Development of an endofunctional capsule for targeted delivery of biomarkers in the alimentary tract. The proposed capsule will provide a solution to the problem of accessing the small intestine for targeted delivery of biomarkers and drugs, and contribute to translational medical research to enhance our understanding of the function of the gut. Successful completion of this project will build on defined priority areas of research strength in Australia (frontier technologies, smart information u ....Development of an endofunctional capsule for targeted delivery of biomarkers in the alimentary tract. The proposed capsule will provide a solution to the problem of accessing the small intestine for targeted delivery of biomarkers and drugs, and contribute to translational medical research to enhance our understanding of the function of the gut. Successful completion of this project will build on defined priority areas of research strength in Australia (frontier technologies, smart information use) and assist in the provision of information critical to the design of novel in vivo endofunctional devices. The technologies to be developed in this project will be translatable to the development of other in vivo functional investigation and treatment devices. Read moreRead less
New techniques for modelling, diagnosis and counter measures for cardiac related sleep disordered breathing. Around 50% of congestive heart failure sufferers have some form of sleep disordered breathing. However, little has been done so far to simultaneously monitor, analyse and treat the two conditions. Therefore, this project proposes to develop new technology incorporating mathematical models for heart rate variability, considering the links between sleep disordered breathing and cardiovasc ....New techniques for modelling, diagnosis and counter measures for cardiac related sleep disordered breathing. Around 50% of congestive heart failure sufferers have some form of sleep disordered breathing. However, little has been done so far to simultaneously monitor, analyse and treat the two conditions. Therefore, this project proposes to develop new technology incorporating mathematical models for heart rate variability, considering the links between sleep disordered breathing and cardiovascular disease. This innovation will enable, for the first time, a device capable of accurate and reliable diagnosis of various sleep disorders using only conventional ECG data. Such technology has the potential to produce significant community health benefits, and save several millions of lives worldwide.Read moreRead less
Spectroscopy of complex and biological micro-objects for biosensing applications. The optically based test for specific DNA binding resulting from the conclusion of this project is of great potential benefit to all Australians as DNA is the building block of all living organisms. The technique developed and resulting biosensor will provide an invaluable tool for the determination and analysis of specific DNA reactions. The general technique developed for the genetic targeting of specific DNA rea ....Spectroscopy of complex and biological micro-objects for biosensing applications. The optically based test for specific DNA binding resulting from the conclusion of this project is of great potential benefit to all Australians as DNA is the building block of all living organisms. The technique developed and resulting biosensor will provide an invaluable tool for the determination and analysis of specific DNA reactions. The general technique developed for the genetic targeting of specific DNA reactions makes the detection of diseases and toxins like Chlamydia and anthrax, for example cheap, quick and accurate, keeping Australian's healthy, and strengthening national security.Read moreRead less
Multiphoton microscopy through tissue turbid media. The aim of this proposal is to conduct the collaborative project on multi-photon microscopic imaging through biological tissue, which has been recently initiated between Swinburne University of Technology (SUT) and Massachusetts Institute of Technology (MIT). It will integrate the special skills, two-photon fluorescence endoscopy and second-harmonic coherence tomography, investigated in the respective collaborating institutes, to develop a nove ....Multiphoton microscopy through tissue turbid media. The aim of this proposal is to conduct the collaborative project on multi-photon microscopic imaging through biological tissue, which has been recently initiated between Swinburne University of Technology (SUT) and Massachusetts Institute of Technology (MIT). It will integrate the special skills, two-photon fluorescence endoscopy and second-harmonic coherence tomography, investigated in the respective collaborating institutes, to develop a novel method for detecting/imaging cancer cells that are located at 1 mm below tissue surfaces, while they are still in the early stage to be cured. Consequently, a diagnostic method for early cancer detection particularly through skin tissue becomes possible.Read moreRead less
Advanced technologies for laser refractive surgery. People who wear glasses can now undergo laser eye-surgery to correct their focussing problems. While many can ?throw away their glasses?, the results are optimised for one viewing situation so that when people move their eyes or refocus, visual clarity is not perfect. We need precise measurements of the eye's shape under dynamic conditions to understand exactly how optical distortions (aberrations) affect clarity of sight. This project is to b ....Advanced technologies for laser refractive surgery. People who wear glasses can now undergo laser eye-surgery to correct their focussing problems. While many can ?throw away their glasses?, the results are optimised for one viewing situation so that when people move their eyes or refocus, visual clarity is not perfect. We need precise measurements of the eye's shape under dynamic conditions to understand exactly how optical distortions (aberrations) affect clarity of sight. This project is to build a laser device that incorporates a deformable mirror to investigate the interplay between aberrations and visual clarity. This new knowledge is a vital next step to improve laser eye-surgery success.Read moreRead less
