Promoting active travel and public transport for a post-pandemic world. In many major cities, COVID-19 stimulated the provision of open streets, pop up bike lanes and widened pedestrian access, prompting unprecedented increases cycling and walking. While this type of infrastructure has always been supported by urban planners and designers, the pandemic has served as a vital inflection point, enabling cities to pursue long-term sustainable transport initiatives, including investment in Active Tra ....Promoting active travel and public transport for a post-pandemic world. In many major cities, COVID-19 stimulated the provision of open streets, pop up bike lanes and widened pedestrian access, prompting unprecedented increases cycling and walking. While this type of infrastructure has always been supported by urban planners and designers, the pandemic has served as a vital inflection point, enabling cities to pursue long-term sustainable transport initiatives, including investment in Active Travel (AT). There is an opportunity to promote AT as part of an integrated transport strategy, and to develop tools for the robust evaluation of AT impacts to inform future investment strategies. This proposal will provide our partner organisation Transport for New South Wales (with the knowledge required to achieve this.
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Inhibition Of Cellcell Actin-based Motility During Poxvirus Infection By The Kinase Inhibitor Glivec
Funder
National Health and Medical Research Council
Funding Amount
$92,950.00
Summary
Although smallpox, one of the deadliest human pathogens, was eradicated in 1980, the current global climate has resulted in fears that smallpox may be used as a biological weapon. Unfortunately the smallpox vaccine poses a serious health hazard to certain people. We have shown that Glivec, a drug used to treat cancer, has potent anti-viral affects on poxvirus replication. This project will test the effectiveness of Glivec in treating smallpox in an animal model and study how it acts.
Integrating Attribute Decision Heuristics into Travel Choice Models that accommodate Risk Attitude and Perceptual Conditioning. This proposal has the specific objective of integrating two disconnected literatures that are having a major influence on the behavioural and statistical performance of discrete choice models in travel choice modelling. These fields are attribute processing strategies and the conditioning of the marginal utility of attributes by risk attitude and perceptual conditioning ....Integrating Attribute Decision Heuristics into Travel Choice Models that accommodate Risk Attitude and Perceptual Conditioning. This proposal has the specific objective of integrating two disconnected literatures that are having a major influence on the behavioural and statistical performance of discrete choice models in travel choice modelling. These fields are attribute processing strategies and the conditioning of the marginal utility of attributes by risk attitude and perceptual conditioning. These two major developments have not been jointly integrated into a behaviourally richer representation of choice making. Given the encouraging evidence from both literatures, the research will determine more precisely the benefits in terms of improved estimates of willingness to pay for specific attributes and also increased predictive power. Read moreRead less
Defining The Mechanism Of Assembly Of Herpes Simplex Virus In The Neuronal Growth Cone And Its Subsequent Exit To Epithelial Cells
Funder
National Health and Medical Research Council
Funding Amount
$774,624.00
Summary
Herpes simplex virus (HSV) causes dormant infection of nerve cell bodies near the spine. It periodically reactivates to be transported along nerves to the skin where it causes oral, genital or neonatal herpes and mediates HIV superinfection. HSV assembles into its final form in the terminal part of the axon just prior to crossing into skin. Elucidating the mechanism of HSV assembly and exit will facilitate new strategies for antiviral agents and immune treatment for HSV and similar viruses.
