Bio-inspired Nanoparticles for Mechano-Regulation of Stem Cell Fate. Mechanical stimulation plays a critical role in regulating stem cell fate. Nanostructure-mediated mechanical cues can precisely stimulate stem cells, but predicting their impact on stem cell differentiation is challenging. This project aims to engineer nanostructures to regulate stem cell fate and gain a fundamental understanding of the mechanical properties that affect cell function. The expected outcomes and benefits of this ....Bio-inspired Nanoparticles for Mechano-Regulation of Stem Cell Fate. Mechanical stimulation plays a critical role in regulating stem cell fate. Nanostructure-mediated mechanical cues can precisely stimulate stem cells, but predicting their impact on stem cell differentiation is challenging. This project aims to engineer nanostructures to regulate stem cell fate and gain a fundamental understanding of the mechanical properties that affect cell function. The expected outcomes and benefits of this project include a new fundamental understanding of the effect of mechanical properties on cell function, novel insights into the regulation of stem cell fate, and the development of a new class of roughness-tunable materials suitable for use in tissue engineering and pharmaceutical applications. Read moreRead less
Solar Nano-photocatalytic Disinfection and Mineralization of Treated Wastewater from Sewage Treatment Plants. Reuse of the treated wastewater from sewage treatment plants (STPs) has become significantly important in Australia due to dwindling water resources. The poor quality of the wastewater has limited its use for agriculture and aquaculture. This project aims to develop a solar nano-photocatalytic tertiary wastewater treatment process for disinfection and mineralization of the treated waste ....Solar Nano-photocatalytic Disinfection and Mineralization of Treated Wastewater from Sewage Treatment Plants. Reuse of the treated wastewater from sewage treatment plants (STPs) has become significantly important in Australia due to dwindling water resources. The poor quality of the wastewater has limited its use for agriculture and aquaculture. This project aims to develop a solar nano-photocatalytic tertiary wastewater treatment process for disinfection and mineralization of the treated wastewater from STPs, making the wastewater suitable as a water resource. The newly developed nano-fibre catalysts and photocatalytic technology in the teatm will be used and further developed in this novel process. The research will focus on the water quality objectives in terms of technical reliability, and economic and environmental sustainability.Read moreRead less
Catalysts for hydrogen-free ammonia production by electrochemical method. This project aims to realise the next generation of ammonia production under ambient conditions without hydrogen feedstock. Through a combination of theoretical molecular-level understanding and experimental materials engineering, a range of catalysts will be developed under a materials discovery scheme for electrochemical nitrogen reduction to ammonia. These new catalysts, featuring high activity, efficiency, selectivity, ....Catalysts for hydrogen-free ammonia production by electrochemical method. This project aims to realise the next generation of ammonia production under ambient conditions without hydrogen feedstock. Through a combination of theoretical molecular-level understanding and experimental materials engineering, a range of catalysts will be developed under a materials discovery scheme for electrochemical nitrogen reduction to ammonia. These new catalysts, featuring high activity, efficiency, selectivity, and stability, will facilitate an alternative artificial nitrogen fixation technology powered by renewable energies. This technology will enable the production of green fertilisers and provide renewable energy storage, which are key environmental and energy challenges that Australia and the world currently face.Read moreRead less
Utilisation of dense gas technology for the development of controlled release active pharmaceutical ingredients (API) delivery systems. The aim of this project is to develop an orally administered drug formulation for the treatment of irritable bowel syndrome and other diseases of the colon. Irritable bowel syndrome is a debilitating condition and the cost to society is similar to that of asthma. As such, the project has the potential to have a major impact on society.
