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The role of transient DNA methylation on muscular adaptation. Regulation of gene expression is fundamental to all living organisms. This project will utilise the preliminary evidence that DNA methylation, an imprint establishing the phenotype of a specific organ, rapidly drops after an exercise bout, contradicting the dogma that DNA methylation is a locked process.
Extracellular vesicles in the inheritance of acquired traits. This project aims to examine the role of extracellular vesicles (EV) in the transfer of regulatory RNA from somatic cells to germline cells. This project suggests that somatic EVs from the epididymis transfer regulatory RNA to the sperm, and that this RNA exerts its effects in the early embryo of the next generation. This will provide significant benefits, such as a new molecular understanding of heredity that could be key to thriving ....Extracellular vesicles in the inheritance of acquired traits. This project aims to examine the role of extracellular vesicles (EV) in the transfer of regulatory RNA from somatic cells to germline cells. This project suggests that somatic EVs from the epididymis transfer regulatory RNA to the sperm, and that this RNA exerts its effects in the early embryo of the next generation. This will provide significant benefits, such as a new molecular understanding of heredity that could be key to thriving in a changing environment.Read moreRead less
The nature and extent of mammalian transgenerational epigenetic inheritance. This project aims to understand how biological information can be passed from one generation to the next without being encoded in the genes. The results of this study will inform us how this can happen, and shed light on how often it happens in mammals.
System-level characterisation of the siphonophore, Indo-Pacific man o' war. The Indo-Pacific man o' war (bluebottle), is a cnidarian from the siphonophore order. These animals frequent Australian beaches in swarms and cause thousands of stings every year. The project proposes to profile the genome, transcriptome, epigenome, and proteome of the bluebottle to gain insight into its life cycle, its behaviour, and toxins. Expected outcomes include the generation of novel information related to bluebo ....System-level characterisation of the siphonophore, Indo-Pacific man o' war. The Indo-Pacific man o' war (bluebottle), is a cnidarian from the siphonophore order. These animals frequent Australian beaches in swarms and cause thousands of stings every year. The project proposes to profile the genome, transcriptome, epigenome, and proteome of the bluebottle to gain insight into its life cycle, its behaviour, and toxins. Expected outcomes include the generation of novel information related to bluebottle gene regulation and its toxin repertoire, which will be highly beneficial for the design of future sting treatment strategies. Given that the bluebottle is a colony made of functionally specialised polyps, this study will also provide significant novel insight into the origins and evolution of animal multicellularity.Read moreRead less
How is molecular information passed between generations? This project aims to determine the mechanisms responsible for the inheritance of acquired traits. Sometimes the environment can have effects on the phenotype of not only the exposed individual, but also their children and grandchildren. While it is clear that this can occur, what is not clear is the mechanism by which this happens and the frequency at which it happens. This project will combine use of the model organism Caenorhabditis eleg ....How is molecular information passed between generations? This project aims to determine the mechanisms responsible for the inheritance of acquired traits. Sometimes the environment can have effects on the phenotype of not only the exposed individual, but also their children and grandchildren. While it is clear that this can occur, what is not clear is the mechanism by which this happens and the frequency at which it happens. This project will combine use of the model organism Caenorhabditis elegans with biochemistry and structural biology to determine what the molecular mechanism is by which this "transgenerational epigenetic inheritance" occurs.Read moreRead less
Understanding the role of endogenous siRNAs in the maintenance of genomic defenses. The inappropriate expression of retrotransposons can cause increased genomic instability. The underlying molecular pathways that control retrotransposon expression are not known. This project proposes to investigate this question at a molecular level how naturally occurring small endogenous noncoding RNAs (endo-siRNAs) enforce the epigenetic silencing of retrotransposons and examine the likely impact of endo-siRN ....Understanding the role of endogenous siRNAs in the maintenance of genomic defenses. The inappropriate expression of retrotransposons can cause increased genomic instability. The underlying molecular pathways that control retrotransposon expression are not known. This project proposes to investigate this question at a molecular level how naturally occurring small endogenous noncoding RNAs (endo-siRNAs) enforce the epigenetic silencing of retrotransposons and examine the likely impact of endo-siRNAs expression in the packaging and maintenance of retrotransposons. Understanding this fundamental question will advance the scientific knowledge of small RNA functions in our genomic defense systems. Read moreRead less
Radical change in the architecture of a nucleus: loss of typical DNA organisation systems in dinoflagellates. The genetic blueprint of all higher cells is stored in the cell nucleus, and proteins called histones provide the filing system for compactly stacking and organising the cell's DNA. One group of organisms, the dinoflagellate algae, have lost this histone system. This project will provide insight into their alternative DNA management systems.
