Environmental Risk Factors For Iron Overload-related Disease In A Cohort Study Of Hereditary Haemochromatosis
Funder
National Health and Medical Research Council
Funding Amount
$152,936.00
Summary
Results published last year from our Melbourne HealthIron study of hereditary haemochromatosis (iron overload disease) show that almost one third of the 50,000 men genetically at risk of iron overload in Australia will develop symptoms of disease including fatigue, arthritis and liver damage. We will use data from the recent follow-up of the Health2020 cohort, of which HealthIron is a sub-study, to determine environmental risk factors for progression to disease in people with iron overload.
Germline Mutations In Mismatch Repair Genes: Prevalence, Risk Of Cancer, And Environmental Modifiers Of Risk.
Funder
National Health and Medical Research Council
Funding Amount
$216,750.00
Summary
Aims: 1. Develop a model that will predict who has a mutation in a group of genes that cause cancer 2. Estimate risk of cancer in people who have a mutation in these genes (carriers) 3. Determine if cancer risk in carriers can be reduced People who inherit a mutation in a group of genes called 'mismatch repair genes' are at increased risk of cancer, particularly cancer of the colon and rectum. If these carriers can be identified they can take preventive measures such as screening to reduce their ....Aims: 1. Develop a model that will predict who has a mutation in a group of genes that cause cancer 2. Estimate risk of cancer in people who have a mutation in these genes (carriers) 3. Determine if cancer risk in carriers can be reduced People who inherit a mutation in a group of genes called 'mismatch repair genes' are at increased risk of cancer, particularly cancer of the colon and rectum. If these carriers can be identified they can take preventive measures such as screening to reduce their risk of cancer and death. We will develop a model using data from the Colon Cancer Family Registry (CFR), the world's largest dataset of carriers and non-carriers which has already recruited and genetically tested over 4,000 families from Australasia, USA and Canada. The model will allow clinicians to predict who is a likely be a carrier based so they can be tested for the mutation. We know the risk of cancer is high in carriers, but we don't have precise estimates. We will use the Colon CFR applying sophisticated statistical methods required to answer this question. This data is critical for genetic counselling so appropriate decisions can be made by the patient and the doctor as to what preventive measures to take. We will also use the Colon CFR data to find out what how the carriers who develop cancer differ from those who stay cancer free using their completed lifestyle questionnaires which includes questions on diet, smoking, alcohol consumption, exercise, aspirin use, and oral contraceptive pill use. We may identify risk factors that carriers can avoid (or take up if they reduce cancer risk) to reduce their risk of cancer.Read moreRead less
Advancing The Assessment Of Environmental Impacts On Human Health
Funder
National Health and Medical Research Council
Funding Amount
$419,180.00
Summary
Key questions and methodology challenges remain in the assessment of environmental impacts on human health. Through the Career Development Fellowship, I will lead a multidisciplinary program of research to further my research aspirations of developing advanced methods in the field of environmental health. The findings will provide epidemiological evidence that would be the basis of policies and guidelines for effective prevention of adverse health impacts from environmental factors.
Deeper and broader life cycle risk assessment - extending the frontier for hybrid methodologies. This project is about combining detailed and global perspectives of environmental health risk from different fields of planning practice. It aims to improve the depth and breadth of the types of information used by government regulators and the community in decisions about the development of capital works.
Special Research Initiatives - Grant ID: SR0354804
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
ARC Research Network on Degraded Environment Assessment and Remediation. There are over 80,000 contaminated sites in Australia and >750,000,000 hectares of land impacted by soil acidity, sodicity, heavy-metals, nutrients and agricultural chemicals. The research network advances assessment, management and remediation of degraded environments (land, water, and air) through collaboration of the research programs developing sustainable solutions. The collective focus is minimising disposal and impac ....ARC Research Network on Degraded Environment Assessment and Remediation. There are over 80,000 contaminated sites in Australia and >750,000,000 hectares of land impacted by soil acidity, sodicity, heavy-metals, nutrients and agricultural chemicals. The research network advances assessment, management and remediation of degraded environments (land, water, and air) through collaboration of the research programs developing sustainable solutions. The collective focus is minimising disposal and impacts of contaminated soil and wastes, and land remediation. By facilitating communication, the network enhances national and international research coordination, interaction with regulators, end-users, industry, and other stakeholders, achievement of critical mass for new initiatives, enhances research training and contributes to a critical National Priority.Read moreRead less
Production, Fate and Transport of Cyanobacterial Toxins in Waterways. Australian waterways are under severe pressure from both large variation in precipitation patterns and various sources of contamination. In particular, the management of algal blooms costs Australians hundreds of millions of dollars a year. Through the use of a unique approach this project will provide the necessary information for a science based decision making strategies to eradicate, as much as possible, algal blooms and ....Production, Fate and Transport of Cyanobacterial Toxins in Waterways. Australian waterways are under severe pressure from both large variation in precipitation patterns and various sources of contamination. In particular, the management of algal blooms costs Australians hundreds of millions of dollars a year. Through the use of a unique approach this project will provide the necessary information for a science based decision making strategies to eradicate, as much as possible, algal blooms and to reduce the risk of severe injuries to the public, livestock and the environment, resulting from contamination waterways by algal toxins. Read moreRead less
Improved monitoring of aquatic pollutants in national water resources. Clean water is predicted to become the world’s most valuable asset during this century, necessitating the improved monitoring of Australia’s limited water resources. Using a new and integrated monitoring approach, this project expects to develop and implement novel passive sampling technologies to monitor a range of water pollutants, specifically toxic ionised organic chemicals of emerging concern. The outcomes of this projec ....Improved monitoring of aquatic pollutants in national water resources. Clean water is predicted to become the world’s most valuable asset during this century, necessitating the improved monitoring of Australia’s limited water resources. Using a new and integrated monitoring approach, this project expects to develop and implement novel passive sampling technologies to monitor a range of water pollutants, specifically toxic ionised organic chemicals of emerging concern. The outcomes of this project will create cost-effective tools to advance the detection of emerging chemicals in drinking, ground, surface and waste waters. The technology will benefit millions of Australians by safeguarding essential water resources.Read moreRead less