Improving Respiratory Transition And Outcomes Of Newborn Infants
Funder
National Health and Medical Research Council
Funding Amount
$262,251.00
Summary
Effective mask ventilation is the most important intervention at birth that can reduce mortality and disability in term and preterm infants. I will develop strategies to help clinicians improve their resuscitation skills. I will also study new ways to better support babies’ transition after birth, to improve their short and long term outcomes. The results of this research will change the way newly born babies are cared for around the world.
A Subphenotyping Approach To Identifying Genes Responsible For Isolated Clefts Of The Lip And Palate.
Funder
National Health and Medical Research Council
Funding Amount
$679,707.00
Summary
Clefts of the lip and palate are the most common birth defects involving the face. The genes responsible for these conditions have been difficult to find in the past. We have identified a method through which the chances of finding these genes is greatly increased. Detailed measurements of a number of facial features in cleft patients and unaffected first-degree relatives will provide a much clearer picture of those at higher risk of being affected by this debilitating disorder.
Premature babies often need assistance to breathe but this can injure the lung and lead to abnormal lung development and long-term lung disease. We have recently identified 3 factors that we believe are fundamental to initiating this abnormal lung development. We will demonstrate that these 3 factors mediate abnormal lung development following lung injury at birth. This information can then be used to reduce the incidence and severity of chronic lung disease of the newborn.
I am an orthopaedic surgeon and clinician-scientist based at Sydney’s largest children’s hospital. My goal is to improve treatments for children with traumatic injuries and bone deformity. I have worked in bone research for over 20 years. My current research interests are finding new treatments for drug-resistant bacterial infections, treating genetic bone disease, and developing new medical devices to help children’s bones grow straight.
Centre For Clinical Research Excellence In Newborn Medicine
Funder
National Health and Medical Research Council
Funding Amount
$2,519,475.00
Summary
The Centre for Clinical Research Excellence in Newborn Medicine will study adverse outcomes for the brains and lungs of newborn babies; it will establish how often these occur in different types of babies (ranging from very premature babies, through to those born on time), investigate the different causes, develop treatments to either prevent or treat the adverse outcomes, determine the long-term consequences into adulthood, and continually re-evaluate the effectiveness of the various treatment ....The Centre for Clinical Research Excellence in Newborn Medicine will study adverse outcomes for the brains and lungs of newborn babies; it will establish how often these occur in different types of babies (ranging from very premature babies, through to those born on time), investigate the different causes, develop treatments to either prevent or treat the adverse outcomes, determine the long-term consequences into adulthood, and continually re-evaluate the effectiveness of the various treatment strategies designed to improve the health outcomes for newborn babies.Read moreRead less
Bronchopulmonary Dysplasia – A Regenerative Medicine Approach
Funder
National Health and Medical Research Council
Funding Amount
$480,406.00
Summary
Bronchopulmonary dysplasia is a major leading cause of morbidity and mortality in premature babies. There is no cure. We have previously shown that amnion epithelial cells can reduce the extent of lung damage during early stages of lung development. We aim to understand how amnion cells can promote repair by interacting with existing cell types in order to restore normal lung structure and function. The outcomes from this study will help design clinical trials and develop new therapies.
DETERMINING THE MECHANISMS LEADING TO LONG-TERM IMPAIRMENT IN VERY PRETERM CHILDREN: THE VIBeS LONGITUDINAL STUDY.
Funder
National Health and Medical Research Council
Funding Amount
$1,061,733.00
Summary
Approximately 50% of children born very preterm will develop significant problems. The objective of this project is to determine the mechanisms leading to these problems. We will do this by assessing at school-age a unique and valuable cohort of very preterm infants (VIBeS cohort) who had state-of-the-art brain scans shortly after birth and neurobehaviour assessments across early childhood. This school-age follow-up will involve repeat brain scans and detailed neuropsychological assessments.
Characterising Lung Growth And Development In Health And Disease
Funder
National Health and Medical Research Council
Funding Amount
$451,716.00
Summary
A/Prof Graham Hall is senior researcher at the Telethon Institute for Child Health Research in Perth, Western Australia and is internationally recognised for his research in the area of respiratory physiology in infants and young children. His research focuses on understanding the impact of respiratory diseases, such as asthma and cystic fibrosis, as well as pre-term birth and air pollution on lung function not only in early life but as the lung grows and develops.
Aberrant Brain Development In High Risk Newborns: Relationship With Long Term Developmental Outcomes
Funder
National Health and Medical Research Council
Funding Amount
$185,932.00
Summary
Brain development and long term outcomes are altered in high-risk babies. This research looks at the developmental outcomes of 3 high-risk baby groups i.e. late preterm babies (born 4-8 weeks premature), babies with seizures, and preterm babies who have received probiotics in the newborn nursery. In addition, how their brain development may be different compared with healthy term babies will be studies using advanced magnetic resonance imaging.