Functional nonlinear optical endoscopy - the third-generation optical endoscopy technology toward early cancer detection at a cellular level. The third-generation optical endoscopy technology can be used for a better understanding of nonlinear optical interaction with organ sites and thus for early cancer detection. Such a novel device will enable biomedical scientists to gain the fundamental knowledge needed to enable Australians to develop better medical strategies for health and productive li ....Functional nonlinear optical endoscopy - the third-generation optical endoscopy technology toward early cancer detection at a cellular level. The third-generation optical endoscopy technology can be used for a better understanding of nonlinear optical interaction with organ sites and thus for early cancer detection. Such a novel device will enable biomedical scientists to gain the fundamental knowledge needed to enable Australians to develop better medical strategies for health and productive lives. Since 1 in 3 Australians will feel the effects of cancers, development of portable nonlinear optical endoscopes is of national importance, in particular for rural Australia, and therefore improves the healthcare of human beings. The potential spin-off activity will lead to economic benefits from new R&D development.Read moreRead less
Microcharacterisation of rare-earth-doped optical fibres. Rare-earth-doped optical fibres continue to play a central role in optical telecommunication systems and are increasingly being used as elements in optical fibre sensing devices and as fibre lasers. The aim of this project is the application of new high spatial resolution techniques for determining the physical properties of such fibres. These methods will permit unprecedented knowledge of the precise distribution of rare-earth ions in th ....Microcharacterisation of rare-earth-doped optical fibres. Rare-earth-doped optical fibres continue to play a central role in optical telecommunication systems and are increasingly being used as elements in optical fibre sensing devices and as fibre lasers. The aim of this project is the application of new high spatial resolution techniques for determining the physical properties of such fibres. These methods will permit unprecedented knowledge of the precise distribution of rare-earth ions in the fibre and its relationship with the fibre's refractive index profile. This information is critical to understanding the performance of rare-earth-doped fibres in a variety of applications and the outcomes of this work will inform the design of fibres optimised for use in specific applications.Read moreRead less
Quantitative polarisation phase microscopy: A new tool for advances in structural analysis and biophotonics. Innovation in biomedical research is driven by technology in optical imaging. Optical imaging methods including polarisation microscopy are widely accepted and are at the forefront of biomedical scientific discoveries. This project undertakes fundamental and applied research innovatively combining polarisation imaging and quantitative phase imaging microscopy to uniquely quantify the phys ....Quantitative polarisation phase microscopy: A new tool for advances in structural analysis and biophotonics. Innovation in biomedical research is driven by technology in optical imaging. Optical imaging methods including polarisation microscopy are widely accepted and are at the forefront of biomedical scientific discoveries. This project undertakes fundamental and applied research innovatively combining polarisation imaging and quantitative phase imaging microscopy to uniquely quantify the physical thickness and morphology of birefringent specimens such as the cardiac muscle cell. This project, while of substantial intellectual merit in its own right, could also have the potential to lead to the detection of the mechanisms related to heart failure. Read moreRead less
Formation of Nanoporous titanium dioxide (TiO2) by Anodization of Titanium Thin Films. The development of nanoporous titanium dioxide (TiO2), with pore diameter less than 25 nm, represents a significant advance for both R&D and industrial applications. It is an invaluable material for the manufacture of a range of electronic and optical devices. These structures can be employed for the development of efficient thermoelectric coolers, highly sensitive biosensors as well as optical micro-devices w ....Formation of Nanoporous titanium dioxide (TiO2) by Anodization of Titanium Thin Films. The development of nanoporous titanium dioxide (TiO2), with pore diameter less than 25 nm, represents a significant advance for both R&D and industrial applications. It is an invaluable material for the manufacture of a range of electronic and optical devices. These structures can be employed for the development of efficient thermoelectric coolers, highly sensitive biosensors as well as optical micro-devices with high refractive index. In addition, nanoporous TiO2 has numerous applications in the fields of nanotechnology, bioengineering, diagnostics, materials science, and in the building industry. Australia will greatly benefit from the research and development of such a product with its promising market.Read moreRead less
Adaptive aberration compensation in high refractive index materials for next-generation active microphotonic devices. The method proposed in this project is a very promising and versatile method to compensate the strong aberration in a high refractive index material. The successful compensation of such aberration will allow people to fabricate microdevices directly inside high refractive index materials. This project will greatly advance optical fabrication techniques and expand the national kno ....Adaptive aberration compensation in high refractive index materials for next-generation active microphotonic devices. The method proposed in this project is a very promising and versatile method to compensate the strong aberration in a high refractive index material. The successful compensation of such aberration will allow people to fabricate microdevices directly inside high refractive index materials. This project will greatly advance optical fabrication techniques and expand the national knowledge in the area of nonlinear PhCs (photonic crystals) and related applications. It is expected that the project will provide many chances for postgraduate students to be involved. In future, nonlinear PhCs and related devices may be widely used in daily life and this project may provide some opportunities for industry.Read moreRead less