Epilepsy: Molecular Basis And Mechanisms In The Era Of Functional Genomics
Funder
National Health and Medical Research Council
Funding Amount
$12,062,533.00
Summary
The team comprises of neurologists with a special interest in epilepsy (both adult and child) molecular geneticists, physiologists and brain imaging specialists. The team leads the world in the discovery of the genetic causes of epilepsy and epilepsy associated with intellectual disability. The team will continue to identify the genes underlying epilepsy, and study how genetic variations result in the development of seizures and will continue to develop advanced imaging techniques for these stud ....The team comprises of neurologists with a special interest in epilepsy (both adult and child) molecular geneticists, physiologists and brain imaging specialists. The team leads the world in the discovery of the genetic causes of epilepsy and epilepsy associated with intellectual disability. The team will continue to identify the genes underlying epilepsy, and study how genetic variations result in the development of seizures and will continue to develop advanced imaging techniques for these studies. This will include extensive laboratory studies, including the development of mice with the exact mutations that we find in the human condition. Stateof-the-art imaging techniques with magnetic resonance and positron emission tomography are used in human subjects to further understand the effects of the mutations on the structure and function of the brain. This will allow deep understanding of how seizures develop and may lead to new diagnostic methods and treatments. The laboratory and clinical aspects of the research are tightly integrated in this internationally leading collaborative program.Read moreRead less
I am a molecular geneticist with a main research focus in the identification and characterisation of genes and molecular pathways involved in intellectual disability and epilepsy.
Identifying Target Genes For Novel Anti-epileptic Therapies In The Mouse
Funder
National Health and Medical Research Council
Funding Amount
$469,802.00
Summary
Epilepsy is a disease which affects 2-4% of the population. There are a wide range of drugs available to treat the condition but there is consistently 30-40% of patients who do not respond well to any of these drugs and who continue to have seizures. The reason that there are no drugs available for these people is that most of the drugs available have been designed along the same principles. A new set of principles is needed to develop new drugs which will be able to treat those people not respo ....Epilepsy is a disease which affects 2-4% of the population. There are a wide range of drugs available to treat the condition but there is consistently 30-40% of patients who do not respond well to any of these drugs and who continue to have seizures. The reason that there are no drugs available for these people is that most of the drugs available have been designed along the same principles. A new set of principles is needed to develop new drugs which will be able to treat those people not responding to current therapy. This project is designed to identify new biologic pathways which may be interrupted with drugs to prevent seizures in people with epilepsy. This project uses a procedure to induce mutations into genes in mice and then screens for mice which do not seize when challenged with a drug which generates seizures in mice. Genetic studies will identify the mutated genes and these will be used as potential targets for new therapies or will identify new biological pathway which should expand the use of future anti-epileptic drugs.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0561231
Funder
Australian Research Council
Funding Amount
$671,715.00
Summary
MRI GRID Computing Facility: Design, Optimisation and Image Processing. The MRI Grid Computing Facility provides the IT infrastructure to achieve effective e-research in the area of magnetic resonance (MR) imaging, a field of neuroscience research that revolutionizes the way brain diseases are identified and treated. The facility consists of a dedicated high performance grid compute engine, distributed visualisation workstations, and distributed data warehouse facilities. Software tools acc ....MRI GRID Computing Facility: Design, Optimisation and Image Processing. The MRI Grid Computing Facility provides the IT infrastructure to achieve effective e-research in the area of magnetic resonance (MR) imaging, a field of neuroscience research that revolutionizes the way brain diseases are identified and treated. The facility consists of a dedicated high performance grid compute engine, distributed visualisation workstations, and distributed data warehouse facilities. Software tools accessible through the Internet will enable researchers to archive, retrieve and exchange data and software; access distributed MR image databases and the latest MR image analysis tools; schedule analysis tasks on the grid compute engine, the outcomes of which will be visualized by the visualization workstations.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100235
Funder
Australian Research Council
Funding Amount
$280,000.00
Summary