Micro Process Plants - Non-Newtonian flow and particle synthesis in confined geometries. Understanding the flow behaviour of well characterised non-Newtonian fluids within microfluidic and nanofluidic devices is of vital importance to development of novel high-value added services, products and devices within Australia's burgeoning biotechnology, environmental technology, communications and information technology industries. The outcomes of this project will provide new 'systematic' design stand ....Micro Process Plants - Non-Newtonian flow and particle synthesis in confined geometries. Understanding the flow behaviour of well characterised non-Newtonian fluids within microfluidic and nanofluidic devices is of vital importance to development of novel high-value added services, products and devices within Australia's burgeoning biotechnology, environmental technology, communications and information technology industries. The outcomes of this project will provide new 'systematic' design standards for microdevice manufacture for these industries, ultimately leading to the creation of new, exciting avenues for tailoring novel biotechnology and 'point-of-care' products for Australia.Read moreRead less
Photonic Crystal Enhanced Wavelength Selective, Multi-Colour Quantum Dot Infrared Photodetectors. Photonic crystal enhanced quantum dot infrared photodetectors are a new generation of detectors developed from integrating nanotechnology with material science and optics. This would not only enhance the detector performance but the structure will now detect a narrow band around the desired wavelength with multi-colour detectivity. The technology developed in this project is anticipated to attract i ....Photonic Crystal Enhanced Wavelength Selective, Multi-Colour Quantum Dot Infrared Photodetectors. Photonic crystal enhanced quantum dot infrared photodetectors are a new generation of detectors developed from integrating nanotechnology with material science and optics. This would not only enhance the detector performance but the structure will now detect a narrow band around the desired wavelength with multi-colour detectivity. The technology developed in this project is anticipated to attract interest from the industries and government agencies. It will be pervasive for use at home, in the manufacturing and mining industry, environmental and pollution monitoring, defence and national security. Applications include spectral imaging, remote sensing, environmental/pollution monitoring, toxic gas and bio-hazardous material detection.Read moreRead less
Using solar photocatalytic oxidation processes to treat organic pollutants in wastewater. The proposal is to use physical-chemical and solar engineering approaches to increase the efficiency of solar photons in the photocatalytic oxidation process applied to the detoxification of organic pollutants in wastewater. New photocatalyists and the effects of photocatalysts's superficial characteristics on the treatment perfomance will be studied. A specific structure for a solar collector for the proce ....Using solar photocatalytic oxidation processes to treat organic pollutants in wastewater. The proposal is to use physical-chemical and solar engineering approaches to increase the efficiency of solar photons in the photocatalytic oxidation process applied to the detoxification of organic pollutants in wastewater. New photocatalyists and the effects of photocatalysts's superficial characteristics on the treatment perfomance will be studied. A specific structure for a solar collector for the process will be developed. A more efficient way to use solar photons in the process and a better conceptual design of solar collector will be two main outcomes expected from the project.Read moreRead less
Capturing full-spectrum of solar energy using TiO2 ordered suprastructures. The project aims to develop a titanium dioxide (TiO2) semiconductor that can use full-spectrum solar energy. Solar-driven photocatalytic processes have important applications in water decontamination and energy production. Their effectiveness is dictated by the semiconductor’s absorbance and conversion of photoenergy to chemical energy. Being inexpensive, chemically and mechanically robust, TiO2 is the most promising mat ....Capturing full-spectrum of solar energy using TiO2 ordered suprastructures. The project aims to develop a titanium dioxide (TiO2) semiconductor that can use full-spectrum solar energy. Solar-driven photocatalytic processes have important applications in water decontamination and energy production. Their effectiveness is dictated by the semiconductor’s absorbance and conversion of photoenergy to chemical energy. Being inexpensive, chemically and mechanically robust, TiO2 is the most promising material for the semiconductor. However, unmodified TiO2 only absorbs ultraviolet light (5 per cent of solar energy). With current progress made in visible absorbance, this project aims to significantly improve TiO2’s absorbance in near infrared by doping with upconversion lanthanides and rendering colloidal crystal suprastructures that can trap light.Read moreRead less
Exploring the bio-nano interface in plants to enhance crop growth. This project aims to improve the delivery of nutrients and therapeutics to plants by understanding their interactions with nanomaterials. This will create new knowledge on the impact of air, water, and soilborne nanomaterials utilizing cutting-edge bio-nano characterization techniques, innovative lab testing, and high-throughput nanoparticle coating and screening. Expected outcomes of the project include 1) an understanding into ....Exploring the bio-nano interface in plants to enhance crop growth. This project aims to improve the delivery of nutrients and therapeutics to plants by understanding their interactions with nanomaterials. This will create new knowledge on the impact of air, water, and soilborne nanomaterials utilizing cutting-edge bio-nano characterization techniques, innovative lab testing, and high-throughput nanoparticle coating and screening. Expected outcomes of the project include 1) an understanding into how nanomaterial coating technologies impact nanomaterial properties, which will 2) shed light on how nanomaterials interact with plants, which leads to 3) breakthroughs in using nanomaterials to deliver nutrients, fertilizers, and pesticides to boost crop yields and productivity in Australian agriculture.Read moreRead less
Micro/nano smart surfaces to unlock the potential of multipotent stem cells. This project aims to determine the interplay of micro/nanostructures on stem cell mechanotransduction and to control the cellular environment. It is expected that this will expand our knowledge on how to control stem cell fate. Expected outcomes are novel scalable technologies for micro/nanostructures and smart surfaces, controlled stem-cell expansion and differentiation, and the creation of a library of protein express ....Micro/nano smart surfaces to unlock the potential of multipotent stem cells. This project aims to determine the interplay of micro/nanostructures on stem cell mechanotransduction and to control the cellular environment. It is expected that this will expand our knowledge on how to control stem cell fate. Expected outcomes are novel scalable technologies for micro/nanostructures and smart surfaces, controlled stem-cell expansion and differentiation, and the creation of a library of protein expression based on the cell interactions. These outcomes will provide critical information required for the future development of instructive biomaterials to drive stem cell expansion and tissue-regeneration. Those materials should benefit the future development of efficient and cost-effective regenerative medicine solutions.Read moreRead less