Evolutionary Response Of Dengue And Chikungunya Viruses To A Novel Biocontrol Method
Funder
National Health and Medical Research Council
Funding Amount
$421,681.00
Summary
Dengue and chikungunya are mosquito-transmitted viruses that present significant public health threats to Australia and the Asia-Pacific. This project will investigate whether dengue and chikungunya can adapt in response to a bacterium that limits replication of the viruses in the mosquito. The research will provide critical data to inform new mosquito control methods aimed at breaking the virus transmission cycle. More broadly, the research will allow us to understand how viruses adapt to strat ....Dengue and chikungunya are mosquito-transmitted viruses that present significant public health threats to Australia and the Asia-Pacific. This project will investigate whether dengue and chikungunya can adapt in response to a bacterium that limits replication of the viruses in the mosquito. The research will provide critical data to inform new mosquito control methods aimed at breaking the virus transmission cycle. More broadly, the research will allow us to understand how viruses adapt to strategies aimed at limiting their replication.Read moreRead less
Exploring Resistance Of Plasmodium Vivax To Antimalarial Drugs: A Retrospective And Prospective Study
Funder
National Health and Medical Research Council
Funding Amount
$439,230.00
Summary
Although previously considered a 'benign' form of the disease, vivax malaria is increasingly recognised as a cause of complications and even death. Unfortunately, the parasite is developing resistance to conventional drugs. Papua New Guinea was where resistance to chloroquine was first detected and other drugs are following suit. We plan to examine the parasite genes involved in this process, including before and after the introduction of a new strategy in PNG, artemisinin combination therapy.
Adaptation to life in the dark: genomic analyses of blind beetles. This project aims to utilise a unique Australian model system based on multiple, independently-evolved subterranean water beetles to explore the adaptive and regressive changes in the genome that occur when surface species colonise subterranean habitats. This project focuses on the evolution of Heat Shock protein (Hsp) genes that play critical roles in adaptation to environmental stress and the process of de-canalisation, the rel ....Adaptation to life in the dark: genomic analyses of blind beetles. This project aims to utilise a unique Australian model system based on multiple, independently-evolved subterranean water beetles to explore the adaptive and regressive changes in the genome that occur when surface species colonise subterranean habitats. This project focuses on the evolution of Heat Shock protein (Hsp) genes that play critical roles in adaptation to environmental stress and the process of de-canalisation, the release of cryptic genetic variation that can allow novel morphologies to evolve in new environments. The project expects to provide further understanding of how species may potentially adapt to environmental stresses in the future, including climate change.Read moreRead less
Is regressive evolution associated with loss of gene function in subterranean animals? This project aims to investigate a fundamental biological process: the evolutionary basis for how non-functional characters, such as eyes in subterranean animals, are lost. It will use a unique model system based on eyeless water beetles, and utilise novel new genomic tools to test whether loss of characters results from gene inactivation.
Refining the timescale of human evolution and dispersal using ancient DNA. Understanding the timescale of human evolution and migration is a key goal of genetic analysis. It provides the foundation for studying our evolutionary and demographic history, our relationships to other hominids and our impact on the natural world. This project aims to use ancient DNA data to improve estimates of our evolutionary timescale.
