Prenatal Repeat Corticosteroids In Women At Risk Of Preterm Birth For Improving Neonatal Health - An Individual Patient Data Review
Funder
National Health and Medical Research Council
Funding Amount
$461,063.00
Summary
Giving repeat doses of prenatal corticosteroids to women at high risk of preterm birth reduces the risk of their babies having serivous health problems in the early weeks of life. It is unclear what dose, number of doses and interval between doses of corticosteroids is optimal. This review will determine if and how individual women should be treated with repeat corticosteroids to improve the health of their baby born too soon.
The Benefits And Harms Associated With Breast Cancer Screening In The Australian Context.
Funder
National Health and Medical Research Council
Funding Amount
$80,222.00
Summary
Australia is caught in a dilemma. Breast screening is well-established however there has been fierce debate about the value of screening programmes. I will determine the frequency of benefit and harm due to breast screening programs in Australia to better understand the true extent of overdiagnosis and overtreatment. Based on this information, I will make recommendations about how breast screening should be provided in Australia in future and clearly communicate this information to the community
Use And Adequacy Of Diabetic Retinopathy Screening: A Whole Population Linked Data Study
Funder
National Health and Medical Research Council
Funding Amount
$219,382.00
Summary
Diabetes and its health complications are major public health issues presently facing Australia. Currently, around 7% of Australians have diabetes and it is estimated that 300 million people will be diabetic within 20-years. One major complication of diabetes is diabetic retinopathy, which is the most common cause of blindness in working-age adults. Although early treatment can prevent vision loss from diabetic retinopathy, often there are no visual symptoms until the condition is more advanced ....Diabetes and its health complications are major public health issues presently facing Australia. Currently, around 7% of Australians have diabetes and it is estimated that 300 million people will be diabetic within 20-years. One major complication of diabetes is diabetic retinopathy, which is the most common cause of blindness in working-age adults. Although early treatment can prevent vision loss from diabetic retinopathy, often there are no visual symptoms until the condition is more advanced and less treatable. Consequently, it is vital that people with diabetes have their eyes examined regularly. We aim to investigate the use of eye services by people with diabetes. The WA Data Linkage System provides the unique opportunity to efficiently examine the benefits of specialist eye care in diabetics within WA over a 17-year period. The study period encompasses the introduction of NHMRC guidelines for diabetic retinopathy screening in 1997. This will enable us to examine the effectiveness of these guidelines in increasing ophthalmic services use by people with diabetes. Evaluating these trends will provide important data on the effectiveness of policy and NHMRC guidelines in improving diabetic eye care, which has never been comprehensively investigated. Early intervention can prevent and delay vision loss from diabetic retinopathy, substantially reducing the personal and community burden from diabetes. The identification of poorly screened groups will enable more targeted programs to improve the use of ophthalmic series, which in turn may reduce the risk of: i) eye surgery related to diabetes, ii) injury resulting from diabetes-related vision disorder or iii) blindness. The feasibility of using linked health data to evaluate eye screening in diabetics will enable future work addressing processes of care in the prevention of other diabetic complications to be undertaken quickly and cost-effectively.Read moreRead less
A Community-based Cluster Randomized Controlled Trial In Rural Bangladesh To Evaluate The Impact Of The Use Of Iron/folic Acid Supplements Early In Pregnancy On The Risk Of Neonatal MortalityBACKGROUND An Effective Program Of Antenatal Iron/folic Ac
Funder
National Health and Medical Research Council
Funding Amount
$2,564,922.00
Summary
This community-based trial in rural Bangladesh will determine if iron/folic acid supplementation commencing in the first trimester of pregnancy significantly reduces newborn deaths, and whether this approach is cost-effective. This trial has the potential to inform international public health policy about the importance of starting antenatal iron/folic acid supplementation early to improve neonatal survival, and to help countries reach their child survival Millennium Development Goal
The WA Safety And Quality Of Surgical Care Project: Improving The Safety, Quality And Provision Of Surgical Care.
