biodiversity. Using the iconic Australian and New Guinean venomous snakes as a model, this project expects to develop a novel approach to profile venom composition from museum specimens, test competing hypotheses on the evolution of venoms, and test for the association between the evolution of venoms and the evolution of diversity in species richnes ....The evolution of venom and its role in shaping biodiversity. This project aims to study how venom, nature's most powerful weapon, evolves and shapes biodiversity. Using the iconic Australian and New Guinean venomous snakes as a model, this project expects to develop a novel approach to profile venom composition from museum specimens, test competing hypotheses on the evolution of venoms, and test for the association between the evolution of venoms and the evolution of diversity in species richness and morphology. Expected outcomes include the largest venom database for any animal group and a better understanding of how venoms evolve and what role they play in earth’s biodiversity. The generated venom data has potential to be used in future studies to aid in the development of anti-venoms and drugs.Read moreRead less
Control of network systems with signed dynamical interconnections. New technologies such as online recommendations, smart grids, and cyber-physical systems are becoming backbone infrastructure. Such systems are operated as network systems with interconnected functioning units (agents) where cooperative and adversarial agent relations often coexist. This project aims to develop the theories and tools for designing and building dynamic networks with signed interactions that arise from a variety of ....Control of network systems with signed dynamical interconnections. New technologies such as online recommendations, smart grids, and cyber-physical systems are becoming backbone infrastructure. Such systems are operated as network systems with interconnected functioning units (agents) where cooperative and adversarial agent relations often coexist. This project aims to develop the theories and tools for designing and building dynamic networks with signed interactions that arise from a variety of applications where both cooperative and adversarial agent interactions coexist. By developing theories and algorithms for control and identification over such systems, this project will contribute directly to their safe and robust operation. The resulting theories will provide deeper understanding of network control systems and the resulting algorithms will enable the elimination of attackers and malicious users for online review systems and smart grids. This project will contribute to increased cybersecurity for all Australians.Read moreRead less
Observe, Reflect, Improve: a tool to enrich Children’s Learning (ORICL). This project aims to address long-standing concerns about the quality of education and care for children during their critical first two years. It will introduce a promising, future-focused digital tool, co-designed with practitioners and providers of early childhood services, to support infant-toddler educators’ planning and practice. Building on ground-breaking pilot work, we will undertake a national implementation and e ....Observe, Reflect, Improve: a tool to enrich Children’s Learning (ORICL). This project aims to address long-standing concerns about the quality of education and care for children during their critical first two years. It will introduce a promising, future-focused digital tool, co-designed with practitioners and providers of early childhood services, to support infant-toddler educators’ planning and practice. Building on ground-breaking pilot work, we will undertake a national implementation and evaluation of the Observe, Reflect and Improve Children’s Learning (ORICL) tool. Expected outcomes include: enhanced pedagogical practices; enriched learning experiences for children birth-two; effective communication with families; and improved resourcing for providers of early childhood education and care services. Read moreRead less
Control and learning for enhancing capabilities of quantum sensors. This project aims to develop new theories and algorithms to enhance capabilities in engineering quantum sensors from the perspective of systems and control. The project is significant because it is anticipated to advance key knowledge and provide systematic methods to enable achievement of high-precision sensing for wide applications, e.g., early disease detection, medical research, discovery of ore deposits and groundwater moni ....Control and learning for enhancing capabilities of quantum sensors. This project aims to develop new theories and algorithms to enhance capabilities in engineering quantum sensors from the perspective of systems and control. The project is significant because it is anticipated to advance key knowledge and provide systematic methods to enable achievement of high-precision sensing for wide applications, e.g., early disease detection, medical research, discovery of ore deposits and groundwater monitoring. The intended outcomes are fundamental theories, effective control and learning algorithms for achieving highly-sensitive sensors. These outcomes should make important contributions to and deliver new knowledge and skills for Australia's sensing industries, which could benefit Australia's economic growth.Read moreRead less