Engineering improved technology for nanoparticle-based adjuvant manufacture. Over the next decade nanotechnology will redefine vaccines for animal and human health. Nanoparticle adjuvants will boost engineered vaccines that use minimal antigens such as recombinant proteins and synthetic peptides. This project aims to develop a platform technology for making and controlling the properties of inulin nanoparticles by optimising the engineering and manufacturing aspects of inulin nanoparticles to fu ....Engineering improved technology for nanoparticle-based adjuvant manufacture. Over the next decade nanotechnology will redefine vaccines for animal and human health. Nanoparticle adjuvants will boost engineered vaccines that use minimal antigens such as recombinant proteins and synthetic peptides. This project aims to develop a platform technology for making and controlling the properties of inulin nanoparticles by optimising the engineering and manufacturing aspects of inulin nanoparticles to fundamentally understand the relationship between physical-chemical properties and efficacy. Completion of this project aims to produce potent nanoparticle-based adjuvants underpinned by novel manufacturing technology, to ultimately facilitate the development of more effective and protective vaccines for animals and humans.Read moreRead less
Precision-engineered hybrid core-shell materials . This project aims to develop new platform technologies for making nanostructured hybrid core-shell materials with exceptionally high drug loading and programmed release. Building on this research team's recent breakthrough in the precision engineering of core-shell materials, this research will revolutionise current approaches for making drug-loaded polymer and inorganic particles. Significant outcomes will include a novel sequential nanoprecipi ....Precision-engineered hybrid core-shell materials . This project aims to develop new platform technologies for making nanostructured hybrid core-shell materials with exceptionally high drug loading and programmed release. Building on this research team's recent breakthrough in the precision engineering of core-shell materials, this research will revolutionise current approaches for making drug-loaded polymer and inorganic particles. Significant outcomes will include a novel sequential nanoprecipitation platform technology for making drug-core polymer-shell nanoparticles, and a new bio-inspired approach for making hybrid drug-core silica-shell nanocomposites, and new materials for applications in programmed release and delivery systems.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE170100174
Funder
Australian Research Council
Funding Amount
$193,000.00
Summary
Acoustic levitation facility for high pressure multiphase systems research. This project aims to create a specialised acoustic levitation facility that delivers precise control of a suspended particle/droplet/bubble within a high pressure continuous phase, and simultaneous measurement of multiple bulk and interfacial properties. Acoustic levitation enables container-less experiments, offering opportunities for applied engineering and fundamental science. This acoustic levitation system will be i ....Acoustic levitation facility for high pressure multiphase systems research. This project aims to create a specialised acoustic levitation facility that delivers precise control of a suspended particle/droplet/bubble within a high pressure continuous phase, and simultaneous measurement of multiple bulk and interfacial properties. Acoustic levitation enables container-less experiments, offering opportunities for applied engineering and fundamental science. This acoustic levitation system will be integrated with a specialised Raman imaging microscope to study crystallisation, mass transfer and molecular exchange, in application areas including energy transport, carbon capture and storage, and protein nucleation. This project is expected to open new avenues in engineering, chemistry and physics.Read moreRead less
Developing novel two-dimensional hybrid nanostructures for renewable energy. This project aims to develop novel two-dimensional (2D) hybrid nanostructures with new physical and chemical properties. This innovation intends to address the critical challenges of control functionalisation of 2D hybrid nanostructures: essential to understanding the potential of nanomaterials in key applications of energy generation. Expected outcomes include scalable technology to produce functional 2D nanomaterials ....Developing novel two-dimensional hybrid nanostructures for renewable energy. This project aims to develop novel two-dimensional (2D) hybrid nanostructures with new physical and chemical properties. This innovation intends to address the critical challenges of control functionalisation of 2D hybrid nanostructures: essential to understanding the potential of nanomaterials in key applications of energy generation. Expected outcomes include scalable technology to produce functional 2D nanomaterials and hybrid nanostructures to accelerate research to advanced materials and frontier material manufacturing technologies. This project will provide significant social and economic benefits to Australia in the growth of sectors in advanced materials, energy generation, and advanced manufacturing.Read moreRead less
The true potential and limitations of fibres. This project aims to understand the fibre spinning process of nanomaterials to identify their true potential and limitations in wearable applications. The project is expected to lead to multifunctional materials that allow design and production of smart functional fibres and textiles that store and convert energy and sense, monitor and respond to human activities and external environments. The project outcomes are expected to accelerate the transform ....The true potential and limitations of fibres. This project aims to understand the fibre spinning process of nanomaterials to identify their true potential and limitations in wearable applications. The project is expected to lead to multifunctional materials that allow design and production of smart functional fibres and textiles that store and convert energy and sense, monitor and respond to human activities and external environments. The project outcomes are expected to accelerate the transformation of the fibre industry, which will have far reaching implications across research disciplines and sectors critical to technology, health, social, and economic future.Read moreRead less
