Linkage Infrastructure, Equipment And Facilities - Grant ID: LE200100123
Funder
Australian Research Council
Funding Amount
$1,100,000.00
Summary
The Digitisation Centre of Western Australia (Phase 1). All five Western Australian Universities, the WA State Library and the WA Museum will collaborate to establish a world-class archival quality Digitisation Centre. There is no existing facility of this kind in WA. During this 12 month project all digitisation equipment will be acquired, installed and used to digitise a diverse range of cultural objects so as to ensure its ability to address the full spectrum of research needs. The Digitisati ....The Digitisation Centre of Western Australia (Phase 1). All five Western Australian Universities, the WA State Library and the WA Museum will collaborate to establish a world-class archival quality Digitisation Centre. There is no existing facility of this kind in WA. During this 12 month project all digitisation equipment will be acquired, installed and used to digitise a diverse range of cultural objects so as to ensure its ability to address the full spectrum of research needs. The Digitisation Centre will form a major piece of national research infrastructure with a prominent international profile and significance. The Centre will have the capacity to digitise all significant Humanities, Arts and Social Sciences (HASS) research collections held by participating institutions within a decade.Read moreRead less
Structure and dynamics of a multiprotein-mRNA complex involved in the regulation of gene expression. RNA/protein interactions are now recognised as a major control point in the regulation of gene-expression. Proteins such as HuR and the poly(C)-binding proteins (PCBPs) act to stabilise and transport specific messenger (m)RNAs, and thus determine their translation levels. In contrast to such an important function, very little is known about these protein/mRNA interactions at an atomic level. The ....Structure and dynamics of a multiprotein-mRNA complex involved in the regulation of gene expression. RNA/protein interactions are now recognised as a major control point in the regulation of gene-expression. Proteins such as HuR and the poly(C)-binding proteins (PCBPs) act to stabilise and transport specific messenger (m)RNAs, and thus determine their translation levels. In contrast to such an important function, very little is known about these protein/mRNA interactions at an atomic level. The current study will investigate the structural and biophysical properties of a recently discovered HuR/PCBP/mRNA complex implicated in the regulation of androgen receptor expression. This information has the potential to assist in the development of drugs to reduce AR expression in prostate cancer.Read moreRead less
Magnetically controlled drug release from tissue scaffolds for the treatment of acute burns. Severe skin burns are frequently associated with functionally disabling scarring and the risk of death. New magnetically activated wound seals for the treatment of acute burns will be developed that reduce the need for frequent painful dressing changes and hence facilitate rapid healing with a significantly reduced chance of scarring.
Broad spectrum nanomedicine for Meningitis treatment. Brain inflammatory diseases are among the top ten infectious causes of death. The project aims to provide Australian doctors with a superior alternative of treating infections that do not respond to conventional antibiotics. The nanomedicine developed will reduce the burden of hospital and boost Australia economy in the biomedical sector.
Everyday Heritage. This project aims to uncover everyday but overlooked forms of Australian heritage. Working collaboratively to bridge academic and industry practice, it seeks to develop innovative methods with outcomes expected to include enhanced collaboration between heritage, digital humanities, and historical research, and new resources for communities and the heritage sector. This should provide significant social and cultural benefits such as more inclusive forms of heritage, and broader ....Everyday Heritage. This project aims to uncover everyday but overlooked forms of Australian heritage. Working collaboratively to bridge academic and industry practice, it seeks to develop innovative methods with outcomes expected to include enhanced collaboration between heritage, digital humanities, and historical research, and new resources for communities and the heritage sector. This should provide significant social and cultural benefits such as more inclusive forms of heritage, and broader intellectual and practical understandings of shared history and citizenship. The project will promote public debate on the role of the past in modern Australia through a range of new forms of history and heritage, digital resources and heritage management tools.
