5D Imaging Flow Cytometry for in vivo Quantification of Biological Fluids. Rapid and accurate quantification of live biological fluid properties at sub-cellular and molecular levels forms the bedrock of biofluidic sciences. Majority of the biofluidic devices rely on quantifying biological fluids after its removal from the body in an in vitro Flow Cytometer (FC). FC faces many caveats i.e. biological degradation and small volume etc. In this project, we shall engineer the first in vivo 5D imaging ....5D Imaging Flow Cytometry for in vivo Quantification of Biological Fluids. Rapid and accurate quantification of live biological fluid properties at sub-cellular and molecular levels forms the bedrock of biofluidic sciences. Majority of the biofluidic devices rely on quantifying biological fluids after its removal from the body in an in vitro Flow Cytometer (FC). FC faces many caveats i.e. biological degradation and small volume etc. In this project, we shall engineer the first in vivo 5D imaging flow cytometer (5D IFC) capable of continuous assessment of potentially entire blood volume in a living mice without removing fluid out of the body. The project represents a major advancement beyond any existing flow cytometer and overcome the engineering limits of state-of-art laser scanning imaging devices.Read moreRead less
A multiplex microscope platform to define molecular events in fluid systems. This project aims to develop a novel microscopy platform that will enable the visualisation and quantification of molecular events occurring under fluid shear stress. The project will generate new knowledge in platelet biology that will allow characterisation and prediction of key molecular and morphological changes occurring across a blood thrombus under flowing conditions as found in the blood vessels. These new tools ....A multiplex microscope platform to define molecular events in fluid systems. This project aims to develop a novel microscopy platform that will enable the visualisation and quantification of molecular events occurring under fluid shear stress. The project will generate new knowledge in platelet biology that will allow characterisation and prediction of key molecular and morphological changes occurring across a blood thrombus under flowing conditions as found in the blood vessels. These new tools and the imaging platform will have applications for researchers wishing to visualise small and rapid molecular events in four dimensions (length, width, height and across time) under fluid shear stress, which is applicable across a range of industries. The project expects to deliver the next generation of intravital microscopes that can visualise and quantify events in a challenging flow environment.Read moreRead less
Noise-free Cryogenic Wavefront Sensing. This project aims to optimise the prototype adaptive optics technology for the Giant Magellan Telescope (GMT) by leveraging past investment in adaptive optics instrumentation and shortwave infrared detector systems. This project expects to generate significant improvements in GMT performance, with ten times greater image resolution than the Hubble Space Telescope and current estimates of >90% sky coverage, compared with ~50% coverage for current technology ....Noise-free Cryogenic Wavefront Sensing. This project aims to optimise the prototype adaptive optics technology for the Giant Magellan Telescope (GMT) by leveraging past investment in adaptive optics instrumentation and shortwave infrared detector systems. This project expects to generate significant improvements in GMT performance, with ten times greater image resolution than the Hubble Space Telescope and current estimates of >90% sky coverage, compared with ~50% coverage for current technology. Expected outcomes of this project include the development of a highly trained workforce and continued international collaboration in the field of high-technology sensor systems. This contribution to the GMT will provide significant benefits—it will change the way we view the Universe.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE200100201
Funder
Australian Research Council
Funding Amount
$530,000.00
Summary
A major upgrade to the Australia Telescope Compact Array. This project aims to upgrade the $150m CSIRO Australia Telescope Compact Array ("the telescope"), by replacing the signal processing electronics and doubling the bandwidth. This will significantly enhance the performance of the telescope, enabling more ambitious science by the 450 researchers and students who use it each year. For example, it will enable the telescope to study radio counterparts to Gravitational Wave sources, and it will ....A major upgrade to the Australia Telescope Compact Array. This project aims to upgrade the $150m CSIRO Australia Telescope Compact Array ("the telescope"), by replacing the signal processing electronics and doubling the bandwidth. This will significantly enhance the performance of the telescope, enabling more ambitious science by the 450 researchers and students who use it each year. For example, it will enable the telescope to study radio counterparts to Gravitational Wave sources, and it will enable it to make detailed observations of initial discoveries made with the Australian Square Kilometre Array Pathfinder and other Australian telescopes. In short, it will enable Australian researchers to do more ambitious research, and make more discoveries, across broad areas of astrophysics.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE200100096
Funder
Australian Research Council
Funding Amount
$1,150,000.00
Summary
A next-generation receiver for Radio Astronomy. This project will provide a next-generation radio astronomy receiver to be used on the Parkes radio telescope. This facility will provide a major increase in performance, particularly in sensitivity and survey speed. The science goals are to better understand the ionized and neutral components of the cosmic web, and their evolution, through observations of Fast Radio Bursts and neutral hydrogen. Advances in the understanding of pulsars, molecules, ....A next-generation receiver for Radio Astronomy. This project will provide a next-generation radio astronomy receiver to be used on the Parkes radio telescope. This facility will provide a major increase in performance, particularly in sensitivity and survey speed. The science goals are to better understand the ionized and neutral components of the cosmic web, and their evolution, through observations of Fast Radio Bursts and neutral hydrogen. Advances in the understanding of pulsars, molecules, radio galaxies and cosmic rays will also be achieved with this facility. The technology is based on cryogenic cooling of a large phased array feed. This receiver is a major advance over existing receivers on the Parkes and Australian SKA Pathfinder (ASKAP) telescopes.Read moreRead less
ARC Centre of Excellence for Gravitational Wave Discovery. ARC Centre of Excellence for Gravitational Wave Discovery. The mission of our Centre is to use gravitational waves to investigate the fundamental nature of relativistic gravity, ultra-dense matter, and cosmology. This will generate critical discoveries that cement Australia's leadership role in the gravitational wave mega-science instruments of the 2030s and 2040s. By bringing together a world-class team with broad and complementary expe ....ARC Centre of Excellence for Gravitational Wave Discovery. ARC Centre of Excellence for Gravitational Wave Discovery. The mission of our Centre is to use gravitational waves to investigate the fundamental nature of relativistic gravity, ultra-dense matter, and cosmology. This will generate critical discoveries that cement Australia's leadership role in the gravitational wave mega-science instruments of the 2030s and 2040s. By bringing together a world-class team with broad and complementary expertise we will develop core technologies for future detectors, discover new sources of gravitational waves, probe fundamental physics, and lay the foundations for an Australian gravitational wave observatory. Our discoveries will inspire Australia's youth to pursue high tech careers and position our staff and students to become leaders in both industry and academia.Read moreRead less