Cellular mechanisms that protect against copper-bound beta-amyloid. This project will investigate some of the brain’s own mechanisms for protecting itself against Alzheimer’s disease. Understanding these mechanisms will be important for developing future therapeutic strategies for treating Alzheimer’s disease.
The Southern Ocean Meridional Overturning Circulation: New observations of vertical mixing. The Southern Ocean and Antarctic Circumpolar Current (ACC) play profound roles in Australian and global climate. However, we know little about how they will be affected by global warming. New velocity observations will tell us how the vertical mixing that contributes to the meridional overturning circulation, and ACC strength, change with the seasons and from year to year. The observations will also gi ....The Southern Ocean Meridional Overturning Circulation: New observations of vertical mixing. The Southern Ocean and Antarctic Circumpolar Current (ACC) play profound roles in Australian and global climate. However, we know little about how they will be affected by global warming. New velocity observations will tell us how the vertical mixing that contributes to the meridional overturning circulation, and ACC strength, change with the seasons and from year to year. The observations will also give us a better understanding of the oceanic and atmospheric processes that drive these changes. This new information will allow climate models to be better constrained so they can more accurately predict changes to Australian and global climate.Read moreRead less
Observations of remarkable eastward flows in the South Indian Ocean. The Indian Ocean drives much of the variability of Australian weather and rainfall and is rapidly evolving. Innovative new observations of remarkable eastward flows in the South Indian Ocean will be combined with models to understand these circulations in a region that has significant economic value for Australia.
Using metallothioneins as a model for understanding cellular and biochemical interactions between neurons and astrocytes within the brain. This research will reveal some of the changes that occur in the relationship between neurons and astrocytes as a consequence injury, aging or disease to the human brain. In national terms, it will contribute to the concerted effort by Australian scientists to understand how and why neurons die following brain injury or in neurodegenerative diseases. These a ....Using metallothioneins as a model for understanding cellular and biochemical interactions between neurons and astrocytes within the brain. This research will reveal some of the changes that occur in the relationship between neurons and astrocytes as a consequence injury, aging or disease to the human brain. In national terms, it will contribute to the concerted effort by Australian scientists to understand how and why neurons die following brain injury or in neurodegenerative diseases. These are significant community issues in both economical and social terms. Furthermore, this research contributes directly to the Designated National Research Priorities by identifying some of the earliest cellular processes associated with aging or disease of the brain, and will provide clues to promoting healthy aging.Read moreRead less
Redefining the metallothionein's role in the injured brain: extracellular metallothioneins play an important role in astrocyte-neuron responses to injury. This project is being performed by an Australian team of researchers who are leaders in this field of research, and has significant national benefits in supporting this team reveal fundamental information on the cellular interactions that occur between astrocytes and neurons within the injured brain. In national terms, it will contribute to th ....Redefining the metallothionein's role in the injured brain: extracellular metallothioneins play an important role in astrocyte-neuron responses to injury. This project is being performed by an Australian team of researchers who are leaders in this field of research, and has significant national benefits in supporting this team reveal fundamental information on the cellular interactions that occur between astrocytes and neurons within the injured brain. In national terms, it will contribute to the concerted effort by Australian scientists to understand how and why neurons die following brain injury or neurodegenerative disease. Furthermore, this research contributes directly to the Designated National Research Priorities by identifying some of the earliest biochemical and cellular processes associated with aging or disease of the brain.Read moreRead less
Winter temperature and salinity profile measurements in the Southern Ocean using elephant seals as ocean sampling platforms. As a result of the paucity of winter data in the Southern Ocean, sophisticated ocean models such as the GFDL MOM are hampered in their ability to properly represent the complex processes in the Antarctic sea ice zone. Elephant seals forage in the Southern Ocean throughout winter, and traverse the water column between 0 and 800 metres many times each day, providing an oppo ....Winter temperature and salinity profile measurements in the Southern Ocean using elephant seals as ocean sampling platforms. As a result of the paucity of winter data in the Southern Ocean, sophisticated ocean models such as the GFDL MOM are hampered in their ability to properly represent the complex processes in the Antarctic sea ice zone. Elephant seals forage in the Southern Ocean throughout winter, and traverse the water column between 0 and 800 metres many times each day, providing an opportunity to collect profiles of temperature and salinity. The resulting data will contribute to oceanographic studies of water mass formation and frontal variability, including comparisons with historical data and assimilation into a complex ocean model.Read moreRead less
