Discovery Early Career Researcher Award - Grant ID: DE130100488
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Cellular dynamics of nanoengineered particles. Nanotechnology has the capacity to drive a new wave of biological innovation through engineering materials at the nanoscale. This project will advance understanding of how nanoengineered materials interact with biological systems to enable the development of nanomaterials for future translational research.
Mapping ear morphology to individualised three dimensional audio. The project aims to develop a practical method to derive a listener's individualised Head Related Transfer Functions from two dimensional images of the head and ears. These are essential for generating high-fidelity three dimensional audio. The project will perceptually evaluate and test the proposed system when applied to teleconferencing, surveillance, and navigational guidance.
Individualisation for 3D Audio. The project aim is to allow the general listener to enjoy high-fidelity 3-D sound over headphones. Such 3-D audio is of paramount importance when inter-personal communication requires situational awareness, (eg search and rescue, fire-fighting, and air traffic control). To achieve this, the project aims to address one of the toughest problems in audio signal processing: deriving high-fidelity 3-D audio headphone filters from photos and/or 3D scans of ears. The pro ....Individualisation for 3D Audio. The project aim is to allow the general listener to enjoy high-fidelity 3-D sound over headphones. Such 3-D audio is of paramount importance when inter-personal communication requires situational awareness, (eg search and rescue, fire-fighting, and air traffic control). To achieve this, the project aims to address one of the toughest problems in audio signal processing: deriving high-fidelity 3-D audio headphone filters from photos and/or 3D scans of ears. The project plans to address fundamental research questions in statistical shape and data analysis and to perceptually evaluate the 3-D audio methods developed.Read moreRead less
Nanoscale silicon field-effect transistor diagnostic technology. This project aims to overcome barriers to the implementation of silicon field-effect transistor biosensors. It will investigate the biosensors’ physical and structural properties. This knowledge, combined with technological and conceptual advances, could foster the development of an advanced and translational point-of-care diagnostic technology to rapidly and sensitively detect malignant tissues. Such technology would have commerci ....Nanoscale silicon field-effect transistor diagnostic technology. This project aims to overcome barriers to the implementation of silicon field-effect transistor biosensors. It will investigate the biosensors’ physical and structural properties. This knowledge, combined with technological and conceptual advances, could foster the development of an advanced and translational point-of-care diagnostic technology to rapidly and sensitively detect malignant tissues. Such technology would have commercial potential and important societal benefits.Read moreRead less
Physics-informed Computational Framework for Optimised Microfluidic Systems. The miniaturisation of chemical and biological processes requires microfluidic tools for the precise manipulation of complex fluids at the microscale. This project aims to integrate new computational methods that enable unprecedented control over the design and optimisation of these tools. The project will deliver a cornerstone framework to elucidate the complex microscopic fluid physics that currently poses a challenge ....Physics-informed Computational Framework for Optimised Microfluidic Systems. The miniaturisation of chemical and biological processes requires microfluidic tools for the precise manipulation of complex fluids at the microscale. This project aims to integrate new computational methods that enable unprecedented control over the design and optimisation of these tools. The project will deliver a cornerstone framework to elucidate the complex microscopic fluid physics that currently poses a challenge for the advancement of microfluidic technologies. The outcomes of this project will establish physical principles to guide the design of microfluidic systems and provide the computational capabilities that can potentially transform the way researchers and engineers design, optimise and use microfluidic technologies.Read moreRead less
The role of internal wave-driven near-bed turbulent dynamics in coastal ocean sediment mobilisation. This project will determine the process of internal wave-driven sediment resuspension and transport in the coastal ocean. This will be achieved by using a combination of field observations and numerical modelling, at two diverse but representative Australian coastal regions where nonlinear internal waves dominate the dynamics. The study has significant application to the offshore oil and gas indu ....The role of internal wave-driven near-bed turbulent dynamics in coastal ocean sediment mobilisation. This project will determine the process of internal wave-driven sediment resuspension and transport in the coastal ocean. This will be achieved by using a combination of field observations and numerical modelling, at two diverse but representative Australian coastal regions where nonlinear internal waves dominate the dynamics. The study has significant application to the offshore oil and gas industry engineering design and operations as well as to environmental management of the coastal ocean ecosystems. This project will achieve a process understanding and create predictive tools describing sediment resuspension and transport for use by industry and marine managers.Read moreRead less
Engineering the convergence of telecare and telehealth. This project will design a wrist-worn pendant that represents the convergence of telecare (fall detection and personal alarm pendants) and telehealth (remote management of chronic disease). The system has the potential to be retro-fitted to 100,000s of telecare systems deployed by an industry partner and to herald a new form of low-cost patient monitoring.
High-resolution elastography – Using optical micro-imaging of tissue mechanics to identify disease. Optical elastography, the probing of tissue’s micro-mechanical properties using optical imaging, offers new tools in surgery and pathology to improve differentiation of tissues. This project lays the groundwork for optical elastography to become a new medical micro-imaging modality by removing impediments to progress in this rapidly emerging field. On the micro-scale, between the scales of cells a ....High-resolution elastography – Using optical micro-imaging of tissue mechanics to identify disease. Optical elastography, the probing of tissue’s micro-mechanical properties using optical imaging, offers new tools in surgery and pathology to improve differentiation of tissues. This project lays the groundwork for optical elastography to become a new medical micro-imaging modality by removing impediments to progress in this rapidly emerging field. On the micro-scale, between the scales of cells and organs. This project will elucidate the origins of tissue mechanical contrast and determine limits on its measurement. It will develop a suite of probes: noncontact, endoscopic and needle, to enable access to all tissues in the body. To progress toward a new modality and inform our research, the project will test our tools on breast cancer tissues and burn scars.Read moreRead less
Supercritical-microfluidics technology for targeted delivery to the colon. This research will develop nanosystems to target delivery of drugs to the colon. Our nanosystems will permit the combination of clinically used chemotherapy drugs within a single dosage form. This will improve the efficiency of delivery to the colon while reducing unwanted side-effects. A novel supercritical microfluidics system will be developed to produce therapeutic nano-carriers in a continuous mode with lower labour ....Supercritical-microfluidics technology for targeted delivery to the colon. This research will develop nanosystems to target delivery of drugs to the colon. Our nanosystems will permit the combination of clinically used chemotherapy drugs within a single dosage form. This will improve the efficiency of delivery to the colon while reducing unwanted side-effects. A novel supercritical microfluidics system will be developed to produce therapeutic nano-carriers in a continuous mode with lower labour requirement, higher production rate and better quality control than conventional production methods. The new process will combine benefits from both supercritical fluid technology (green process) and microfluidics (high mass & heat transfer).Read moreRead less
Efficient learning from multiple brain imaging data sets. Brain imaging data analysis methods have proven to be very effective in the study of brain functions and the identification of brain disorders because they minimise the modelling assumptions on the underlying structure of the problem. Analysis of multiple brain imaging data sets, either of the same modality as in multitask or multisubject data sets or from different modalities as in the case of data fusion, is a challenging problem in bi ....Efficient learning from multiple brain imaging data sets. Brain imaging data analysis methods have proven to be very effective in the study of brain functions and the identification of brain disorders because they minimise the modelling assumptions on the underlying structure of the problem. Analysis of multiple brain imaging data sets, either of the same modality as in multitask or multisubject data sets or from different modalities as in the case of data fusion, is a challenging problem in biomedical image analysis. This project will lead to fundamental contributions as well as techniques that address both problems: extraction of relevant features information from multisubject brain imaging data sets of the same modality or from fusion of brain imaging data sets collected from multimodalities.Read moreRead less