A multiplex microscope platform to define molecular events in fluid systems. This project aims to develop a novel microscopy platform that will enable the visualisation and quantification of molecular events occurring under fluid shear stress. The project will generate new knowledge in platelet biology that will allow characterisation and prediction of key molecular and morphological changes occurring across a blood thrombus under flowing conditions as found in the blood vessels. These new tools ....A multiplex microscope platform to define molecular events in fluid systems. This project aims to develop a novel microscopy platform that will enable the visualisation and quantification of molecular events occurring under fluid shear stress. The project will generate new knowledge in platelet biology that will allow characterisation and prediction of key molecular and morphological changes occurring across a blood thrombus under flowing conditions as found in the blood vessels. These new tools and the imaging platform will have applications for researchers wishing to visualise small and rapid molecular events in four dimensions (length, width, height and across time) under fluid shear stress, which is applicable across a range of industries. The project expects to deliver the next generation of intravital microscopes that can visualise and quantify events in a challenging flow environment.Read moreRead less
Industrial Transformation Research Hubs - Grant ID: IH190100009
Funder
Australian Research Council
Funding Amount
$3,317,500.00
Summary
ARC Research Hub for Microrecycling of battery and consumer wastes . This project aims to transform Australia’s waste and resource recovery industry by equipping it with scientifically developed advanced manufacturing capability, focusing on small-scale processing of materials produced from battery and consumer wastes which would otherwise mostly end up in landfill. The project will deliver new knowledge in high-temperature reactions of waste and selective synthesis techniques to transform waste ....ARC Research Hub for Microrecycling of battery and consumer wastes . This project aims to transform Australia’s waste and resource recovery industry by equipping it with scientifically developed advanced manufacturing capability, focusing on small-scale processing of materials produced from battery and consumer wastes which would otherwise mostly end up in landfill. The project will deliver new knowledge in high-temperature reactions of waste and selective synthesis techniques to transform waste into valuable materials and products, including metallic alloys, oxides and carbon. Expected outcomes include industry adoption of commercially viable technology and processes where low value or complex waste is reformed into higher value materials, creating jobs and significant environmental and social benefits.Read moreRead less
5D Imaging Flow Cytometry for in vivo Quantification of Biological Fluids. Rapid and accurate quantification of live biological fluid properties at sub-cellular and molecular levels forms the bedrock of biofluidic sciences. Majority of the biofluidic devices rely on quantifying biological fluids after its removal from the body in an in vitro Flow Cytometer (FC). FC faces many caveats i.e. biological degradation and small volume etc. In this project, we shall engineer the first in vivo 5D imaging ....5D Imaging Flow Cytometry for in vivo Quantification of Biological Fluids. Rapid and accurate quantification of live biological fluid properties at sub-cellular and molecular levels forms the bedrock of biofluidic sciences. Majority of the biofluidic devices rely on quantifying biological fluids after its removal from the body in an in vitro Flow Cytometer (FC). FC faces many caveats i.e. biological degradation and small volume etc. In this project, we shall engineer the first in vivo 5D imaging flow cytometer (5D IFC) capable of continuous assessment of potentially entire blood volume in a living mice without removing fluid out of the body. The project represents a major advancement beyond any existing flow cytometer and overcome the engineering limits of state-of-art laser scanning imaging devices.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE210100015
Funder
Australian Research Council
Funding Amount
$1,680,000.00
Summary
The Cherenkov Telescope Array - From Production towards Operation. The Cherenkov Telescope Array is a transformational facility in very-high-energy gamma-ray astronomy. It will be 10 times more sensitive than current instruments and will revolutionise many topics in high energy astrophysics, and in astro-particle physics such as dark matter. Over 1000 scientists from over 30 countries are involved and the first telescopes on the southern hemisphere site in Chile will be installed from about 2021 ....The Cherenkov Telescope Array - From Production towards Operation. The Cherenkov Telescope Array is a transformational facility in very-high-energy gamma-ray astronomy. It will be 10 times more sensitive than current instruments and will revolutionise many topics in high energy astrophysics, and in astro-particle physics such as dark matter. Over 1000 scientists from over 30 countries are involved and the first telescopes on the southern hemisphere site in Chile will be installed from about 2021. This project will ensure Australia's contribution to complete the facility, leading into its operations phase (starting in 2027). It will also fund unique optical astronomy hardware that will enable Australian scientific leadership in supporting some of the Cherenkov Telescope Array's Key Science Projects.
Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE170100104
Funder
Australian Research Council
Funding Amount
$1,390,000.00
Summary
The Cherenkov Telescope Array - Production phase. This project aims to ensure Australia’s contribution to the five-year production phase of the Cherenkov Telescope Array (CTA), a very high energy gamma-ray astronomy instrument that is expected to transform both high energy astrophysics and astro-particle physics. Gamma-ray astronomy probes extreme processes in the Universe such as exploding stars, black holes, and mysterious dark matter. The project will maintain Australian access to all data an ....The Cherenkov Telescope Array - Production phase. This project aims to ensure Australia’s contribution to the five-year production phase of the Cherenkov Telescope Array (CTA), a very high energy gamma-ray astronomy instrument that is expected to transform both high energy astrophysics and astro-particle physics. Gamma-ray astronomy probes extreme processes in the Universe such as exploding stars, black holes, and mysterious dark matter. The project will maintain Australian access to all data and key science programmes of the CTA. Australian astronomers will be able to directly influence the major astrophysics goals of CTA, and link in with Australia's flagship astronomical infrastructure. This is expected to benefit astrophysics, big data processing, electronics, atmospheric physics and optics.Read moreRead less
Making hydrogen storage work for the new hydrogen economy. This project aims to develop an innovative Liquid Organic Hydrogen Storage technology and prove its energy industry potential. This project expects to expand and validate the performance, safety and scale-up potential of this new technology in an industrial context to promote the development of the hydrogen economy. Expected outcomes include providing practical, efficient, large-scale storage technology for use in intermittent renewable ....Making hydrogen storage work for the new hydrogen economy. This project aims to develop an innovative Liquid Organic Hydrogen Storage technology and prove its energy industry potential. This project expects to expand and validate the performance, safety and scale-up potential of this new technology in an industrial context to promote the development of the hydrogen economy. Expected outcomes include providing practical, efficient, large-scale storage technology for use in intermittent renewable energy storage and hydrogen vehicle refuelling, and addressing legal/regulatory implementation issues. This should provide significant benefits in cultivating the emerging hydrogen energy industry, strengthening industrial competitiveness, enhancing Australia’s fuel security and protecting the environment.Read moreRead less
Integrin Activation by Fluid Flow Disturbance: Mechanobiology Approaches. Understanding how cells can sense and respond to mechanical environment such as dynamic blood flow represents a fundamental question in the emerging field of mechanobiology. This project develops new biomechanical engineering approaches to determine the critical interrelationships among fluid flow disturbance, platelet clotting and the mechano-sensitive signal transduction mechanisms of integrin receptor – the most importa ....Integrin Activation by Fluid Flow Disturbance: Mechanobiology Approaches. Understanding how cells can sense and respond to mechanical environment such as dynamic blood flow represents a fundamental question in the emerging field of mechanobiology. This project develops new biomechanical engineering approaches to determine the critical interrelationships among fluid flow disturbance, platelet clotting and the mechano-sensitive signal transduction mechanisms of integrin receptor – the most important mechano-sensor implicated in cell adhesion, migration, growth and survival. Specifically, it integrates nationally unique cutting-edge techniques including single-molecule force probe, microparticle image velocimetry, microfluidics and molecular dynamics simulation, super resolution and 3D volumetric imaging modalities.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC170100032
Funder
Australian Research Council
Funding Amount
$4,272,072.00
Summary
ARC Training Centre in Fire Retardant Materials and Safety Technologies. The ARC Training Centre in Fire Retardant Materials and Safety Technologies aims to train a cohort of industry-focused researchers to improve the fire safety of lightweight materials and structures and fire protection systems. The Training Centre expects to create knowledge on novel green and durable fire retardant materials, advanced fire models for urban and built environment, fire suppression technologies, and new flamma ....ARC Training Centre in Fire Retardant Materials and Safety Technologies. The ARC Training Centre in Fire Retardant Materials and Safety Technologies aims to train a cohort of industry-focused researchers to improve the fire safety of lightweight materials and structures and fire protection systems. The Training Centre expects to create knowledge on novel green and durable fire retardant materials, advanced fire models for urban and built environment, fire suppression technologies, and new flammability tests for compliance with fire safety regulatory standards. An expected outcome of this Training Centre is to accelerate the transformation of Australia’s industries in fire retardant materials, products and engineering services.Read moreRead less