Characterising rates of molecular evolution across the Tree of Life. This project aims to characterise the variation in molecular evolutionary rates across the Tree of Life. Despite advances in genetic methods and genomic data, a critical gap remains in knowledge of evolutionary rates across species. The project will evaluate and refine methods for estimating rates, develop genomic data for molecular clocks, create an online database of rate estimates, and reconstruct ecological communities’ res ....Characterising rates of molecular evolution across the Tree of Life. This project aims to characterise the variation in molecular evolutionary rates across the Tree of Life. Despite advances in genetic methods and genomic data, a critical gap remains in knowledge of evolutionary rates across species. The project will evaluate and refine methods for estimating rates, develop genomic data for molecular clocks, create an online database of rate estimates, and reconstruct ecological communities’ responses to past environmental and climatic factors. The project’s database of evolutionary rates in different species is expected to increase understanding of evolutionary and demographic events across species, including the Australian biota, and improve conservation efforts.Read moreRead less
Recombination and the genomic landscape of speciation. This project aims to evaluate how genomes become different during the origin of species by utilising an innovative system where multiple replicates of the speciation process exist. This project expects to generate knowledge in the area of speciation genetics by exploring the effects of sex, migration and selection on the diversity of hundreds of genomes from an Australian wildflower. Expected outcomes of this project include a deeper underst ....Recombination and the genomic landscape of speciation. This project aims to evaluate how genomes become different during the origin of species by utilising an innovative system where multiple replicates of the speciation process exist. This project expects to generate knowledge in the area of speciation genetics by exploring the effects of sex, migration and selection on the diversity of hundreds of genomes from an Australian wildflower. Expected outcomes of this project include a deeper understanding of the maintenance of genetic diversity in natural populations, and development of a model organism for studying the genetics and ecology of speciation. This project should provide significant benefits including enhanced capacity in evolutionary genetics in Australia.Read moreRead less
How does developmental plasticity shape adaptation to environmental change? This project aims to address how animals adapt to environmental change by examining a process largely ignored in current studies: how the environment alters animal development. This project expects to generate new knowledge in the area of the genetics of adaptation using an innovative approach to determine how genetic variation, environmental conditions, and development interact to shape adaptation to changing environmen ....How does developmental plasticity shape adaptation to environmental change? This project aims to address how animals adapt to environmental change by examining a process largely ignored in current studies: how the environment alters animal development. This project expects to generate new knowledge in the area of the genetics of adaptation using an innovative approach to determine how genetic variation, environmental conditions, and development interact to shape adaptation to changing environments. Expected outcomes of this project include enhancing predictions of how species respond to climate change and building capacity for international collaborations. The intended impact of this project is to increase our understanding of how animals respond to environmental change by determining how multiple environmental cues act together to alter development, and how the genetic makeup of the individual affects these responses.Read moreRead less
Defining unconscious and artificial selection. In 1868 Charles Darwin proposed that the process of domestication can be divided into two independent selective processes we now call unconscious and artificial selection. In this project, we include the Australian dingo as a functional intermediate between the wild wolf and domestic dogs and test Darwin's hypothesis using modern molecular and statistical techniques. It is now widely accepted that the dingo was not domesticated by indigenous Austral ....Defining unconscious and artificial selection. In 1868 Charles Darwin proposed that the process of domestication can be divided into two independent selective processes we now call unconscious and artificial selection. In this project, we include the Australian dingo as a functional intermediate between the wild wolf and domestic dogs and test Darwin's hypothesis using modern molecular and statistical techniques. It is now widely accepted that the dingo was not domesticated by indigenous Australians and is therefore the ideal extant population for the project. The project is significant because it will be a critical test of Darwin's hypothesis. The outcome could be an improved understanding of the genomic basis for selection that can inform the process of domestication.Read moreRead less
The role of recombination in eucalypt evolution. Meiotic recombination is a key source of the genetic variation upon which evolution thrives. This project aims to exploit new genomic resources to provide the first detailed study of recombination in Australia’s iconic Eucalypts and clarify its evolutionary role. This project will study: variation in the rate of recombination along the 11 Eucalypt chromosomes, and determine genome features which are associated with ‘hotspots’ and ‘coldspots’ of re ....The role of recombination in eucalypt evolution. Meiotic recombination is a key source of the genetic variation upon which evolution thrives. This project aims to exploit new genomic resources to provide the first detailed study of recombination in Australia’s iconic Eucalypts and clarify its evolutionary role. This project will study: variation in the rate of recombination along the 11 Eucalypt chromosomes, and determine genome features which are associated with ‘hotspots’ and ‘coldspots’ of recombination; the patterns of variation in recombination rate between species, genotypes, sexes and chromosomes; and, whether the environment and population history affect recombination and thus evolvability of natural populations.Read moreRead less