Cognitive Behaviour Therapy For Posttraumatic Stress Disorder In Police Officers
Funder
National Health and Medical Research Council
Funding Amount
$190,255.00
Summary
Posttraumatic stress disorder (PTSD) is a significant anxiety disorder that affects many serving police officers. Although cognitive behaviour therapy (CBT) is the treatment of choice to treat PTSD, it has never been validated in police offcers. This project represents the first controlled trial of applying CBT to reduce PTSD in police officers.
Out-of-hospital cardiac arrest is fatal without immediate resuscitation. Paramedic competency in resuscitation has been shown to influence cardiac arrest survival. Through my doctoral research I aim to investigate: how paramedic exposure to cardiac arrest can influence patient survival; the practices emergency medical services currently use to develop and maintain paramedic competency in resuscitation; and the confidence and perceived competency of paramedics responding to cardiac arrests.
Reduction Of Oxygen After Cardiac Arrest: The EXACT Trial
Funder
National Health and Medical Research Council
Funding Amount
$1,891,021.00
Summary
We aim to conduct a Phase 3 multi-centre, randomised, controlled trial to determine whether reducing oxygen administration to target a normal level as soon as possible following successful resuscitation from out-of-hospital cardiac arrest, compared to current practice of maintaining 100% oxygen, improves patient survival at hospital discharge.
Functional Pharmacogenetics: Analysis Of The Functional Effect Of The IL28B Genotype On Hepatitis C Virus Infection And Treatment Response.
Funder
National Health and Medical Research Council
Funding Amount
$93,843.00
Summary
An estimated 3% of the world�s population is infected with hepatitis C virus (HCV). With low spontaneous clearance rates and often a poor response to treatment many infected individuals will develop long term complications from HCV. Recent studies have identified a genetic variant that is significantly associated with spontaneous viral clearance of HCV and response to treatment for HCV. We propose to further investigate the functional basis for the effect of this human genotype on drug response.
Role Of PLZF In Regulating The Interferon Response
Funder
National Health and Medical Research Council
Funding Amount
$531,696.00
Summary
The Interferon (IFN) pathway is essential for immune defense against pathogens in vertebrates. IFNs both protect and alert cells about viral, bacterial, and other immune assaults and promote a cellular antiviral state, reduce proliferation, or induce apoptosis depending on the cell type and environment. Based on these properties, IFNs have been used clinically against a variety of diseases including viral infections, immunomodulatory disorders and hematologic and solid tumors including renal cel ....The Interferon (IFN) pathway is essential for immune defense against pathogens in vertebrates. IFNs both protect and alert cells about viral, bacterial, and other immune assaults and promote a cellular antiviral state, reduce proliferation, or induce apoptosis depending on the cell type and environment. Based on these properties, IFNs have been used clinically against a variety of diseases including viral infections, immunomodulatory disorders and hematologic and solid tumors including renal cell carcinoma. However, the factors determining outcome of IFN treatment, remain to be determined. We have identified a subset of interferon stimulated genes whose sustained expression was found to correlate with heightened antiviral sensitivity of renal cell carcinoma cell lines to IFN. Many of these genes were found to have binding sites for the transcriptional repressor promyleocytic zinc finger protein (PLZF). PLZF was first identified in a subset of Acute Promyelocytic Leukemia patients and is involved in maintenance of erythroid lineage stem cells and spermatogonial stem cells in male mice. PLZF has not previously been implicated in the IFN response. Accordingly, we investigated the expression of interferon stimulated genes and showed that increased expression of immune related genes depends on PLZF expression. PLZF was also found to directly associate with binding sites in promoters of interferon stimulated genes and that this requires histone deacetylation. Thus, we uncovered a novel function for PLZF in enhancement of IFN associated gene expression. We propose to test the hypothesis that PLZF is an essential component of the IFN response. As a corollary, we will also test whether PLZF expression can be linked to IFN responsiveness in renal cell carcinoma. These studies will establish the role of PLZF in the IFN response and define its utility in predicting IFN responsiveness in therapeutic applications.Read moreRead less
Centre Of Research Excellence In Prehospital Emergency Care
Funder
National Health and Medical Research Council
Funding Amount
$2,499,626.00
Summary
The Prehospital Emergency Care - Centre for Research Excellence (PEC-CRE) will build capacity in prehospital research in Australia through the conduct of collaborative research projects between academic researchers, clinicians and ambulance service providers. The overarching goal of the PEC-CRE will be to strengthen the evidence base underpinning prehospital emergency care policy and practice, to ensure that ambulance patients receive ‘the right care, in the right place, at the right time’.
A Randomised Control Trial Evaluating Outcomes Of An Emergency Nurse Practitioner Service.
Funder
National Health and Medical Research Council
Funding Amount
$83,149.00
Summary
This proposed research will provide much needed evidence on this reform model. Health services research struggles to establish an inquiry context that is flexible to study service-level interventions using the gold standard of a randomised controlled trail (RCT). This proposed research will be conducted in a health service environment with a stable E-NP service innovation and capacity to randomise patient participants.
The RINSE Trial: The Rapid Infusion Of Cold Normal SalinE By Paramedics During CPR
Funder
National Health and Medical Research Council
Funding Amount
$708,241.00
Summary
Sudden cardiac arrest is a common event in the community. Therapeutic hypothermia decreases the brain injury caused by the cardiac arrest and is currently used in the hospital after successful resuscitation. However, there may be better outcomes if the brain is cooled by paramedics during resuscitation. We will compare survival rates for those patients cooled early by paramedics using an infusion of ice-saline during cardiac arrest with those patients who are later cooled by the hospital.