Deciphering strategies polar phytoplankton employ to lessen iron limitation. The Southern Ocean is of global importance. It comprises one-third of the global ocean by area and disproportionately absorbs two-thirds of anthropogenic ocean heat and half of anthropogenic carbon dioxide (CO2) emissions even though phytoplankton in this region are chronically iron-limited. This project aims to understand why copper uptake by phytoplankton lessens the effects of iron limitation and how copper substitut ....Deciphering strategies polar phytoplankton employ to lessen iron limitation. The Southern Ocean is of global importance. It comprises one-third of the global ocean by area and disproportionately absorbs two-thirds of anthropogenic ocean heat and half of anthropogenic carbon dioxide (CO2) emissions even though phytoplankton in this region are chronically iron-limited. This project aims to understand why copper uptake by phytoplankton lessens the effects of iron limitation and how copper substitutes for iron. This knowledge is critical for evaluating the impacts and feedbacks between iron and copper in regulating Southern Ocean productivity and ultimately its ability to drawdown atmospheric CO2. The results from this project will facilitate the development of improved ecosystem models and conservation tools.Read moreRead less
Understanding algal bloom microbiome function to improve seafood safety. Current phytoplankton ecological theory is derived primarily from lab cultures, but in nature phytoplankton have unique microbiomes that support their growth and ongoing ocean primary production. This project aims to establish the structure and function of these natural microbiomes, and how they contribute to seafood poisoning caused by bacteria and algal biotoxins. Using advanced flow cytometry with single-cell microbial ....Understanding algal bloom microbiome function to improve seafood safety. Current phytoplankton ecological theory is derived primarily from lab cultures, but in nature phytoplankton have unique microbiomes that support their growth and ongoing ocean primary production. This project aims to establish the structure and function of these natural microbiomes, and how they contribute to seafood poisoning caused by bacteria and algal biotoxins. Using advanced flow cytometry with single-cell microbial profiling, we will sample nano-scale plankton microbiomes and synthetic microbiome phylogenomics to the link between microbiomes and seafood poisoning outbreaks. The outcomes will underpin enhanced predictive modelling of seafood risk to ensure the safety and export security of Australia's $2 billion seafood industry.Read moreRead less
How topography brakes the Antarctic Circumpolar Current. This project aims to observe and simulate the mechanisms that slow the Antarctic Circumpolar Current. The Southern Ocean winds have increased over the last two decades while the transport of the world’s largest current remains steady or slightly decreasing. A possible explanation is negative feedback mechanisms between the winds and transport of the Antarctic Circumpolar Current. This project will observe how eddies carry momentum from the ....How topography brakes the Antarctic Circumpolar Current. This project aims to observe and simulate the mechanisms that slow the Antarctic Circumpolar Current. The Southern Ocean winds have increased over the last two decades while the transport of the world’s largest current remains steady or slightly decreasing. A possible explanation is negative feedback mechanisms between the winds and transport of the Antarctic Circumpolar Current. This project will observe how eddies carry momentum from the wind down to the sea floor and accelerate the deep currents that drag against the rough bottom to put the brakes on this current. Since this current affects Australian rainfall patterns and agricultural output, findings could inform public policy.Read moreRead less
Facilitatory and inhibitory mechanisms during interlimb coordination in young and older adults. The project seeks to understand how people coordinate their limbs and the factors which limit and enhance this capacity. This is of critical importance because coordination is a dominant deficit in aging and in patients suffering brain insult and neurodegenerative diseases. Disruption of this capacity compromises individual work productivity, mobility and independence. Proficient motor functioning is ....Facilitatory and inhibitory mechanisms during interlimb coordination in young and older adults. The project seeks to understand how people coordinate their limbs and the factors which limit and enhance this capacity. This is of critical importance because coordination is a dominant deficit in aging and in patients suffering brain insult and neurodegenerative diseases. Disruption of this capacity compromises individual work productivity, mobility and independence. Proficient motor functioning is an important lifestyle factor as humans age and deficits in coordinated muscle activity will increase the risk of falls which are the leading cause of injury in elderly adults. Identification of changes in brain processes involved in interlimb coordination will allow for the development of strategies to improve motor functions in the aged.Read moreRead less