Microfluidics with core-shell beads: handling liquids like solids. Reducing waste of consumables in chemical reactions promises to solve environmental problems as well as enable novel applications in space. This project aims to establish a revolutionary fluid handling technology that lowers waste in the labs and in satellites. The project deciphers the fundamental physics behind our recent discovery of encapsulating a tiny liquid content in a solid shell, allowing for handling liquid samples lik ....Microfluidics with core-shell beads: handling liquids like solids. Reducing waste of consumables in chemical reactions promises to solve environmental problems as well as enable novel applications in space. This project aims to establish a revolutionary fluid handling technology that lowers waste in the labs and in satellites. The project deciphers the fundamental physics behind our recent discovery of encapsulating a tiny liquid content in a solid shell, allowing for handling liquid samples like solid particles. Examples of the benefit of this project are more precise detection of bacteria on earth and compact reactors in space. The research outcomes are instrumental for promoting a clean environment, good health, and creating new business opportunities, particularly in space industry, for Australians.Read moreRead less
Mitigating Vehicular Crashes into Masonry Buildings . Around 2000 vehicles crash annually into school, home and shop buildings located at close proximity to heavily trafficked roads in Australia and cause significant distress to occupants of building and vehicle. The impacted walls mostly of masonry, suffer severe damage often with vehicle intrusion into the building. Despite this, the intrusion mechanism is not understood and no effective mitigation strategies exist at present. This project wi ....Mitigating Vehicular Crashes into Masonry Buildings . Around 2000 vehicles crash annually into school, home and shop buildings located at close proximity to heavily trafficked roads in Australia and cause significant distress to occupants of building and vehicle. The impacted walls mostly of masonry, suffer severe damage often with vehicle intrusion into the building. Despite this, the intrusion mechanism is not understood and no effective mitigation strategies exist at present. This project will uncover the mechanics of vehicle intrusions through masonry walls and develop novel mitigation strategies using high energy absorbing auxetic composite render and innovative vibration isolation at wall edges. These innovations will lead to new theories that can save lives in the building and vehicle.Read moreRead less
Multifunctional Structural Panels for Next-generation Infrastructure. This project aims to develop a multifunctional prefabricated structural panel for current and future infrastructure applications for both land and offshore environments. Prefabrication enables enhanced product control as well as the ability to rapidly construct whole structures or their components. The panels utilise an inner lightweight foam and fibre-reinforced polymer (FRP) composite core with strong outer panels made from ....Multifunctional Structural Panels for Next-generation Infrastructure. This project aims to develop a multifunctional prefabricated structural panel for current and future infrastructure applications for both land and offshore environments. Prefabrication enables enhanced product control as well as the ability to rapidly construct whole structures or their components. The panels utilise an inner lightweight foam and fibre-reinforced polymer (FRP) composite core with strong outer panels made from FRP sheets and high-strength concrete. The expected outcomes include experimental and numerical validation of the system, that will give designers and asset owners the confidence to adopt this new panel. The panel system presents an upward step change in construction technology and built infrastructure performance.Read moreRead less
Precision-engineered hybrid core-shell materials . This project aims to develop new platform technologies for making nanostructured hybrid core-shell materials with exceptionally high drug loading and programmed release. Building on this research team's recent breakthrough in the precision engineering of core-shell materials, this research will revolutionise current approaches for making drug-loaded polymer and inorganic particles. Significant outcomes will include a novel sequential nanoprecipi ....Precision-engineered hybrid core-shell materials . This project aims to develop new platform technologies for making nanostructured hybrid core-shell materials with exceptionally high drug loading and programmed release. Building on this research team's recent breakthrough in the precision engineering of core-shell materials, this research will revolutionise current approaches for making drug-loaded polymer and inorganic particles. Significant outcomes will include a novel sequential nanoprecipitation platform technology for making drug-core polymer-shell nanoparticles, and a new bio-inspired approach for making hybrid drug-core silica-shell nanocomposites, and new materials for applications in programmed release and delivery systems.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC230100015
Funder
Australian Research Council
Funding Amount
$5,000,000.00
Summary
ARC Training Centre for Whole Life Design of Carbon Neutral Infrastructure. This Centre aims to transform the capability of civil infrastructure stakeholders to design, construct, operate and dispose of infrastructure in a carbon neutral way. By training industry-embedded PhDs and postdocs in the methodology and technology required to design out excess carbon of infrastructure in its whole life, this Centre expects to lead the world in sustainable infrastructure design, enabling a new generation ....ARC Training Centre for Whole Life Design of Carbon Neutral Infrastructure. This Centre aims to transform the capability of civil infrastructure stakeholders to design, construct, operate and dispose of infrastructure in a carbon neutral way. By training industry-embedded PhDs and postdocs in the methodology and technology required to design out excess carbon of infrastructure in its whole life, this Centre expects to lead the world in sustainable infrastructure design, enabling a new generation of infrastructure design in Australia and internationally. Achieving carbon neutral infrastructure in its whole life will bring significant far-reaching benefits, including equipping industry with tools required to meet Australia’s emission reduction targets as well as economic, commercial, environmental, and social gains.Read moreRead less