The molecular mechanism of action of bacterial epigenetic regulators. This project aims to determine the mechanisms of action of a class of bacterial epigenetic regulators. Many bacteria exhibit phase variable expression of genes (random, high frequency on/off switching of expression), typically due to simple DNA repeats within the gene(s) that encode them. Many bacterial species contain phase variable DNA methyltransferases that regulate epigenetics and control expression of distinct sets of pr ....The molecular mechanism of action of bacterial epigenetic regulators. This project aims to determine the mechanisms of action of a class of bacterial epigenetic regulators. Many bacteria exhibit phase variable expression of genes (random, high frequency on/off switching of expression), typically due to simple DNA repeats within the gene(s) that encode them. Many bacterial species contain phase variable DNA methyltransferases that regulate epigenetics and control expression of distinct sets of proteins (phasevarions) via variable methylation of the genome. The precise mechanism of action of these regulators is unknown. Characterisation of these systems will provide better understanding of bacterial gene regulation and adaptation, which will inform biotechnology and vaccine development and could contribute to economic and health advancements.Read moreRead less
Epigenetic regulation of genomic stability and inheritance. Sperm mediate inheritance by transmitting DNA and associated chemical (epigenetic) modifications to offspring. We hypothesise that epigenetic modifications protect DNA from mutations during sperm formation. Using innovative models, our interdisciplinary team will determine whether loss of specific epigenetic modifications permits mutations in sperm and whether these mutations are transmitted to offspring. Our work will contribute to und ....Epigenetic regulation of genomic stability and inheritance. Sperm mediate inheritance by transmitting DNA and associated chemical (epigenetic) modifications to offspring. We hypothesise that epigenetic modifications protect DNA from mutations during sperm formation. Using innovative models, our interdisciplinary team will determine whether loss of specific epigenetic modifications permits mutations in sperm and whether these mutations are transmitted to offspring. Our work will contribute to understanding how new mutations arise in sperm and potentially affect offspring phenotype, adaptation and evolution. As chemicals, drugs and diet can affect epigenetic function, our studies will also contribute to determining how epigenetic inheritance affects environmental, agricultural and healthcare outcomes.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE190101078
Funder
Australian Research Council
Funding Amount
$374,433.00
Summary
Functional role of a novel DNA modification in the adult brain. This project aims to understand how neuronal DNA is modified upon learning and how this impacts memory formation. The project will investigate the combination of different genome-wide sequencing approaches and molecular and cell biological assays to provide new insight into the functional role of a novel DNA modification, N6-methyl-2'-deoxyadenosine in the adult brain. This projects expects to have a major impact on many fields, inc ....Functional role of a novel DNA modification in the adult brain. This project aims to understand how neuronal DNA is modified upon learning and how this impacts memory formation. The project will investigate the combination of different genome-wide sequencing approaches and molecular and cell biological assays to provide new insight into the functional role of a novel DNA modification, N6-methyl-2'-deoxyadenosine in the adult brain. This projects expects to have a major impact on many fields, including neuroscience, evolutionary biology, and genetics, by helping to shape a new way of thinking about gene-environment interactionsRead moreRead less