Discovery Early Career Researcher Award - Grant ID: DE230100730
Funder
Australian Research Council
Funding Amount
$448,000.00
Summary
Strategies to minimise the societal impacts of zoonotic pandemics. The continuing pandemic has had unprecedented effects across society. Population mobility restrictions have been effective in slowing transmission, but are only effective while in place and have dramatic adverse effects. Despite Australia’s relative success, we have lacked a clear national strategy to guide the optimal deployment of such restrictions. During this fellowship, I will use robust software development practices to dev ....Strategies to minimise the societal impacts of zoonotic pandemics. The continuing pandemic has had unprecedented effects across society. Population mobility restrictions have been effective in slowing transmission, but are only effective while in place and have dramatic adverse effects. Despite Australia’s relative success, we have lacked a clear national strategy to guide the optimal deployment of such restrictions. During this fellowship, I will use robust software development practices to develop a unified software platform that integrates semi-mechanistic, particle filter and agent-based methodologies. I will then use this platform to quantify the effects of mobility restrictions and define the optimal strategic response that should be selected based on the characteristics of a newly emerged pathogen.Read moreRead less
Strengthening The Evidence Foundation For Public Health Guidelines
Funder
National Health and Medical Research Council
Funding Amount
$987,647.00
Summary
Public health guidelines should be based on rigorous evidence. If underlying studies are not sound, guidelines will not be credible or implemented. Dietary guidelines have been criticized for being biased. Our group studies bias across the whole research process – from the questions asked to the final publication. This project will measure the influence of bias at all stages in nutrition research in order to improve the evaluation of this research and the evidence base for dietary guidance.
Designing liveable neighbourhoods to support healthy ageing. This project aims to identify whether neighbourhood liveability influences healthy ageing, and the extent to which this association is modified by individual preferences and socioeconomic disadvantage using longitudinal analyses. The research expects to generate new knowledge on urban design that supports healthy ageing, which is mostly derived from cross-sectional studies. Expected outcomes include evidence-based recommendations for i ....Designing liveable neighbourhoods to support healthy ageing. This project aims to identify whether neighbourhood liveability influences healthy ageing, and the extent to which this association is modified by individual preferences and socioeconomic disadvantage using longitudinal analyses. The research expects to generate new knowledge on urban design that supports healthy ageing, which is mostly derived from cross-sectional studies. Expected outcomes include evidence-based recommendations for informing urban design and health policies to support healthy ageing and ageing in place, which is a key government agenda in Australia. This should provide benefits such as the delivery of high quality liveable environments that support healthy ageing and reduced aged care expenditure.Read moreRead less
Networks: New links between spectrum, dynamics, rewirings and applications. Modern network science has transformed the study of complex systems and led to innovations in many disciplines. This project intends to develop breakthrough theories for control of complex networked system behaviour via interventions of the link-rewiring type. New approaches will be developed for non-random, assortative and/or structured networks, which are poorly understood and difficult to deal with, despite being the ....Networks: New links between spectrum, dynamics, rewirings and applications. Modern network science has transformed the study of complex systems and led to innovations in many disciplines. This project intends to develop breakthrough theories for control of complex networked system behaviour via interventions of the link-rewiring type. New approaches will be developed for non-random, assortative and/or structured networks, which are poorly understood and difficult to deal with, despite being the real-world norm and despite their impact. The results will give new insights into epidemic outbreaks and their impact on vulnerable groups (e.g., elderly and indigenous), and provides methods to enforce resilience of infrastructure networks such as power grids, thereby providing significant economic and societal benefits. Read moreRead less
LONGITUDINAL STUDY OF BEHAVIOUR AND EMOTIONAL PROBLEMS IN YOUNG PEOPLE WITH INTELLECTUAL DISABILITIES
Funder
National Health and Medical Research Council
Funding Amount
$761,790.00
Summary
Families caring for young people with intellectual disabilities face major burdens of care if the young person also has serious behaviour problems. These behaviour problems are also costly for our community. This project is intended to assist young people and their carers by providing new information about the factors contributing to these behaviour problems and how they develop over time. The project makes use of an internationally unique follow up study which has followed a group of young peop ....Families caring for young people with intellectual disabilities face major burdens of care if the young person also has serious behaviour problems. These behaviour problems are also costly for our community. This project is intended to assist young people and their carers by providing new information about the factors contributing to these behaviour problems and how they develop over time. The project makes use of an internationally unique follow up study which has followed a group of young people aged 4-18 for the last eight years. The young people are now entering a critical age band facing many changes in their lives such as the possibility of independent living, work challenges, as well as a search for new social relationships and day activities in the post-school period. Also they face increased risk for mental health problems which most commonly emerge in this age group, particularly psychosis and depression. This project promises to determine how the young people cope with these challenges and what steps our community needs to make to assist them and their families to reach an optimal adjustment.Read moreRead less
