Magnetically controlled drug release from tissue scaffolds for the treatment of acute burns. Severe skin burns are frequently associated with functionally disabling scarring and the risk of death. New magnetically activated wound seals for the treatment of acute burns will be developed that reduce the need for frequent painful dressing changes and hence facilitate rapid healing with a significantly reduced chance of scarring.
Nanoparticles to combat cellular dysfunction. This project aims to design, synthesise and characterise nanoparticles that can mediate the adverse effects of reactive oxygen species. The project expects to develop nanoparticles with tailored chemical functionality to modulate the concentration of reactive oxygen species and develop a platform technology for addressing conditions where reactive species are overproduced. The project will research how nanoparticles’ physicochemical properties affect ....Nanoparticles to combat cellular dysfunction. This project aims to design, synthesise and characterise nanoparticles that can mediate the adverse effects of reactive oxygen species. The project expects to develop nanoparticles with tailored chemical functionality to modulate the concentration of reactive oxygen species and develop a platform technology for addressing conditions where reactive species are overproduced. The project will research how nanoparticles’ physicochemical properties affect their activity, and how they affect cellular function, tissue morphology and particle transport in a biological milieu. The project is expected to benefit the advanced manufacturing, veterinary and medical sectors and could lead to new chemotherapeutics.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE130100488
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Cellular dynamics of nanoengineered particles. Nanotechnology has the capacity to drive a new wave of biological innovation through engineering materials at the nanoscale. This project will advance understanding of how nanoengineered materials interact with biological systems to enable the development of nanomaterials for future translational research.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989567
Funder
Australian Research Council
Funding Amount
$500,000.00
Summary
State of the Art Surface Characterisation Facility for the Sydney Basin. Many of the grand challenges of our time, including finding alternative sources of energy, maximizing our current supply of natural resources, identifying and treating pollution in general, and in water in particular, and developing therapies and biomaterials that enable the personalisation of therapies to each individual are being solved using developments in the molecular sciences. Pivotal to the success of such research ....State of the Art Surface Characterisation Facility for the Sydney Basin. Many of the grand challenges of our time, including finding alternative sources of energy, maximizing our current supply of natural resources, identifying and treating pollution in general, and in water in particular, and developing therapies and biomaterials that enable the personalisation of therapies to each individual are being solved using developments in the molecular sciences. Pivotal to the success of such research is to understand materials and surfaces at the molecular level. The request is to purchase surface analysis instrumentation which will dramatically enhance the ability of scientists around Australia understand how to develop solutions to these grand challenges.Read moreRead less
ARC Centre of Excellence in Convergent Bio-Nano Science and Technology. The CoE in Convergent Bio-Nano Science &Technology comprises a multi-disciplinary team focused on research aiming to understand and control the interface of materials with biological systems. The Centre will exploit knowledge of the bio-nano interface to design materials that transport and deliver vaccines, drugs and gene therapy agents, and to design new diagnostic agents and devices. Nanomedicines are on the cusp of revol ....ARC Centre of Excellence in Convergent Bio-Nano Science and Technology. The CoE in Convergent Bio-Nano Science &Technology comprises a multi-disciplinary team focused on research aiming to understand and control the interface of materials with biological systems. The Centre will exploit knowledge of the bio-nano interface to design materials that transport and deliver vaccines, drugs and gene therapy agents, and to design new diagnostic agents and devices. Nanomedicines are on the cusp of revolutionizing diagnosis and therapy in many diseases. The CoE will be the focus of bio-nano research activity in Australia, uniting universities, research agencies, institutes and companies. The expected outcomes are better diagnostic and therapeutic tools designed via an enhanced understanding of the bio-nano-interface.Read moreRead less
New Strategies for Monitoring DNA-Anticancer Drug Interactions. The highly successful cisplatin works by binding to DNA and partially unwinding or bending the DNA. As a consequence of the success if cisplatin, alternative anticancer drugs are being developed with reduced side effects for patients. One of the bottom necks in the development of alternative drugs is rapid screening of the efficacy on new leads. The proposed research will develop new technologies for monitoring DNA-drug binding, ....New Strategies for Monitoring DNA-Anticancer Drug Interactions. The highly successful cisplatin works by binding to DNA and partially unwinding or bending the DNA. As a consequence of the success if cisplatin, alternative anticancer drugs are being developed with reduced side effects for patients. One of the bottom necks in the development of alternative drugs is rapid screening of the efficacy on new leads. The proposed research will develop new technologies for monitoring DNA-drug binding, DNA damage and DNA repair using novel DNA biosensors. the novelty of the biosensor technology will be to use the modulation of charge transfer through DNA as a method for determining the structural changes that occur in DNA due to these events occurring.Read moreRead less
Skin penetration of nanoparticles promoted by particle design, formulation and application method. This project seeks to better define the determinants of nanoparticle skin penetration and subsequent disposition in the body. The data would be used to guide minimal skin penetration of 'undesirable' nanoparticles and the properties required of 'safe' nanoparticles to enable effective human skin delivery in cosmetic and dermatological products.
Engineering layered double hydroxide nanoparticles toward an efficient targeted clinical delivery system. This project will develop a more effective drug delivery system using clay nanoparticles and biofriendly serum proteins. Outcomes from this project will provide a tremendous opportunity for potent therapies of cancers, vasculature and neuronal diseases, and place Australia at the forefront of nanotechnology drug delivery research.
From Nanostructured Catalysts to Process Innovation. The results of this research will help to advance the fundamental scientific understanding of industrially important chemical reactions and give clear leads as to how to improve them. In particular, new catalysts (i.e. agents that increase the speed and selectivity of chemical reactions) will be generated and the first steps towards process innovation will be taken, using high-throughput equipment unique in the Southern Hemisphere. These new c ....From Nanostructured Catalysts to Process Innovation. The results of this research will help to advance the fundamental scientific understanding of industrially important chemical reactions and give clear leads as to how to improve them. In particular, new catalysts (i.e. agents that increase the speed and selectivity of chemical reactions) will be generated and the first steps towards process innovation will be taken, using high-throughput equipment unique in the Southern Hemisphere. These new catalysts will be the basis for the design of new and/or improved industrial processes that will be ?greener?, safer, use fewer resources, produce less waste and are generally more efficient and effective. As a result the Australian chemicals industry will be more competitive.Read moreRead less
Molecular Recognition in Chiral Ionic Liquids as Basis for the Design and Synthesis of New Enantioselective Heterogeneous Catalysts and Membranes. Molecules that can exist as mirror images, each with different, e.g., beneficial vs. toxic properties, underpin the pharmaceutical industry and increasingly new highly selective pesticides, and flavours/fragrances.
Current commercial pathways often make mixtures of the mirror images that then need to be separated laboriously. These routes are ineffic ....Molecular Recognition in Chiral Ionic Liquids as Basis for the Design and Synthesis of New Enantioselective Heterogeneous Catalysts and Membranes. Molecules that can exist as mirror images, each with different, e.g., beneficial vs. toxic properties, underpin the pharmaceutical industry and increasingly new highly selective pesticides, and flavours/fragrances.
Current commercial pathways often make mixtures of the mirror images that then need to be separated laboriously. These routes are inefficient, creating waste and use resources poorly.
We aim to create solutions for these problems, using supported thin films of special, new types of salts that are liquid at room temperature, and which have other unusual chemical properties that make them ideally suited to enable efficient conversions.Read moreRead less