Nanoarchitectured multifunctional porous superparamagnetic nanoparticles. This project aims to develop a method for the direct detection of biomarkers based on a new class of highly porous superparamagnetic nanoparticles with peroxidase-like activity. The particles will be used as dispersible capture agents for isolating specific targets in biological samples, and electrocatalytic nanozymes for naked-eye evaluation and electrochemical detection. The project is expected to develop simple, low-cos ....Nanoarchitectured multifunctional porous superparamagnetic nanoparticles. This project aims to develop a method for the direct detection of biomarkers based on a new class of highly porous superparamagnetic nanoparticles with peroxidase-like activity. The particles will be used as dispersible capture agents for isolating specific targets in biological samples, and electrocatalytic nanozymes for naked-eye evaluation and electrochemical detection. The project is expected to develop simple, low-cost, portable devices for the analysis of exosomes and exosomal miRNA in biological samples. The future development of this technology into diagnostic devices will improve patient outcomes by enabling earlier disease diagnosis and improved monitoring of treatment.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE160100796
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Superior Adsorption Capability of Nanosheets for Surface Enhanced Raman. This project aims to create nanotechnologies to sense traces of chemical and biological molecules. Surface adsorption is vital to many scientific and industrial fields, but the intrinsic adsorption property of two-dimensional nanomaterials is largely unknown. This project aims to examine the adsorption capability of nanosheets, such as boron nitride, and understand the thickness effect on their adsorption at the molecular s ....Superior Adsorption Capability of Nanosheets for Surface Enhanced Raman. This project aims to create nanotechnologies to sense traces of chemical and biological molecules. Surface adsorption is vital to many scientific and industrial fields, but the intrinsic adsorption property of two-dimensional nanomaterials is largely unknown. This project aims to examine the adsorption capability of nanosheets, such as boron nitride, and understand the thickness effect on their adsorption at the molecular scale. It also aims to demonstrate the use of these nanosheets as substrates in surface-enhanced Raman spectroscopy. Their adsorption capability and other unique properties could improve the sensitivity, efficiency and affordability of this technique in chemical and biological sensing for applications such as air, water and food safety; and pharmaceutical and cosmetic industries.Read moreRead less
Platform technologies for multifunctional nanocarrier systems. Smart targeted nanocarriers offer new opportunities for drug delivery. This project aims to develop new platforms for reproducibly producing and screening targeted nanocarriers. The platform technologies developed in this project aim to revolutionise current strategies for designing and evaluating drug delivery systems, and will accelerate the clinical translation of targeted drug delivery. This will include a novel one-step microflu ....Platform technologies for multifunctional nanocarrier systems. Smart targeted nanocarriers offer new opportunities for drug delivery. This project aims to develop new platforms for reproducibly producing and screening targeted nanocarriers. The platform technologies developed in this project aim to revolutionise current strategies for designing and evaluating drug delivery systems, and will accelerate the clinical translation of targeted drug delivery. This will include a novel one-step microfluidic platform technology for reproducibly producing targeted polymer nanocarriers having systematically varied properties, a dual-templating method for making targeted silica nanocapsules and new design of in vivo-mimicking 'Tissue Chips' for screening and evaluating the nanocarriers.Read moreRead less
The effect of structure and size on the mechanical behaviour of III-V semiconductor nanowires. The project aims to apply in-situ deformation transmission electron microscopy to investigate the mechanical behaviour of compound semiconductor nanowires and the effect of structure and geometry on the behaviour. The results will uncover the fundamental mechanical properties of nanowires and will guide the design of nanowire-based devices.
Discovery Early Career Researcher Award - Grant ID: DE160100715
Funder
Australian Research Council
Funding Amount
$330,000.00
Summary
Tunable plasmonics in ultra-doped transition metal oxides and chalcogenides. The project is designed to explore new classes of plasmonic materials based on low-dimensional transition metal oxide and chalcogenide nanostructures. These crystals, with stratified structures and high surface affinities to charged particles, present a new frontier in plasmonics by allowing reversible stimuli induced doping and defect embedding. The project plans to focus on achieving tunable plasmonic properties acros ....Tunable plasmonics in ultra-doped transition metal oxides and chalcogenides. The project is designed to explore new classes of plasmonic materials based on low-dimensional transition metal oxide and chalcogenide nanostructures. These crystals, with stratified structures and high surface affinities to charged particles, present a new frontier in plasmonics by allowing reversible stimuli induced doping and defect embedding. The project plans to focus on achieving tunable plasmonic properties across a broad spectrum from ultraviolet to infrared light. Targets are systems with low propagation losses or ultra-sensitivity towards environmental changes. The anticipated outcomes will serve as a base to establish the next generation plasmonic communication and sensing systems with active on-chip controllability, which could be used as the base of future telecommunications, energy harvesting and sensing systems.Read moreRead less