Mechanical modulation of particle-cell interactions. Mechanical forces play critical roles in many biological processes, but how particle mechanical properties modulate particle-cell interactions remains elusive. This project aims to develop new design principles for engineering nano/micromaterials with tunable mechanical properties for improved cell activation and expansion, and to advance knowledge of the role of particle stiffness in modulating receptor-mediated particle-cell interactions. Ex ....Mechanical modulation of particle-cell interactions. Mechanical forces play critical roles in many biological processes, but how particle mechanical properties modulate particle-cell interactions remains elusive. This project aims to develop new design principles for engineering nano/micromaterials with tunable mechanical properties for improved cell activation and expansion, and to advance knowledge of the role of particle stiffness in modulating receptor-mediated particle-cell interactions. Expected outcomes and benefits include new fundamental understanding of the effect of particle mechanical properties on cell function, new insights into T cell activation and expansion, and new classes of stiffness-tunable fit-for-purpose materials for various applications in cell manufacturing.Read moreRead less
Industrial Transformation Research Hubs - Grant ID: IH150100006
Funder
Australian Research Council
Funding Amount
$5,000,000.00
Summary
ARC Research Hub for Nanoscience-based Construction Material Manufacturing. ARC Research Hub for Nanoscience-based Construction Material Manufacturing. This research hub aims to develop novel construction materials including binders, cement additives, high-performance concrete materials, concrete structural systems, polymer composites, and pavement materials. The multi-disciplinary hub provides a centralised platform to transform the construction materials industry into an advanced manufacturing ....ARC Research Hub for Nanoscience-based Construction Material Manufacturing. ARC Research Hub for Nanoscience-based Construction Material Manufacturing. This research hub aims to develop novel construction materials including binders, cement additives, high-performance concrete materials, concrete structural systems, polymer composites, and pavement materials. The multi-disciplinary hub provides a centralised platform to transform the construction materials industry into an advanced manufacturing sector delivering sustainable and resilient infrastructure assets. The hub intends to develop nanotechnology, cement chemistry, concrete technology and extreme engineering solutions; and to train the next generation of skilled workers, re-positioning Australian industry competitiveness and global market leadership to capture international infrastructure development opportunities.Read moreRead less
Protein biosensors for detecting smoke exposure of grapes. Bush fires and controlled burns that take place in the vicinity of vineyards can lead to grape contamination with tasteless phenolic glucosides. Their hydrolysis during wine making leads to “smoke taint” – an unpleasant medicinal taste that can render wine undrinkable. We will apply a combination of organic synthesis, protein engineering and directed evolution to develop protein-based biosensors of phenolic glucosides. These biosensors w ....Protein biosensors for detecting smoke exposure of grapes. Bush fires and controlled burns that take place in the vicinity of vineyards can lead to grape contamination with tasteless phenolic glucosides. Their hydrolysis during wine making leads to “smoke taint” – an unpleasant medicinal taste that can render wine undrinkable. We will apply a combination of organic synthesis, protein engineering and directed evolution to develop protein-based biosensors of phenolic glucosides. These biosensors will be used to devise a simple portable colorimetric test that can be performed in the vineyard or the winery. The ability to rapidly determine the level of grape contamination with phenolic glucosides would give Australian wine growers and wine makers a powerful tool to mitigate the effects of bushfires.Read moreRead less
Designing Learning Spaces for Diversity, Inclusion and Participation. This project aims to provide evidence-based guidance on how to design and/or modify mainstream schools to make it easier for students with disabilities to participate. It seeks to inform architects, educators, and policy makers about disabled students' spatial requirements and to develop strategies and tools to support the process of co-designing schools with people with lived experience of disability. The outcomes will includ ....Designing Learning Spaces for Diversity, Inclusion and Participation. This project aims to provide evidence-based guidance on how to design and/or modify mainstream schools to make it easier for students with disabilities to participate. It seeks to inform architects, educators, and policy makers about disabled students' spatial requirements and to develop strategies and tools to support the process of co-designing schools with people with lived experience of disability. The outcomes will include an inclusive learning spaces design framework. This is expected to benefit all students' access and meaningful involvement in learning through the development of more inclusive learning spaces. The research is significant because it integrates previously dissociated knowledge from architecture, education and health.Read moreRead less
Industrial Transformation Research Hubs - Grant ID: IH150100028
Funder
Australian Research Council
Funding Amount
$3,708,510.00
Summary
ARC Research Hub for Integrated Device for End-user Analysis at Low-levels. ARC Research Hub for Integrated Device for End-user Analysis at Low-levels. This hub aims to improve detection of biological materials by building a portable device for rapid, time-critical detection of low-abundance molecular and cellular analytes. It is expected that the resulting technologies would be used at medical points of care, ordinary workplaces and centres of activity to test for tiny levels of targeted molecu ....ARC Research Hub for Integrated Device for End-user Analysis at Low-levels. ARC Research Hub for Integrated Device for End-user Analysis at Low-levels. This hub aims to improve detection of biological materials by building a portable device for rapid, time-critical detection of low-abundance molecular and cellular analytes. It is expected that the resulting technologies would be used at medical points of care, ordinary workplaces and centres of activity to test for tiny levels of targeted molecules. The initial focus would be early diagnosis of disease and point-of-care drug testing for humans and animals, but the technology platform could be used to sample food and environmental toxins. The hub expects these disruptive technologies will make Australian biotechnology, diagnostics, veterinary, agribusiness and manufacturing firms globally competitive.Read moreRead less