Improved Enamel Remineralisation Using A Novel Biomimetic System
Funder
National Health and Medical Research Council
Funding Amount
$746,581.00
Summary
Tooth decay remains a major public health problem. The project will involve the testing of the system to remineralize (repair) early stages of decay. The project also involves the detailed characterization of the molecular interactions of the components of a system. It is anticipated that this project will result in the development of a system with substantially superior properties for the non-invasive treatment (repair) of early tooth decay.
Enamel Remineralisation And Prebiosis By A Novel Biomimetic System
Funder
National Health and Medical Research Council
Funding Amount
$800,585.00
Summary
Tooth decay and erosion involve loss of tooth mineral and are major public health problems.The project will involve the testing of a prototype professional product “Tooth Mousse Professional” to repair early stages of mineral loss. It is anticipated that this project will result in the development of a system with substantially superior properties for the non-invasive treatment of early tooth decay and erosion. The system will also encourage the growth of beneficial bacteria in the mouth.
The Relationship Between Genes, Environment And Oral Disease In Childhood - A Study Of Twins
Funder
National Health and Medical Research Council
Funding Amount
$88,766.00
Summary
Half of Australia's children suffer tooth decay, placing them at risk of toothache, infection and hospitalisation, as well as a host of other problems like sleeping, eating and concentrating. Current preventive strategies are failing, due to an incomplete understanding of the causes of decay. This study of twins, who have been followed since pregnancy, will help to explain the role of genetics as well as other factors such as maternal and early childhood illness in dental disease.
Integrating Basic, Clinical And Applied Research To Prevent Tooth Decay
Funder
National Health and Medical Research Council
Funding Amount
$313,677.00
Summary
There is nothing quite like the searing intensity of dental pain to remind us of the value of healthy teeth. When our children are afflicted the effects can be devastating for families and clinicians. Sadly, many Australian children must bear this pain due to a widespread developmental condition called Molar Hypomineralisation (MH). The proposed translational research project seeks to reduce the pain associated with MH by providing new treatment approaches and ultimately prevention.
Therapeutic Targeting Of The Hedgehog Signaling Pathway In Premalignant Lesions Of The Breast.
Funder
National Health and Medical Research Council
Funding Amount
$115,980.00
Summary
Breast screening has been successful in reducing deaths from breast cancer. Unfortunately it also detects increasing numbers of precancerous changes. Treatment of these changes is often aggressive, using surgery and radiotherapy. However we are unable to predict exactly which of the changes we need to treat. We aim to better understand the changes involved in this progression and try to block them using new drugs.
What Factors Affect Lesion Distribution In Multiple Sclerosis And Experimental Autoimmune Encephalomyelitis?
Funder
National Health and Medical Research Council
Funding Amount
$56,797.00
Summary
Multiple sclerosis (MS) is a common neurological disease which affects about 10,000 people in Australia. In MS, a persons own immune system starts to attack specific parts of their brain and spinal cord, causing lesions that prevent nerve impulses from passing from the brain to other parts of the body. The symptoms that people with MS develop can vary from one person to another, depending on where in the brain or spinal cord the lesions occur. Some parts of the brain and spinal cord seem to be m ....Multiple sclerosis (MS) is a common neurological disease which affects about 10,000 people in Australia. In MS, a persons own immune system starts to attack specific parts of their brain and spinal cord, causing lesions that prevent nerve impulses from passing from the brain to other parts of the body. The symptoms that people with MS develop can vary from one person to another, depending on where in the brain or spinal cord the lesions occur. Some parts of the brain and spinal cord seem to be much more susceptible to this attack than others, and the question that this study will address is why do lesions occur where they do in MS? Some preliminary results strongly suggest that there is a link between carrying particular genes that control immune responses, having immune cells that can attack one particular protein in the nervous system called PLP, and developing lesions in parts of the brain that control balance. This will be investigated further, and we will also look for other links between immune cells that can attack other proteins and development of lesions in particular areas. If such links can be identified, they would be very important for improved diagnosis of MS and it would enable more specific treatments for MS to be developed. We will also use experimental models of MS to investigate the exact components within the nervous system and within the immune system that play a role in directing the attack to particular sites.Read moreRead less