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Prediction of Sea Level Change around Australia and its Calibration and Validation by Satellite-Geodetic Measurements. The redistribution of mass and loading due to deglaciation will change the gravity field, spin axis and centre of mass of the Earth. As such, global sea level will not rise by the same amount in all places, and will even fall in some. This project will extend our realistic Earth model, constructed from a previous ARC grant, to simulate such changes in sea level. These simulat ....Prediction of Sea Level Change around Australia and its Calibration and Validation by Satellite-Geodetic Measurements. The redistribution of mass and loading due to deglaciation will change the gravity field, spin axis and centre of mass of the Earth. As such, global sea level will not rise by the same amount in all places, and will even fall in some. This project will extend our realistic Earth model, constructed from a previous ARC grant, to simulate such changes in sea level. These simulated values will be compared with contemporary estimates of ice mass balance and temporal gravity changes measured by satellite geodesy. Ultimately, this will allow for more informed management of sea level change in Australasia.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL200100220
Funder
Australian Research Council
Funding Amount
$3,364,492.00
Summary
Understanding host-microbiome signalling axes in ageing. Ageing is an inevitable biological phenomenon and is characterised by alterations in multiple biochemical, immunological and mechanical processes, which are influenced by the gut bacteria. Poor ageing exerts a heavy socioeconomic burden both nationally and globally. The aim of this proposal is to deepen understanding of host-microbiome signalling in ageing by bringing together next generation sequencing technologies to characterise age-ass ....Understanding host-microbiome signalling axes in ageing. Ageing is an inevitable biological phenomenon and is characterised by alterations in multiple biochemical, immunological and mechanical processes, which are influenced by the gut bacteria. Poor ageing exerts a heavy socioeconomic burden both nationally and globally. The aim of this proposal is to deepen understanding of host-microbiome signalling in ageing by bringing together next generation sequencing technologies to characterise age-associated change in gut bacterial composition, metabolic profiling to identify changes in functionality of the ageing microbiome and a combination of in vitro and in vivo screening approaches to establish molecular mechanisms. The new knowledge will facilitate development of improved models of health care.Read moreRead less
Oceanic Conditions within Extreme Tropical Cyclones. Australia's tropical and subtropical areas include major infrastructure projects such as the North West shelf oil and gas projects, major mining operations, export ports, natural environments such as the Great Barrier Reef and major tourism industries. All these industries are crucially impacted by extreme tropical cyclones. Despite the importance of these systems, our present understanding of tropical cyclones is incomplete. This project will ....Oceanic Conditions within Extreme Tropical Cyclones. Australia's tropical and subtropical areas include major infrastructure projects such as the North West shelf oil and gas projects, major mining operations, export ports, natural environments such as the Great Barrier Reef and major tourism industries. All these industries are crucially impacted by extreme tropical cyclones. Despite the importance of these systems, our present understanding of tropical cyclones is incomplete. This project will significantly enhance our ability to carry out accurate engineering design of critical offshore infrastructure, as well as marine forecasts in such environments. As such, the project will have major scientific, economic and social benefits for Australia.Read moreRead less
How critical is the inflammatory response in senile plaque formation in a mutant APP transgenic mouse model? The aims of this project is to examine the brains of mice genetically engineered to produce a human mutant form of insoluble beta amyloid protein known to play a critical role in the development of Alzheimer's disease (AD). If the "trigger" for AD is an inflammatory reaction, then the relevant examination of the early stages of senile plaque formation in these animals could lead to pharma ....How critical is the inflammatory response in senile plaque formation in a mutant APP transgenic mouse model? The aims of this project is to examine the brains of mice genetically engineered to produce a human mutant form of insoluble beta amyloid protein known to play a critical role in the development of Alzheimer's disease (AD). If the "trigger" for AD is an inflammatory reaction, then the relevant examination of the early stages of senile plaque formation in these animals could lead to pharmaceutical intervention to delay the development of this debilitating disease. A 5 year delay would significantly reduce the number of people with AD, not only adding years of improved quality of life, but also saving hundreds of millions of Australian dollars in health costs.Read moreRead less
The neurocognitive basis of dual-task co-ordination impairment in Alzheimer’s: defective coordination mechanism or differences in speed of processing? This project explores the effects of age, depression and Alzheimer’s disease on the ability to carry out two tasks at once, to determine whether difficulty doing so is due to slowed mental processing, or to a deficit in a mechanism responsible for task coordination. The project will advance cognitive theory and may help with diagnosis of dementia.