Barrett's oesophagus (BO) is a condition that arises in some patients with chronic reflux (heartburn) and increases the risk of developing cancer of the oesophagus. However, the exact mechanisms involved in its development are unknown. This project aims to investigate how a protein called sonic hedgehog might be involved using novel cell culturing techniques that allow us to model the growth of oesophageal tissue in the laboratory. This could lead to development of new therapies for treating BO.
The Mechanisms Of Epithelial Cell Survival That Govern Thymus Function
Funder
National Health and Medical Research Council
Funding Amount
$620,967.00
Summary
The thymus is an organ dedicated to the production of crucial immune cells, called T lymphocytes. Cancer treatments, such as radiation or chemotherapy, destroy thymic function and impair immune recovery in patients. We aim to uncover molecular processes that govern the life and death decisions of cells in the thymus. Our goal is to then use this information to develop treatments to protect this critical organ from damage and improve immune recovery following radiation or chemotherapy.
Combining mathematical programming and constraint programming to solve large-scale integrated scheduling problems. This project will target major savings in the airline industry, with resulting benefits for others such as tourism. The efficient use of airline fuel, which will be directly addressed in the project, is very important for the environment. The algorithms developed can improve cost and quality of service for Australian transportation, manufacturing and other industries.
The solut ....Combining mathematical programming and constraint programming to solve large-scale integrated scheduling problems. This project will target major savings in the airline industry, with resulting benefits for others such as tourism. The efficient use of airline fuel, which will be directly addressed in the project, is very important for the environment. The algorithms developed can improve cost and quality of service for Australian transportation, manufacturing and other industries.
The solutions developed within the project will be sold by the industrial partner, CTI, into major companies worldwide, and the technology will be used to develop further products.
Finally the project will extend Australia's lead in constraint programming and expertise in optimisation. This creates a major opportunity for the Australian software industry.
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From Tactical Planning to Operational Control - Bridging the Chasm. All organisations plan, and all organisations suffer from the disruptions that occur when plans are put into practice. Few organisations manage to balance operational control with planning to as to maintain both efficiency and flexibility to deal with the unexpected. This project addresses this requirement for the transportation and logistics industries.
The results discovered within the project will enable the industrial ....From Tactical Planning to Operational Control - Bridging the Chasm. All organisations plan, and all organisations suffer from the disruptions that occur when plans are put into practice. Few organisations manage to balance operational control with planning to as to maintain both efficiency and flexibility to deal with the unexpected. This project addresses this requirement for the transportation and logistics industries.
The results discovered within the project will enable the industrial partner, CTI, to develop solutions for major companies worldwide. The technology will be used to build further optimisation products.
Moreover the project will extend Australia's lead in constraint programming and expertise in optimisation. This creates a major opportunity for Australia's software industry.
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Optimising the design and implementation of public transport priority initiatives. This project strengthens national approaches to a pervasive Australian problem, growing traffic congestion deteriorating liveability, environmental health & economic performance of the cities where most Australians live. Public transport can address these issues but most is provided by buses which are caught up in traffic congestion. This project improves approaches for traffic priority design to improve the eff ....Optimising the design and implementation of public transport priority initiatives. This project strengthens national approaches to a pervasive Australian problem, growing traffic congestion deteriorating liveability, environmental health & economic performance of the cities where most Australians live. Public transport can address these issues but most is provided by buses which are caught up in traffic congestion. This project improves approaches for traffic priority design to improve the effectiveness and efficiency of on-road public transport. It optimises the design of individual and groups of priority treatments and will generate diagnostic tools to better target priority treatments. Findings will better focus Australia's approach to increasingly challenging transport futures.Read moreRead less
Genetic Programs Orchestrated By AP-1 Transcription Factors In Colorectal Cancer Progression
Funder
National Health and Medical Research Council
Funding Amount
$599,941.00
Summary
Colorectal cancer (CRC) is the third most common cancer worldwide. About half of all patients diagnosed with the disease die as a result of its spread in the body. This project will investigate the role that a specific DNA-binding protein plays in orchestrating gene expression programs required for CRCs to spread. The research will provide new insights into underlying mechanisms of CRC progression as well as identify new therapeutic targets for aggressive forms of the disease.
