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Disease Registry Based Approaches To Determining Molecular Risk Factors For Glaucoma Blindness, And Applying Them In Clinical Practice
Funder
National Health and Medical Research Council
Funding Amount
$406,355.00
Summary
The Practitioner-Fellow has drawn together very large cohorts of patients from Australia, New Zealand and now internationally who have lost vision from Glaucoma and complications of Diabetes to determine the contributing factors. He has successfully identified major clinical and genetic risk factors for these diseases, and is now applying the knowledge to patients in early stages of disease, so that earlier and more aggressive treatment high risk individuals can lead to improved outcomes.
Improving Clinical Understanding And Management Of Tendinopathy
Funder
National Health and Medical Research Council
Funding Amount
$487,621.00
Summary
Painful tendons occur in people of all ages. Treatment outcomes are variable and many people are left with chronic pain and limited capacity to be active. This research will investigate the development of tendinopathy, the cause of tendon pain and examine imaging methods to improve management. This research expects to demonstrate that tendon injury develops during puberty, that the brain has a central role in tendon pain, and that regular monitoring of tendon structure can improve outcomes.
Atrial fibrillation is the most common heart rhythm disturbance with a prevalence of approximately 1% but which increases markedly with age. It causes debilitating symptoms, heart failure, stroke and increased mortality. It is an important determinant of neuro-cognitive decline and dementia. The studies in this proposal will help define the mechanism of this rhythm disturbance and its associated symptoms. They will help design improved treatment strategies including interventional approaches.