The multiplexed diagnosis of arbovirus infections using combinatorial probes. Viruses that cause serious diseases such as hemorrhagic fever or encephalitis must be quickly identified. Diagnostic tests based on DNA hybridisation are accurate and can be rapid but they are expensive. We will test a method for simplifying DNA tests and increasing their capabilities. DNA probes for detecting arboviruses will be designed at the ANU using new bioinformatic methods and their reliability will be model ....The multiplexed diagnosis of arbovirus infections using combinatorial probes. Viruses that cause serious diseases such as hemorrhagic fever or encephalitis must be quickly identified. Diagnostic tests based on DNA hybridisation are accurate and can be rapid but they are expensive. We will test a method for simplifying DNA tests and increasing their capabilities. DNA probes for detecting arboviruses will be designed at the ANU using new bioinformatic methods and their reliability will be modelled using all the available genetic information. Computer predictions will be experimentally tested in the PANBIO laboratory by using the probes to detect viral nucleic acids. The influence of virus genome complexity will be investigatedRead moreRead less
Developing new methods to retrieve and analyse preserved genetic information. This project will position Australia at the leading edge of research into preserved DNA, and will use innovative molecular biology approaches to develop a range of new forensic, archaeological and medical applications. It will build Australian knowledge and scientific capacity by developing core expertise and training personnel in areas important for biosecurity, customs and quarantine, forensics/counter-terrorism, and ....Developing new methods to retrieve and analyse preserved genetic information. This project will position Australia at the leading edge of research into preserved DNA, and will use innovative molecular biology approaches to develop a range of new forensic, archaeological and medical applications. It will build Australian knowledge and scientific capacity by developing core expertise and training personnel in areas important for biosecurity, customs and quarantine, forensics/counter-terrorism, and studies of climate change. It will also create and foster research innovation in molecular biology with spin-offs for evolution, archaeology, medical and conservation biology research, and will also encourage involvement with the rapidly expanding field of genomics and bioinformatics.Read moreRead less
Novel bioinformatics approaches for biological inference from comparative genomics data. Unlocking the potential of the human and other genome sequences depends almost entirely upon comparative genomics techniques. We will develop powerful bioinformatic models, implemented as high-performance computing solutions, for the examination of gene sequences. Improving these models, which represent the initial building block for all comparative genomics techniques, will be beneficial across genomics dep ....Novel bioinformatics approaches for biological inference from comparative genomics data. Unlocking the potential of the human and other genome sequences depends almost entirely upon comparative genomics techniques. We will develop powerful bioinformatic models, implemented as high-performance computing solutions, for the examination of gene sequences. Improving these models, which represent the initial building block for all comparative genomics techniques, will be beneficial across genomics dependent industries. A major outcome from this work will be an integrated software/hardware product optimised for statistical examination of very large-scale genomics data.Read moreRead less
The big flood: will it happen again? If we could better predict the frequency of extreme flood events, would we be better prepared to safeguard human lives and settlements? This project provides a time-line of flood activity in the south east Queensland region extending back thousands of years using state-of-the-art dating techniques and seeks to identifiy those settlements most at risk.
Landscape evolution, environmental change and human occupation history of Lake George - an outstanding natural archive. This project will study the environmental and human history of Lake George, where sand and gravel are mined to supply the Canberra region's construction industry. The project will investigate past vegetation and climate changes, lake level fluctuations, groundwater flow, sediment deposition, archaeology and sustainable resource management outcomes.
From ancient to modern environments in southeastern Australia: evidence from the unique natural archives of Lake George. Lake George is an outstanding natural archive - it contains the longest continuous sedimentary record of any Australian lake and has a long, unresolved human occupation history. It also supplies 80 per cent of sand used in the Canberra region construction industry. This multidisciplinary study aims to determine the sedimentary, vegetation, climatic, hydrological, tectonic and ....From ancient to modern environments in southeastern Australia: evidence from the unique natural archives of Lake George. Lake George is an outstanding natural archive - it contains the longest continuous sedimentary record of any Australian lake and has a long, unresolved human occupation history. It also supplies 80 per cent of sand used in the Canberra region construction industry. This multidisciplinary study aims to determine the sedimentary, vegetation, climatic, hydrological, tectonic and archaeological history of the area, including application of cutting-edge dating methods. Project outcomes aim to increase knowledge of landscape evolution and human history in eastern Australia from an improved understanding of the responses of Lake George to past and future climate change and human impact, as well as optimising sustainable extraction of sand and gravel.Read moreRead less