The essence of being an animal: sponge allorecognition and the evolution of individuality. The human genome encodes the ability to recognise self from nonself at the cellular level. In medicine, this innate ability results in the rejection of transplanted (grafted) tissues from unrelated individuals. This project seeks to get to the evolutionary foundation of self-nonself recognition by studying this process in a simple and tractable model - a sponge from the Great Barrier Reef. Like humans, spo ....The essence of being an animal: sponge allorecognition and the evolution of individuality. The human genome encodes the ability to recognise self from nonself at the cellular level. In medicine, this innate ability results in the rejection of transplanted (grafted) tissues from unrelated individuals. This project seeks to get to the evolutionary foundation of self-nonself recognition by studying this process in a simple and tractable model - a sponge from the Great Barrier Reef. Like humans, sponges reject cells and tissues derived from another individual. By defining the genetic basis of self-recognition in sponges we reveal the antiquity of this system and the core features of histocompatibility and immunity. Such insights can inform a range of regenerative medical pursuits.Read moreRead less
The evolution of dim light vision in vertebrates. High sensitivity (rod-based) vision has been extremely important for the survival and adaptive radiation of many vertebrates, including humans over evolutionary time. This multidisciplinary project will reveal the evolutionary and physiological constraints on early photoreception and the difficulties in operating over an enormous range of lighting conditions. Not only will the findings be crucial for our understanding of basic mechanisms of dim l ....The evolution of dim light vision in vertebrates. High sensitivity (rod-based) vision has been extremely important for the survival and adaptive radiation of many vertebrates, including humans over evolutionary time. This multidisciplinary project will reveal the evolutionary and physiological constraints on early photoreception and the difficulties in operating over an enormous range of lighting conditions. Not only will the findings be crucial for our understanding of basic mechanisms of dim light vision, but also provide potential insights into the physiological bases of various rod dystrophies affecting humans and the improved design of more sensitive cameras and safe light environments for rearing animals in captivity e.g. for aquaculture.Read moreRead less
Evolution of the biofabrication of mineralized structures in animals. Shells and skeletons are produced by a wide range of animals. These highly-order crystalline structures are genetically-encoded and produce high-performance composite materials that exceed present capabilities in human engineering. This international collaboration will elucidate the molecular mechanisms controlling the fabrication of these architectures. This knowledge will contribute significantly to the development of materi ....Evolution of the biofabrication of mineralized structures in animals. Shells and skeletons are produced by a wide range of animals. These highly-order crystalline structures are genetically-encoded and produce high-performance composite materials that exceed present capabilities in human engineering. This international collaboration will elucidate the molecular mechanisms controlling the fabrication of these architectures. This knowledge will contribute significantly to the development of materials for advanced electronics and energy transducers, human bone therapeutics and marine-based products such as pearls and cements, through the identification of genes underlying biofabrication networks and the development of in vitro bioproduction systems.Read moreRead less
Regulation of saxitoxin production in bacteria and algae. In Australia, toxic algal blooms have had a devastating impact on marine and freshwater resources. In collaboration with a biotechnology company, this project will develop exciting new methods based on information regarding the genetics of the toxin, to monitor and potentially mitigate the effects of algal blooms on water supplies and aquaculture industries. We will use this method to determine the impact of light and salinity in regulati ....Regulation of saxitoxin production in bacteria and algae. In Australia, toxic algal blooms have had a devastating impact on marine and freshwater resources. In collaboration with a biotechnology company, this project will develop exciting new methods based on information regarding the genetics of the toxin, to monitor and potentially mitigate the effects of algal blooms on water supplies and aquaculture industries. We will use this method to determine the impact of light and salinity in regulating toxin production in cyanobacteria and algae.Read moreRead less
Predictive ichthyotoxicity, diagnostics and risk assessment of harmful algal blooms impacting on the Tasmanian salmonid aquaculture industry. We aim to define through a combination of laboratory culture exposure and live cage bioassay experiments the minimum cell concentrations of harmful microalgae (Karenia, Heterosigma, Noctiluca, Chaetoceros) that can cause salmonid mortalities or are a factor in compromising fish health or reducing fish farm productivity. The diagnostic pathology and fish be ....Predictive ichthyotoxicity, diagnostics and risk assessment of harmful algal blooms impacting on the Tasmanian salmonid aquaculture industry. We aim to define through a combination of laboratory culture exposure and live cage bioassay experiments the minimum cell concentrations of harmful microalgae (Karenia, Heterosigma, Noctiluca, Chaetoceros) that can cause salmonid mortalities or are a factor in compromising fish health or reducing fish farm productivity. The diagnostic pathology and fish behaviour caused by different harmful algal taxa will be carefully documented to assist fish health inspectors in the routine diagnosis of algal toxicosis ot compromised fish health. Ultimately, this information will be integrated into a risk assessment strategy for the Tasmanian salmonid industry to manage fish stocks during times of harmful algal bloom events.Read moreRead less
Synergistic interactions between reactive oxygen species, free fatty acids and neurotoxins as the fish-killing mechanism of Australian gymnodinioid dinoflagellates. Provide the scientific basis for sound management and mitigation strategies to prevent algal bloom impacts on aquaculture, fisheries and the environment.
The making of a sea shell: function and evolution of genes encoding calcareous architectures of phenomenal strength, purity and beauty. The mollusc shell is composed of microscopic layers of tabular calcium carbonate crystals and thin sheets of proteins with precise nanoscale architectures. This configuration produces a high-performance composite material that exceeds the present capabilities of human engineering. This integrated study will elucidate the molecular mechanisms controlling the fab ....The making of a sea shell: function and evolution of genes encoding calcareous architectures of phenomenal strength, purity and beauty. The mollusc shell is composed of microscopic layers of tabular calcium carbonate crystals and thin sheets of proteins with precise nanoscale architectures. This configuration produces a high-performance composite material that exceeds the present capabilities of human engineering. This integrated study will elucidate the molecular mechanisms controlling the fabrication of these architectures. This knowledge will contribute significantly to the development of materials for advanced electronics and energy transducers, human bone therapeutics and marine?based products such as pearls and cements, through the identification of genes underlying biofabrication networks and the development of in vitro bioproduction systems. Read moreRead less