Structural Studies Of Thyroid Peroxidase, An Autoantigen In Autoimmune Thyroid Disease
Funder
National Health and Medical Research Council
Funding Amount
$386,423.00
Summary
This proposal is aimed at determining the three dimensional structure of Thyroid Peroxidase, a protein found in the human thyroid gland that is important in the production of the hormone thyroxine. Thyroxine is involved in controlling the rate of metabolic processes in the body and influencing physical development.
The Function Of The Natural Antisense Ghrelin Receptor Gene (GHSROS) In Cancer
Funder
National Health and Medical Research Council
Funding Amount
$493,750.00
Summary
Lung cancer is the most common cause of cancer deaths in men and women in the world and the incidence in Australia is rising with our aging population. Survival rates for lung cancer are very poor. We have discovered a new gene that is produced by lung cancer cells and may contribute to the aggressive nature of this disease. We will investigate this gene to determine if it could be a useful target for new therapies for lung cancer and it determine its utility as a biomarker for the severity of t ....Lung cancer is the most common cause of cancer deaths in men and women in the world and the incidence in Australia is rising with our aging population. Survival rates for lung cancer are very poor. We have discovered a new gene that is produced by lung cancer cells and may contribute to the aggressive nature of this disease. We will investigate this gene to determine if it could be a useful target for new therapies for lung cancer and it determine its utility as a biomarker for the severity of the disease.Read moreRead less
Open-label Randomised Trial Of Tolvaptan Versus Fluid Restriction In Hospitalised Patients With Moderate-severe Hyponatraemia
Funder
National Health and Medical Research Council
Funding Amount
$132,743.00
Summary
Low blood sodium level, known as hyponatraemia, is the most common electrolyte problem. It occurs in 15% of hospital patients, and can cause confusion, seizure and fatal brain swelling. Standard treatment for hyponatraemia is limiting oral fluid, but this is slow and not always effective. The drug tolvaptan works in mild hyponatraemia, but hasn't been formally tested in severe cases. We will compare benefits and risks of tolvaptan versus fluid restriction in patients with severe hyponatremia.
A Novel Approach To Streamlining The Diagnosis Of Primary Aldosteronism
Funder
National Health and Medical Research Council
Funding Amount
$269,463.00
Summary
This study will assess a new clinical test used to diagnose a potentially curable form of high blood pressure called primary aldosteronism (PA). If successful, the test will greatly streamline and simplify the diagnosis of this condition, with the potential for enormous cost savings and a markedly increased rate of diagnosis of patients with PA who can then benefit from optimal treatment and improved quality of life.
This research aims to advance my novel discoveries of mechanisms through which hormones and enzymes control and coordinate optimal female fertility. The findings are being applied to novel technologies in reproductive medicine. This work further aims to characterize mechanisms of growth and metastasis in reproductive organ cancers. New diagnostics and therapeutics for patients with metastatic reproductive cancers are arising from this research.