A Longitudinal Study Of Psychopathology In People With Intellectual Disability
Funder
National Health and Medical Research Council
Funding Amount
$999,803.00
Summary
This project will further develop the research opportunities of an internationally unique 15 year follow up study of the mental health of young Australians with ID. We have shown that this group has 2-3 times the risk of suffering serious emotional and behavioural problems that are an added heavy burden on the individual, their family and carers and the community. These problems often are not recognised but are as common as schizophrenia in the community. The study will continue to use a combina ....This project will further develop the research opportunities of an internationally unique 15 year follow up study of the mental health of young Australians with ID. We have shown that this group has 2-3 times the risk of suffering serious emotional and behavioural problems that are an added heavy burden on the individual, their family and carers and the community. These problems often are not recognised but are as common as schizophrenia in the community. The study will continue to use a combination of questionnaire survey and in depth interviews of the young adults and their families or carers to track the course of their mental health. The study commenced in 1990 with nearly 1000 young people with ID aged 4-18 years and their progress has been reviewed every 2-3 years in over 75% of the original group. During the next 5 years we plan to follow their mental health during the critical stage of young adult life. During this time there is the greatest risk of mental illnesses such as depression and schizophrenia and the stresses of adjusting to new daily occupations, independent living or residential care and social contact away from the family. We will be able to study the specific emotional and behavioural problems faced by young adults with the main known causes of ID such as Down, Fragile X, Prader Willi and William Syndromes, as well as those who have autism. The great benefit of a long term follow up study is that it allows us to study the links between earlier family environmental, psychological and biological factors and subsequent mental health problems. We can also demonstrate the impact that mental illness in a young person with ID has on the family and parental mental health. The findings have implications for better diagnosis, improved care and management, early intervention and prevention of these common severe and under recognized mental health problems in this disadvantaged group of young Australians and their families and carers.Read moreRead less
Exploiting Database Technologies for the Visualization and Analysis of Measured and Simulated Plant Structures in Bioinformatics. The project will contribute to both bioinformatics and database research at both the national and international levels, although this project is specifically focusing on plant architecture but it has great potential other fields such as solving computationally difficult problems of branching in nature such as DNA and crystal related research. The results of this resea ....Exploiting Database Technologies for the Visualization and Analysis of Measured and Simulated Plant Structures in Bioinformatics. The project will contribute to both bioinformatics and database research at both the national and international levels, although this project is specifically focusing on plant architecture but it has great potential other fields such as solving computationally difficult problems of branching in nature such as DNA and crystal related research. The results of this research can be applied to all kinds of plants such as rice, cotton, rose etc.Read moreRead less
Understanding The Sources Of Campylobacter In Australia
Funder
National Health and Medical Research Council
Funding Amount
$546,720.00
Summary
Campylobacter is a key cause of foodborne disease in Australia, with rates of illness amongst the highest in the world. Our project brings together academic, government and industry partners to harness new genetic techniques to better identify sources and risk factors for Campylobacter infection. The project will assist health agencies to include genomics in public health, with findings directly informing government policies and industry practices to minimise disease caused by Campylobacter.
Mechanism design for next generation random access wireless protocols. Australia is well placed to take the lead in replacing carbon-intensive travel by teleconferencing, because of its isolation and geographic dispersion. Because these large distances introduce inevitable delays, it is important that the network itself add as little delay as possible for such real-time services. Our novel and practical resource allocation scheme will enable Australians (including Australian industries and rural ....Mechanism design for next generation random access wireless protocols. Australia is well placed to take the lead in replacing carbon-intensive travel by teleconferencing, because of its isolation and geographic dispersion. Because these large distances introduce inevitable delays, it is important that the network itself add as little delay as possible for such real-time services. Our novel and practical resource allocation scheme will enable Australians (including Australian industries and rural communities) to receive better service at lower cost. This project will put Australia on the international stage as a leading contributor to wireless Internet technology. We will provide training for PhD students and postdoctoral fellows in this important area.Read moreRead less
Biofocussed Prostate Cancer RadioTherapy (BiRT): A Personalised Approach To Delivering The Right Dose To The Right Place
Funder
National Health and Medical Research Council
Funding Amount
$753,565.00
Summary
We propose a new approach to treating prostate cancer with radiotherapy to move from the standard whole prostate treatment to a personalised treatment that varies radiation intensity throughout the prostate. We will mathematically combine features that influence radiotherapy effect from advanced imaging, clinical and biopsy information. This model will map out the radiotherapy dose required at each part of the prostate, to maximise killing of the cancer whilst minimising harm to normal tissue