How Regular Exercise Protects The Heart From Psychological Stresses
Funder
National Health and Medical Research Council
Funding Amount
$357,699.00
Summary
Regular exercise helps to protect the heart from the harmful effects of psychological stress. The present project seeks to discover the mechanisms that underpin this beneficial effect. The results will help to design new treatments that can augment the health benefits of exercise and provide an alternative for physically impaired individuals. The project may also allow to identify biochemical markers that can be used to optimise exercise program design for individuals and clinical populations.
Saving Sight Through Novel BioTech Innovations For Inherited Retinal Disease
Funder
National Health and Medical Research Council
Funding Amount
$1,534,523.00
Summary
Inherited retinal diseases (IRDs) are the leading cause of blindness in working-aged adults. My work focuses on learning more about IRDs, including the correlation between genes and the degenerative changes in the eye. I am developing new outcome measures to predict who might lose vision faster, and to use in clinical trials. I will then use this knowledge in two clinical trials for new IRD treatments - a gene therapy and an electronic device that is implanted into the eye.
Predicting Treatment Response To Onabotulinumtoxin-a In MS-related Tremor: A Combined Clinical, Electrophysiological And Neuroimaging Approach.
Funder
National Health and Medical Research Council
Funding Amount
$546,359.00
Summary
Shaking (tremor) of the upper limbs occur in many people with multiple sclerosis (MS). We have previously shown that botulinum toxin (Botox) injections could help reduce tremor. This study aims to study the effect of Botox in a larger group of people with MS and will include detailed MRI scans and electrical tremor monitoring tests to define the underlying changes in the brain that causes tremor. The results will help make Botox available as a tremor treatment for people with MS.
Epicardial Mapping Of Persistent Atrial Fibrillation. Identifying AF Mechanisms In Different Atrial Substrates.
Funder
National Health and Medical Research Council
Funding Amount
$654,341.00
Summary
Atrial fibrillation (AF) is a very common heart rhythm disturbance (arrhythmia) which carries with it an increased risk of having a stroke and a twofold risk of dying. At present, we still have only a limited understanding of the mechanism of AF when it becomes persistent. The aim of this study is to determine the critical mechanism of persistent AF in patients with different types of heart conditions. This knowledge is fundamental to the development of more successful curative approaches.
Determining The Best Outcome Measures For Assessing Cost-Effectiveness Of Interventions For Childhood Mental Disorders
Funder
National Health and Medical Research Council
Funding Amount
$473,837.00
Summary
The aim of this study is to evaluate which are the best outcome measures to use to assess the cost-effectiveness of interventions and services for children with mental disorders. The study will have great policy and practice relevance as it will help ensure that only services and interventions which work and provide good-value-for money are offered to children with such problems.