Improving Chronic Disease Outcomes For Indigenous Australians: Causes,Interventions, System Change
Funder
National Health and Medical Research Council
Funding Amount
$8,788,853.00
Summary
Diabetes and cardiovascular diseases occur in epidemic proportions among Indigenous Australians, with very early age of onset and high rates of preventable complications. This Program will bring together a multi skilled team of researchers with Indigenous partners to better understand the development of these conditions, and to guide the development of diet, lifestyle, clinical and health system interventions in order to minimise their adverse impacts and improve health overall.
Understanding The Major Class Of Cell Surface Drug Targets
Funder
National Health and Medical Research Council
Funding Amount
$7,595,840.00
Summary
G Protein-Coupled Receptors (GPCRs) form the largest family of receptors and drug targets in living organisms. Currently, the major reason that new drugs fail to reach the clinic is lack of appropriate drug effect (approx. 30%). Thus, we need a better understanding of how GPCRs work and how this relates to disease. Our Program addresses this knowledge gap, using GPCR models that are relevant to treatment of metabolic, inflammatory, cardiovascular and central nervous system disease.