Funder
National Health and Medical Research Council
Funding Amount
$583,500.00
Summary
The basis of this application is a three-year project which aims to improve the safety, quality and the provision of surgical care. This application constitutes the core of the WA Safety and Quality of Surgical Care Project (SQSCP), which was established in 1996 to evaluate the clinical epidemiology, health care utilisation, patient safety and health outcomes following admission to hospital for specific surgical and medical procedures in Western Australia (WA). The study will use data from the W ....The basis of this application is a three-year project which aims to improve the safety, quality and the provision of surgical care. This application constitutes the core of the WA Safety and Quality of Surgical Care Project (SQSCP), which was established in 1996 to evaluate the clinical epidemiology, health care utilisation, patient safety and health outcomes following admission to hospital for specific surgical and medical procedures in Western Australia (WA). The study will use data from the WA Data Linkage System, which brings together 15 million records from hospital morbidity, death, cancer, midwives notification and mental health databases. Surgical procedures have been selected for review based on national priorities and after consultation with the WA Branch of the Royal Australasian College of Surgeons (RACS) and other clinical Colleges. This application proposes to continue the core research activities of the SQSCP. A special focus will be on the use of minimally invasive surgical techniques including laparoscopic, endoscopic and endoluminal procedures, which have increased dramatically during the last decade. The study will also evaluate differences in the outcomes of surgical care in rural and metropolitan settings. The findings of the SQSCP will be comprehensively disseminated to surgeons, the RACS, hospital managers, health policy makers and consumers. The rationale of this project is that by providing high quality data on the epidemiology, utilisation and outcomes of surgical care, we will be able to increase the knowledge-base that will contribute to improvements in the safety, quality and provision of surgical care in Australia and internationally. The aims of the SQSCP are consistent with national health priorities and the recommendations of the Taskforce on Quality of Australian Health Care Study, the Australian Council for Safety and Quality in Health Care and the National Institute of Clinical Studies.Read moreRead less
A Population Based Linked Data Analysis Of The Prognostic Determinants Of Out Of Hospital Cardiac Arrest
Funder
National Health and Medical Research Council
Funding Amount
$174,000.00
Summary
Heart disease, resulting in a cardiac arrest, is the largest single cause of death for men and women in Australia, accounting alone for almost a quarter of all deaths. Despite the scope of the problem, there is a paucity of objective data about the factors that determine outcomes in the short-term and long-term. This study will capitalise on the unique research potential of the WA Data Linkage Project to combine the WA Cardiac Arrest Register with existing health service data and death records, ....Heart disease, resulting in a cardiac arrest, is the largest single cause of death for men and women in Australia, accounting alone for almost a quarter of all deaths. Despite the scope of the problem, there is a paucity of objective data about the factors that determine outcomes in the short-term and long-term. This study will capitalise on the unique research potential of the WA Data Linkage Project to combine the WA Cardiac Arrest Register with existing health service data and death records, to describe the outcomes of out-of-hospital cardiac arrest in Perth WA. Both morbidity and mortality will be described and compared to patients with similar health conditions, but who do not experience a cardiac arrest. More specifically this study will address questions such as 'what is the effect of age, gender, pre-existing illness and socio-economic status on survival from out-of-hospital cardiac arrest?' and What is the long-term survival and health status for initial survivors of out-of-hospital cardiac arrest?' This project will both identify those factors associated with best outcome as well as identify a profile of persons who are 'at risk' of experiencing a further cardiac arrest. Such information is important for the evaluation of current resuscitative practices as well as providing the basis for future planning initiatives.Read moreRead less
HIV Treatment As Prevention: A Longitudinal Assessment Of Population Effectiveness
Funder
National Health and Medical Research Council
Funding Amount
$783,160.00
Summary
This project is a large-scale evaluation of an HIV strategy known as ‘treatment as prevention’ (TasP). Through routine and repeat HIV testing for gay men and early treatment initiation following diagnosis, TasP aims to reduce HIV community infection rates. Through the establishment of a large cohort of gay men in NSW and Victoria, this study will track HIV testing, treatment and management to assess the real-world efficacy of TasP for reducing HIV infections among this at-risk population.