Precision-engineered hybrid core-shell materials . This project aims to develop new platform technologies for making nanostructured hybrid core-shell materials with exceptionally high drug loading and programmed release. Building on this research team's recent breakthrough in the precision engineering of core-shell materials, this research will revolutionise current approaches for making drug-loaded polymer and inorganic particles. Significant outcomes will include a novel sequential nanoprecipi ....Precision-engineered hybrid core-shell materials . This project aims to develop new platform technologies for making nanostructured hybrid core-shell materials with exceptionally high drug loading and programmed release. Building on this research team's recent breakthrough in the precision engineering of core-shell materials, this research will revolutionise current approaches for making drug-loaded polymer and inorganic particles. Significant outcomes will include a novel sequential nanoprecipitation platform technology for making drug-core polymer-shell nanoparticles, and a new bio-inspired approach for making hybrid drug-core silica-shell nanocomposites, and new materials for applications in programmed release and delivery systems.Read moreRead less
Engineering improved technology for nanoparticle-based adjuvant manufacture. Over the next decade nanotechnology will redefine vaccines for animal and human health. Nanoparticle adjuvants will boost engineered vaccines that use minimal antigens such as recombinant proteins and synthetic peptides. This project aims to develop a platform technology for making and controlling the properties of inulin nanoparticles by optimising the engineering and manufacturing aspects of inulin nanoparticles to fu ....Engineering improved technology for nanoparticle-based adjuvant manufacture. Over the next decade nanotechnology will redefine vaccines for animal and human health. Nanoparticle adjuvants will boost engineered vaccines that use minimal antigens such as recombinant proteins and synthetic peptides. This project aims to develop a platform technology for making and controlling the properties of inulin nanoparticles by optimising the engineering and manufacturing aspects of inulin nanoparticles to fundamentally understand the relationship between physical-chemical properties and efficacy. Completion of this project aims to produce potent nanoparticle-based adjuvants underpinned by novel manufacturing technology, to ultimately facilitate the development of more effective and protective vaccines for animals and humans.Read moreRead less
Bio-inspired Nanoparticles for Mechano-Regulation of Stem Cell Fate. Mechanical stimulation plays a critical role in regulating stem cell fate. Nanostructure-mediated mechanical cues can precisely stimulate stem cells, but predicting their impact on stem cell differentiation is challenging. This project aims to engineer nanostructures to regulate stem cell fate and gain a fundamental understanding of the mechanical properties that affect cell function. The expected outcomes and benefits of this ....Bio-inspired Nanoparticles for Mechano-Regulation of Stem Cell Fate. Mechanical stimulation plays a critical role in regulating stem cell fate. Nanostructure-mediated mechanical cues can precisely stimulate stem cells, but predicting their impact on stem cell differentiation is challenging. This project aims to engineer nanostructures to regulate stem cell fate and gain a fundamental understanding of the mechanical properties that affect cell function. The expected outcomes and benefits of this project include a new fundamental understanding of the effect of mechanical properties on cell function, novel insights into the regulation of stem cell fate, and the development of a new class of roughness-tunable materials suitable for use in tissue engineering and pharmaceutical applications. Read moreRead less
Platform technologies for multifunctional nanocarrier systems. Smart targeted nanocarriers offer new opportunities for drug delivery. This project aims to develop new platforms for reproducibly producing and screening targeted nanocarriers. The platform technologies developed in this project aim to revolutionise current strategies for designing and evaluating drug delivery systems, and will accelerate the clinical translation of targeted drug delivery. This will include a novel one-step microflu ....Platform technologies for multifunctional nanocarrier systems. Smart targeted nanocarriers offer new opportunities for drug delivery. This project aims to develop new platforms for reproducibly producing and screening targeted nanocarriers. The platform technologies developed in this project aim to revolutionise current strategies for designing and evaluating drug delivery systems, and will accelerate the clinical translation of targeted drug delivery. This will include a novel one-step microfluidic platform technology for reproducibly producing targeted polymer nanocarriers having systematically varied properties, a dual-templating method for making targeted silica nanocapsules and new design of in vivo-mimicking 'Tissue Chips' for screening and evaluating the nanocarriers.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE230100357
Funder
Australian Research Council
Funding Amount
$409,118.00
Summary
Catalyst design for converting carbon dioxide into valuable chemicals. This project aims to use solar energy to convert carbon dioxide, the primary greenhouse gas that drives global climate change, into valuable chemicals via catalytic reduction. This project expects to facilitate the selective production of valuable ethylene from carbon dioxide reduction by developing novel cocatalyst materials derived from metal-oxo cluster molecules. Expected outcomes include fundamental understanding of the ....Catalyst design for converting carbon dioxide into valuable chemicals. This project aims to use solar energy to convert carbon dioxide, the primary greenhouse gas that drives global climate change, into valuable chemicals via catalytic reduction. This project expects to facilitate the selective production of valuable ethylene from carbon dioxide reduction by developing novel cocatalyst materials derived from metal-oxo cluster molecules. Expected outcomes include fundamental understanding of the structure-property relationship in new catalytic systems, and technological breakthroughs in reducing carbon dioxide emissions. The success of this project will bring significant environmental and economic benefits, and position Australia at the frontier of global transition to a low-carbon economy.Read moreRead less
