MicroRNAs are small molecules that modulate the expression of most genes and so affect nearly every biological process and pathology although, they were only discovered in humans less than 10 years ago. The bottleneck in discovering the functions of miRNAs is in identifying their molecular targets, the majority of which remain unknown. We aim to comprehensively identify direct target genes of epithelial-specific microRNAs and to confirm a number of them by gene target validation approaches.
Role Of The MiR-200 Target Quaking In Alternative Splicing During EMT And Cancer Progression
Funder
National Health and Medical Research Council
Funding Amount
$443,160.00
Summary
The spread of cancer to other organs involves cancer cells changing to a more aggressive state and is a major cause of cancer related death. MicroRNAs are a class of genes that control whether cancer cells become more aggressive by regulating other genes. In this project we will examine the function of a new microRNA target which controls the cancer cell aggression. The outcome will be a better understanding of how cancers spread and the identification of new therapeutic targets.
Behavioural responses to transport congestion: peak spreading and the more efficient usage of transport infrastructure. Transport networks in cities such as Sydney are at or near capacity. It is no longer socially, environmentally or financially sustainable to continue supplying additional transport infrastructure to meet increased demand. An alternative is to make better use of existing infrastructure by spreading demand more evenly across the day. This project will test behavioural responses t ....Behavioural responses to transport congestion: peak spreading and the more efficient usage of transport infrastructure. Transport networks in cities such as Sydney are at or near capacity. It is no longer socially, environmentally or financially sustainable to continue supplying additional transport infrastructure to meet increased demand. An alternative is to make better use of existing infrastructure by spreading demand more evenly across the day. This project will test behavioural responses to increased congestion and quantify the phenomenon of peak spreading. It will assess economic costs and benefits of using congestion as a signal to encourage more efficient network usage, and examine other tools (e.g. time-based transport pricing) to encourage more efficient use of transport infrastructure.Read moreRead less
Multidimensional evaluation of the overall benefits of voluntary travel behaviour change programs. Voluntary Travel Behaviour Programs (VTBC) offer considerable promise for the management of traffic congestion and reduction in greenhouse gas and air quality emissions from road transport. Research to date has identified two outstanding issues: (1) measurement and evaluation of actual behaviour change and (2) identification of the full benefits and impacts of VTBC. Empirical studies indicate that ....Multidimensional evaluation of the overall benefits of voluntary travel behaviour change programs. Voluntary Travel Behaviour Programs (VTBC) offer considerable promise for the management of traffic congestion and reduction in greenhouse gas and air quality emissions from road transport. Research to date has identified two outstanding issues: (1) measurement and evaluation of actual behaviour change and (2) identification of the full benefits and impacts of VTBC. Empirical studies indicate that many of the benefits fall outside the transport area, including a wide range of socio-economic benefits to individuals and the community. This project will develop a survey tool for assessing benefits and impacts of VTBC within a properly designed and tested evaluation framework.Read moreRead less
Glucose is a critical fuel for living organisms and its presence in the gut triggers nerves that slow stomach emptying. However, little is known of how glucose is actually detected in the gut. We have established that sweet taste molecules of the tongue are also present in the gut, where they may detect glucose. This research will measure the expression and function of these molecules in the gut of humans and mice, and reveal key information on their potential as targets in health and disease.
Exploiting Increased Autophagy In Bronchial Epithelial Cells: A New Therapeutic Approach For Chronic Obstructive Pulmonary Disease (COPD)
Funder
National Health and Medical Research Council
Funding Amount
$724,161.00
Summary
COPD is incurable, a leading cause of death, and new therapies are urgently needed. Autophagy is a cell response to cell stress conditions, however increased autophagy is harmful. We will investigate the association of increased autophagy with COPD and smoking and evaluate therapies that can reduce autophagy, including zinc-related drugs and novel antibiotics that have been modified to lose their anti-bacterial activity.
Targeting MicroRNA-driven Mesenchymal To Epithelial Transition To Suppress Prostate Cancer Metastasis
Funder
National Health and Medical Research Council
Funding Amount
$741,831.00
Summary
Prostate cancer kills ~3,000 men per year in Australia. The development of metastasis is the major cause of prostate cancer-associated death and has limited treatment options. In this study, we will characterise the role of a group of molecules, termed microRNAs, in prostate cancer metastasis. We will also test whether targeting microRNAs using novel drugs termed antagomiRs is an effective strategy to inhibit metastasis and thereby improve prostate cancer mortality.
Dynamic vulnerability of urban road networks. Road transport networks are vital to the economic and social health of our society. Poorly performing networks lead to significant costs and adverse environmental and health impacts. This project will develop methods and tools to predict the effects of network failure through incident-related congestion at bottlenecks (e.g. congestion from accidents, vehicle breakdowns, road works, lane blockages and road closures) and to suggest remedial action plan ....Dynamic vulnerability of urban road networks. Road transport networks are vital to the economic and social health of our society. Poorly performing networks lead to significant costs and adverse environmental and health impacts. This project will develop methods and tools to predict the effects of network failure through incident-related congestion at bottlenecks (e.g. congestion from accidents, vehicle breakdowns, road works, lane blockages and road closures) and to suggest remedial action plans in the case of bottleneck formation. Incident related congestion is responsible for more than 50% of the ($9.4B p.a.) cost of congestion in Australia's major cities.Read moreRead less
Methodology for assessing the vulnerability of multimodal transport networks and developing remedial measures to safeguard network performance. When transport networks fail, the effects on people and the economy can be devastating. The consequences for Hobart of the 1975 Tasman Bridge collapse provide a prime example. Failure may also result from extreme weather and natural disasters, traffic congestion and incidents, commercial failure, human error, or malevolence (such as sabotage). This proje ....Methodology for assessing the vulnerability of multimodal transport networks and developing remedial measures to safeguard network performance. When transport networks fail, the effects on people and the economy can be devastating. The consequences for Hobart of the 1975 Tasman Bridge collapse provide a prime example. Failure may also result from extreme weather and natural disasters, traffic congestion and incidents, commercial failure, human error, or malevolence (such as sabotage). This project will develop a methodology for auditing a transport network to identify where infrastructure failure will have the worst consequences for movement of people and goods. The research will provide tools for planners to determine critical network locations, and devise strategies and remedial measures to safeguard network performance.Read moreRead less
The potential role of transit-oriented development in Australian cities: a critical assessment using a suburban rail corridor. Sustainability in urban development and a reduction in our dependence on the private car for mobility are key concerns in Australia and elsewhere. The results of this research will inform and lead world's best practice in the evaluation and adoption of sustainable transport solutions, especially those related to investment in urban public transport systems, and hence pro ....The potential role of transit-oriented development in Australian cities: a critical assessment using a suburban rail corridor. Sustainability in urban development and a reduction in our dependence on the private car for mobility are key concerns in Australia and elsewhere. The results of this research will inform and lead world's best practice in the evaluation and adoption of sustainable transport solutions, especially those related to investment in urban public transport systems, and hence provide options for planners and developers to minimise the impacts of developments on the environment. The benefits from the project will be in improved planning and design principles and planning tools for transit-oriented urban developments in both inner and outer suburbs in Australian cities.Read moreRead less