Wave Climate in the Southern Great Barrier Reef. Sea surface roughness has a major influence on global climate modelling. This project will provide a better understanding of the variability of sea waves in coastal waters. New technology of HF ocean radar can map wave fields over coastal waters and thus fill a gap between the open ocean satellite measurements and the point measurements from wave buoys. In this project we will improve the analysis of the radar echoes to produce sea wave spectra, a ....Wave Climate in the Southern Great Barrier Reef. Sea surface roughness has a major influence on global climate modelling. This project will provide a better understanding of the variability of sea waves in coastal waters. New technology of HF ocean radar can map wave fields over coastal waters and thus fill a gap between the open ocean satellite measurements and the point measurements from wave buoys. In this project we will improve the analysis of the radar echoes to produce sea wave spectra, and evaluate focussing of waves by complex currents on the continental shelf to help improve wave forecasting in coastal waters. The HF radar will be used to experimentally test current theories of wind wave spreading.Read moreRead less
Shape adaptive structures with built-in compact smart material based actuators. Primary Australian aerospace manufacturers are sub-contractors and constantly compete in the global market. Their products are primarily control surfaces, e.g., Boeing 757 and 777 rudders, 737 Krueger flaps. In light of the development of the hingeless control surfaces (HCS) in the smart aircraft wing program in the USA, the economic benefits of this project are very high because (a) it will address the key technolo ....Shape adaptive structures with built-in compact smart material based actuators. Primary Australian aerospace manufacturers are sub-contractors and constantly compete in the global market. Their products are primarily control surfaces, e.g., Boeing 757 and 777 rudders, 737 Krueger flaps. In light of the development of the hingeless control surfaces (HCS) in the smart aircraft wing program in the USA, the economic benefits of this project are very high because (a) it will address the key technological issue identified in the HCS program; and (b) it will enhance Australian manufacturers¡¯ technological standing and input in the design and manufacturing of next generation HCS by providing highly trained people with world-leading niche technology.Read moreRead less
Active shape control of large thin-walled structures using ferroelectric single crystals. Ferroelectric single crystals were invented 5 years ago, and they possess many superior properties compared to conventional piezoelectric materials, particularly the induced strain up to 1.5%, an order higher than conventional materials. This project aims to poineer the application of these new and powerful smart materials as actuators and sensors to shape control of smart structures. The expected outcome ....Active shape control of large thin-walled structures using ferroelectric single crystals. Ferroelectric single crystals were invented 5 years ago, and they possess many superior properties compared to conventional piezoelectric materials, particularly the induced strain up to 1.5%, an order higher than conventional materials. This project aims to poineer the application of these new and powerful smart materials as actuators and sensors to shape control of smart structures. The expected outcomes are (a) a new constitutive theory for the non-linear behaviour of ferroelectric single crystals; (b) a novel definition and formulation for the shape control problem; and (c) an innovative theoretical framework for design optimization of shape control of smart structures using ferroelectric single crystals.Read moreRead less
Morphing flexible structures with lead lanthanum zirconium titanate (PLZT) based optical actuators. Lead lanthanum zirconate titanate (PLZT) materials yield mechanical strains when exposed to near ultraviolet light as a result of combined photovoltaic and converse piezoelectric effects. They offer actuation strain on par with piezoelectric materials and other advantages, such as wireless light-to-mechanical energy transfer, immunity from electrical and magnetic disturbances and fast response wi ....Morphing flexible structures with lead lanthanum zirconium titanate (PLZT) based optical actuators. Lead lanthanum zirconate titanate (PLZT) materials yield mechanical strains when exposed to near ultraviolet light as a result of combined photovoltaic and converse piezoelectric effects. They offer actuation strain on par with piezoelectric materials and other advantages, such as wireless light-to-mechanical energy transfer, immunity from electrical and magnetic disturbances and fast response with the transparent electrode design. This project aims to pioneer the application of PLZT optical actuators in morphing flexible structures leading to development of wireless smart structures technology and opt-electromechanical systems such as medical instruments.Read moreRead less
Assessment and Prediction of Particle Breakage under Cyclic Loading. Every year, transport industries spend millions of dollars to maintain existing tracks suffering excessive settlement due to heavy traffic. In railways, differential settlement and track fouling are mostly due to ballast breakage. Frequent maintenance requires large amounts of quarried ballast causing environmental degradation. Simulation of particle breakage subject to cyclic loading is pioneering fundamental research that wi ....Assessment and Prediction of Particle Breakage under Cyclic Loading. Every year, transport industries spend millions of dollars to maintain existing tracks suffering excessive settlement due to heavy traffic. In railways, differential settlement and track fouling are mostly due to ballast breakage. Frequent maintenance requires large amounts of quarried ballast causing environmental degradation. Simulation of particle breakage subject to cyclic loading is pioneering fundamental research that will have significant impact on the design and maintenance of future rail and road networks. A full understanding of the breakage mechanisms of aggregates will lead to innovative techniques in design and construction, including faster trains carrying heavier loads with reduced maintenance costs.Read moreRead less
Much of the death and suffering caused by cancer is associated with secondary tumours, but alot remains to be learned about how cancer spreads through the patient's body. This project will determine how genes that enable the growth of tumours work with other genes that enable cancer cells to detach from the tumour, enabling them to enter the bloodstream and form secondary tumours in other organs.