Photoelectrode design for solar driven methane to methanol conversion. This project aims to achieve efficient photoelectrocatalytic partial oxidation of greenhouse gas methane for methanol production with high selectivity. The program will design new semiconductor materials through rational defect engineering and co-catalyst selection to revolutionise methane conversion. The expected outcomes include sustainable processes to convert methane into valuable liquid chemicals like methanol, and compr ....Photoelectrode design for solar driven methane to methanol conversion. This project aims to achieve efficient photoelectrocatalytic partial oxidation of greenhouse gas methane for methanol production with high selectivity. The program will design new semiconductor materials through rational defect engineering and co-catalyst selection to revolutionise methane conversion. The expected outcomes include sustainable processes to convert methane into valuable liquid chemicals like methanol, and comprehensive understanding on functional material design for solar driven catalytic reactions. The significant benefits will include revolutionary methane mitigation technologies and sustainable processes for value-added chemical production, alleviating key environmental and energy challenges facing Australia and the world.Read moreRead less
Nanoarchitectured multifunctional porous superparamagnetic nanoparticles. This project aims to develop a method for the direct detection of biomarkers based on a new class of highly porous superparamagnetic nanoparticles with peroxidase-like activity. The particles will be used as dispersible capture agents for isolating specific targets in biological samples, and electrocatalytic nanozymes for naked-eye evaluation and electrochemical detection. The project is expected to develop simple, low-cos ....Nanoarchitectured multifunctional porous superparamagnetic nanoparticles. This project aims to develop a method for the direct detection of biomarkers based on a new class of highly porous superparamagnetic nanoparticles with peroxidase-like activity. The particles will be used as dispersible capture agents for isolating specific targets in biological samples, and electrocatalytic nanozymes for naked-eye evaluation and electrochemical detection. The project is expected to develop simple, low-cost, portable devices for the analysis of exosomes and exosomal miRNA in biological samples. The future development of this technology into diagnostic devices will improve patient outcomes by enabling earlier disease diagnosis and improved monitoring of treatment.Read moreRead less
Solar-driven thermochemical dissociation of carbon dioxide and water to produce carbon-neutral fuels. The biggest challenge to humanity of the century is to develop enabling clean energy resources to encounter rapidly diminished fossil fuel and accelerated global warming conditions. This project will offer a solution by developing a unique solar-driven thermochemical system capable of cleaving carbon dioxide and water to produce artificial syngas.
Industrial Transformation Research Hubs - Grant ID: IH210100040
Funder
Australian Research Council
Funding Amount
$5,000,000.00
Summary
ARC RESEARCH HUB FOR CONNECTED SENSORS FOR HEALTH. This Hub aims to develop, manufacture and deploy high-tech, cyber-secure, medically-certified IoT sensors to global health markets by integrating disparate Australian capabilities into a productive end-to-end value chain. This Hub expects to position Australia at the forefront of connected health by integrating sensor science with cyber-secure data analytics, regulatory approval and certified manufacturing capabilities. Expected outcomes of this ....ARC RESEARCH HUB FOR CONNECTED SENSORS FOR HEALTH. This Hub aims to develop, manufacture and deploy high-tech, cyber-secure, medically-certified IoT sensors to global health markets by integrating disparate Australian capabilities into a productive end-to-end value chain. This Hub expects to position Australia at the forefront of connected health by integrating sensor science with cyber-secure data analytics, regulatory approval and certified manufacturing capabilities. Expected outcomes of this Hub include advanced manufacturing capacity for connected sensors, strategic partnerships and commercialisation skills to translate sensors research to create economic benefits such as jobs and locally-made products for domestic and export markets, as well as improving the health of Australians.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL190100139
Funder
Australian Research Council
Funding Amount
$3,185,850.00
Summary
New Artificial Leaf for Efficient Solar Fuel Production . The Fellowship aims to develop next-generation materials that harness solar energy to produce valuable fuels and chemicals from water and carbon dioxide, replacing fossil fuels. The program will design new semiconductor materials to revolutionise solar-to-fuel technologies that currently have very low efficiency. The expected outcomes include innovative systems such as wireless artificial leaves that mimic natural photosynthesis for effic ....New Artificial Leaf for Efficient Solar Fuel Production . The Fellowship aims to develop next-generation materials that harness solar energy to produce valuable fuels and chemicals from water and carbon dioxide, replacing fossil fuels. The program will design new semiconductor materials to revolutionise solar-to-fuel technologies that currently have very low efficiency. The expected outcomes include innovative systems such as wireless artificial leaves that mimic natural photosynthesis for efficient hydrocarbon production, carbon dioxide reduction, and water purification. The expected benefits include next-generation solar fuel and chemical generation technologies, and research capabilities to position Australia as a global leader in the transition to a decarbonised economy.Read moreRead less