Risk And Prognostic Factors For Breast Cancer Of Different Immunohistochemical Subtypes
Funder
National Health and Medical Research Council
Funding Amount
$294,461.00
Summary
Breast cancer is a heterogeneous disease. Gene expression analysis has identified a number of subtypes that are different with respect to pathology, prognosis, and response to treatment. Building on an existing cohort study, we aim to identify risk and prognostic factors for molecular subtypes of breast cancer.
Allergies And Chronic Respiratory Diseases: Causes, Biological Pathways And Interventions
Funder
National Health and Medical Research Council
Funding Amount
$420,872.00
Summary
Allergies and chronic respiratory diseases are major causes of illness and death in Australia. Worryingly there are still many gaps in knowledge on how best to prevent and manage these diseases. The proposed program will investigate these questions and provide evidence to guide health policy and clinical management. As this program is built on state-of the-art methods and technology, these original Australian findings will be of great importance internationally.
The Epidemiology Of Staphylococcus Aureus And Antibiotic Resistance In Community-acquired Infections
Funder
National Health and Medical Research Council
Funding Amount
$1,267,784.00
Summary
Staphylococcus aureus infections range from boils to life-threatening diseases and are increasingly resistant to antibiotics and difficult to treat. This study follows patients with community-acquired S. aureus infections, and close contacts, for 24 months to see if they carry S. aureus (nose swabs) or develop infection. Our data on risk factors for colonisation and infection will help doctors decide whether to trace and treat contacts of patients to protect households from further infection.
Follow Up Of The 1985 Australian Schools Health And Fitness Survey Cohort
Funder
National Health and Medical Research Council
Funding Amount
$2,309,456.00
Summary
This study provides a unique opportunity to follow up a cohort of children on which an extensive range of physical and lifestyle measures were made in 1985. This study has the capacity to find out whether childhood lifestyle and physical measures are related to the risk of heart disease, diabetes and other common health problems in adulthood.
Cerebral Palsy In Victoria: A Population-based Study
Funder
National Health and Medical Research Council
Funding Amount
$107,990.00
Summary
This research project is broad in its exploration of cerebral palsy in Victoria. It will contribute to the global pool of knowledge by addressing a number of unanswered questions, such as whether the overall rates of cerebral palsy are changing over time, an important indicator of the effect of changes in medical management strategies for pregnancy and newborns. Recognition of patterns of brain abnormalities and other risk factors play an important role in the identification of causal pathways.
The Relationship Between Environmental Exposures And The Development Of Acute Lymphoblastic Leukaemia In Children
Funder
National Health and Medical Research Council
Funding Amount
$88,141.00
Summary
Leukaemia is the most common childhood cancer and is potentially preventable. Little is known about the causes, although it is likely that both genetic and environmental factors play a role. The early age at diagnosis suggests that exposures before birth or in early childhood, may be involved in its development. This study will investigate whether non-occupational environmental exposures in these key time periods increase the risk of disease and thus may help to prevent the disease.
Metabolic And Hormonal Pathways In Gynecological Cancer - Epidemiological Studies Of Risk And Survival
Funder
National Health and Medical Research Council
Funding Amount
$288,275.00
Summary
Metabolic and hormonal factors probably play a role in a womans chance of developing and surviving gynecological cancer, but the exact mechanisms are unclear. This project will use questionnaire information, blood and tumour samples of over 5,000 Australian women to examine the mechanisms leading to cancer development and survival among women with uterine and ovarian cancer, the two commonest female reproductive cancers. Results will help plan primary prevention strategies and care.
David Whiteman is a medical epidemiologist with a special interest in the causes, diagnosis, prevention and treatment of cancer. His work has focussed on melanoma and skin cancer, and more recently, on cancers of the upper gastro-intestinal tract.
Genetic And Environmental Epidemiology Of Early-onset Melanoma In The Australian Melanoma Family Study
Funder
National Health and Medical Research Council
Funding Amount
$412,210.00
Summary
This project will investigate the genetic and environmental causes of melanoma, especially melanoma developing under the age of 40 in Australian families. This project will help to identify which people are at greatest risk of developing melanoma, by identifying the genes involved in melanoma development and the contribution of environmental and lifestyle factors to the disease. We will also determine how much hereditary factors contribute to melanoma risk.