The future of shipping: achieving autonomous navigation. This project aims to develop autonomous decision systems and onshore control stations to support the design and operation of unmanned cargo ships. Blending observations, numerical models, virtual reality and machine learning, the project will develop algorithms for unsupervised navigation and embed these in an advanced ship simulator platform capable of responding to environmental conditions and optimising sea freight transport capabilitie ....The future of shipping: achieving autonomous navigation. This project aims to develop autonomous decision systems and onshore control stations to support the design and operation of unmanned cargo ships. Blending observations, numerical models, virtual reality and machine learning, the project will develop algorithms for unsupervised navigation and embed these in an advanced ship simulator platform capable of responding to environmental conditions and optimising sea freight transport capabilities. The expected outcomes will enable the integration of automated controls in ships, including remote-control capabilities. This will support Australia’s transition towards an autonomous shipping industry, delivering greater reliability, efficiency, productivity and safety.Read moreRead less
The development of active third-generation heavy vehicle aerodynamic drag reducing devices to reduce future transport emissions. The potential for emission reductions through aerodynamic improvements is particularly apparent in long haul heavy vehicle transport. By developing active devices to be fitted to the heavy vehicle trailer of the future this work offers drag reduction potential from current levels of up to 40 per cent. If widely implemented these devices could play a major part in the t ....The development of active third-generation heavy vehicle aerodynamic drag reducing devices to reduce future transport emissions. The potential for emission reductions through aerodynamic improvements is particularly apparent in long haul heavy vehicle transport. By developing active devices to be fitted to the heavy vehicle trailer of the future this work offers drag reduction potential from current levels of up to 40 per cent. If widely implemented these devices could play a major part in the transport sector meeting medium term emissions targets. If successful not only will the project develop unique components, it will support heavy vehicle research and development that is so important to maintaining a strong manufacturing presence in Australia, especially in regional centres, such as Ballarat where Maxitrans has major headquarters. Read moreRead less
Compositional determination of liquefied petroleum gas: Improving engine cold start performance in multipoint LPG-injected engines. Unlike gasoline, the composition of liquefied petroleum gas (LPG) is subject to change depending on a variety of factors including reservoir location and local market pricing. During normal automotive multipoint injection engine operation, closed loop feedback from engine sensors allows the effects of the compositional variations to be overcome and the engine to ope ....Compositional determination of liquefied petroleum gas: Improving engine cold start performance in multipoint LPG-injected engines. Unlike gasoline, the composition of liquefied petroleum gas (LPG) is subject to change depending on a variety of factors including reservoir location and local market pricing. During normal automotive multipoint injection engine operation, closed loop feedback from engine sensors allows the effects of the compositional variations to be overcome and the engine to operate close to optimal levels. However during cold start, the feedback sensors are not operational, and engine performance may deteriorate due to unknown fuel composition - in the worst case the engine may not start at all. This project aims to develop unique methods of estimating the composition of LPG based on existing sensor information to improve performance during cold start.Read moreRead less
Special Research Initiatives - Grant ID: SR0354488
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
Intelligent vehicles and road infrastructure (IVRI). The aims of the network are to integrate the activities of researchers and practitioners in the areas of vehicles and road infrastructure and through cross-disciplinary collaboration apply intelligent control systems to deliver mobility, which is safer for all users, reduces driver stress and environmental impact with increased local manufactured content and improved cost effectiveness. It is of great significance to provide a cohesive solutio ....Intelligent vehicles and road infrastructure (IVRI). The aims of the network are to integrate the activities of researchers and practitioners in the areas of vehicles and road infrastructure and through cross-disciplinary collaboration apply intelligent control systems to deliver mobility, which is safer for all users, reduces driver stress and environmental impact with increased local manufactured content and improved cost effectiveness. It is of great significance to provide a cohesive solution to the transport problem considering all modes, environmental impacts, and economical and social considerations. This project should lead to a report identifying Australia's capability in this sector and a roadmap for a future research network integrating university and industry based research.Read moreRead less