Accelerating Australia's large scale video surveillance research programmes. The research to be conducted using this infrastructure will bring immense benefits to Australia in terms of increased levels of public safety and in the protection of critical facilities from terrorism and other crimes, by developing better surveillance systems. This will provide both increases in measurable research outputs and opportunities for Australian business to commercialise these systems. The infrastructure wil ....Accelerating Australia's large scale video surveillance research programmes. The research to be conducted using this infrastructure will bring immense benefits to Australia in terms of increased levels of public safety and in the protection of critical facilities from terrorism and other crimes, by developing better surveillance systems. This will provide both increases in measurable research outputs and opportunities for Australian business to commercialise these systems. The infrastructure will accelerate the pace of surveillance research and development in Australia, enhancing the competitiveness of both Australia's researchers and the businesses that will commercialise these researchers' discoveries.Read moreRead less
Tracking targets in large scale surveillance camera networks. The research is expected to provide a significant boost in the effectiveness of safety and security measures for public facilities and open spaces that are monitored by surveillance cameras. The general public benefits from this through a decreased need for intrusive security measures, and increased deterrence of crime and anti-social behaviour. This capability is in demand worldwide for both public and private camera networks, whose ....Tracking targets in large scale surveillance camera networks. The research is expected to provide a significant boost in the effectiveness of safety and security measures for public facilities and open spaces that are monitored by surveillance cameras. The general public benefits from this through a decreased need for intrusive security measures, and increased deterrence of crime and anti-social behaviour. This capability is in demand worldwide for both public and private camera networks, whose usefulness is currently limited by the difficulty of monitoring them. We therefore anticipate considerable commercial interest in Australia and internationally.
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Space-based space surveillance with robust computer vision algorithms. Space-based space surveillance with robust computer vision algorithms. This project aims to develop computer vision algorithms to detect man-made objects in space. These algorithms function on nanosatellite platforms, enabling space-based space surveillance. This technology is expected to provide always-on monitoring of the Earth's orbit to enhance existing defence infrastructure and protect vital space assets, including comm ....Space-based space surveillance with robust computer vision algorithms. Space-based space surveillance with robust computer vision algorithms. This project aims to develop computer vision algorithms to detect man-made objects in space. These algorithms function on nanosatellite platforms, enabling space-based space surveillance. This technology is expected to provide always-on monitoring of the Earth's orbit to enhance existing defence infrastructure and protect vital space assets, including communications and navigational satellites, in Earth’s orbit from collisions and covert sabotage. Increased space use by government and civilian agencies opens up opportunities for the space industry. This project is expected to develop Australia’s space surveillance capabilities, protect space assets and capture a growing market.Read moreRead less
Statistical Methods of Model Fitting and Segmentation in Computer Vision. Electronic sensors such as cameras and lasers can provide a rich source of information about the position, shape, and motion of objects around us. However, to extract this information in a reliable, automatic, and accurate way requires a sophisticated statistical theory of the process. Example applications include: video surveillance (better automatic detection of moving people and vehicles and of characterising what those ....Statistical Methods of Model Fitting and Segmentation in Computer Vision. Electronic sensors such as cameras and lasers can provide a rich source of information about the position, shape, and motion of objects around us. However, to extract this information in a reliable, automatic, and accurate way requires a sophisticated statistical theory of the process. Example applications include: video surveillance (better automatic detection of moving people and vehicles and of characterising what those people and vehicles are doing), industrial prototyping and inspection (measuring the size and shape of objects), urban planning (laser scanning streetscapes to create computer models of cities), entertainment industry (movie special effects and games), etc. Read moreRead less
Image search for simulator content creation. The World Wide Web contains tens of billions of images, with personal and industrial collections stretching to may times that number. The potential economic value of these image-based resources is enormous, but largely untapped as we have no practical way of recovering the images we need. This project will develop image search technologies which will allow Australian industry to exploit these important resources. Some of the wide variety of possible ....Image search for simulator content creation. The World Wide Web contains tens of billions of images, with personal and industrial collections stretching to may times that number. The potential economic value of these image-based resources is enormous, but largely untapped as we have no practical way of recovering the images we need. This project will develop image search technologies which will allow Australian industry to exploit these important resources. Some of the wide variety of possible applications might include the searching of surveillance video for objects of interest, vision-based guidance of unmanned vehicles, smart-phone and smart-home systems which understand their environments, and stock tracking systems which can detect spoilage.Read moreRead less