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Application Of Protein Microarrays To Develop A Cross-Species Malaria Vaccine
Funder
National Health and Medical Research Council
Funding Amount
$451,821.00
Summary
Malaria remains a significant public health problem worldwide. Five species of malaria parasites infect humans. The ideal vaccine would be effective against all five species. Using a novel protein microarray approach, we will identify Plasmodium proteins that may be excellent targets of a cross-species malaria vaccine. This research will build on Australia's current strengths in biotechnology and will result in significant economic benefits by facilitating the development of a malaria vaccine.
Regulation Of Antiviral And Antiinflammatory Responses By MTNF: Key Role Of Reverse Signaling By Host And Viral TNFR
Funder
National Health and Medical Research Council
Funding Amount
$568,501.00
Summary
New and re-emerging viral infections continue to pose a major problem. We have recently discovered a hitherto unrecognized process that the body uses to regulate its response to infection. Some viruses have evolved to target this process, underscoring its importance. We will study 2 virus models, poxvirus and influenza A, to understand how this process works during infection. We will also examine the potential to exploit this process to block pathology and influence recovery from infection.
Towards A Chlamydia Vaccine For Males: The Key Role Of Mucosal IgA
Funder
National Health and Medical Research Council
Funding Amount
$418,978.00
Summary
Genital Chlamydia infections are the most common sexually transmitted infection in Australia with annual health costs of 90-160 million dollars. Infection rates in 15-29 olds are increasing at 15-20% per year in both females and males. Antibiotics are currently the treatment of choice, however antibiotic resistance is increasing and most infections are asymptomatic and not treated in the absence of screening programs. This project aims to develop a Chlamydia vaccine tailored to protect males .
Real-time Visualisation Of Dendritic Cell Responses During Cutaneous Leishmania Infection
Funder
National Health and Medical Research Council
Funding Amount
$511,294.00
Summary
Leishmaniasis is one of the six major tropical diseases identified by the WHO for intense further study. The disease affects millions of people worldwide demanding the development of improved vaccines. A prerequisite is a better understanding of the basic mechanisms of anti-parasite immunity. This proposal will employ a novel approach, intravital two-photon microscopy, to directly visualise Leishmania parasites and immune cells in the skin in order to decipher anti-Leishmania immunity.
Structural Investigations Of Bacterial Evasion Of IgA Mucosal And Systemic Immunity
Funder
National Health and Medical Research Council
Funding Amount
$488,812.00
Summary
Nose, throat and skin infections are often caused by streptococcal and staphylococcal bacteria, known as Strep Throat and Golden Staph. Infections can be life-threatening in newborns, the elderly or individuals with weak immune systems. These bacteria make proteins bind and inactivate immune proteins. Our research examines the structural basis for bacterial interactions with a key immune system protein (an antibody called IgA) and may lead to new prevention and treatment strategies.