Discovery Early Career Researcher Award - Grant ID: DE210101666
Funder
Australian Research Council
Funding Amount
$395,588.00
Summary
Engineering nanoparticles with enhanced adhesion at the nano-bio interfaces. This project aims to develop a next-generation adhesive nanoparticle platform through in-depth understandings of nanoparticle interactions with bio-interfaces. This project expects to generate new knowledge in the multidisciplinary research field at nano-bio-interfaces by using a recently developed nano-colloidal probe technology, instructing the rational design of nanoparticles with enhanced interface adhesive properti ....Engineering nanoparticles with enhanced adhesion at the nano-bio interfaces. This project aims to develop a next-generation adhesive nanoparticle platform through in-depth understandings of nanoparticle interactions with bio-interfaces. This project expects to generate new knowledge in the multidisciplinary research field at nano-bio-interfaces by using a recently developed nano-colloidal probe technology, instructing the rational design of nanoparticles with enhanced interface adhesive properties. Expected outcomes include a family of adhesive nanoparticles designed for nanopesticide and animal feed applications, with the potential to deliver valuable intellectual property of commercial interest and economic benefit through technology advancement.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE170100068
Funder
Australian Research Council
Funding Amount
$390,000.00
Summary
Bioinspired liposome-based smart sensors. This project aims to develop a liposome-based biosensor technology that mimics cell sensory systems. Selective detection of compounds is increasingly important for food, health and environmental monitoring. Biosensor development faces long-standing challenges such as response time, sensitivity, specificity, and multiplexing. On the other hand, cells can sense and discriminate multiple biomolecules in seconds with high sensitivity and specificity. This pr ....Bioinspired liposome-based smart sensors. This project aims to develop a liposome-based biosensor technology that mimics cell sensory systems. Selective detection of compounds is increasingly important for food, health and environmental monitoring. Biosensor development faces long-standing challenges such as response time, sensitivity, specificity, and multiplexing. On the other hand, cells can sense and discriminate multiple biomolecules in seconds with high sensitivity and specificity. This project aims to harness cells’ exquisite biological properties to improve current detection techniques. It will integrate liposome-based sensors with microfluidics to perform analytical tasks ranging from food safety to diagnostics.Read moreRead less
Cell Membrane Coated Photonic Crystal to study Receptor-Ligand Interactions. The current gold-standard assays for examining receptor-ligand interactions require expensive and costly fluorescent or radioactive labels or proteomics processes. This project aims to develop Artificial Photonic Cells by directly coating photonic crystals with cell membranes. The Artificial Photonic Cells retain the protein receptors in their native cell membrane environment and allow for label-free monitoring of the r ....Cell Membrane Coated Photonic Crystal to study Receptor-Ligand Interactions. The current gold-standard assays for examining receptor-ligand interactions require expensive and costly fluorescent or radioactive labels or proteomics processes. This project aims to develop Artificial Photonic Cells by directly coating photonic crystals with cell membranes. The Artificial Photonic Cells retain the protein receptors in their native cell membrane environment and allow for label-free monitoring of the receptor-ligand interactions using inexpensive miniature spectrometers - radically transforming these assays. This would generate fundamental and applied knowledge of materials sciences, photonic, and biointerfaces for label-free, ultra-sensitive, and selective assays to enable future drug and diagnostics target discovery. Read moreRead less
Spinning Nanosheets for Versatile Applications. This project seeks to develop a highly versatile and innovative fibre spinning research platform for fabricating multifunctional hybrid fibres with unprecedented mechanical, electrical and electrochemical properties. The novel fibres to be produced can be assembled into macroscale architectures or be weaved into functional textiles that can feed into relevant technologies and Australian industries such as advanced textiles for wearable energy stora ....Spinning Nanosheets for Versatile Applications. This project seeks to develop a highly versatile and innovative fibre spinning research platform for fabricating multifunctional hybrid fibres with unprecedented mechanical, electrical and electrochemical properties. The novel fibres to be produced can be assembled into macroscale architectures or be weaved into functional textiles that can feed into relevant technologies and Australian industries such as advanced textiles for wearable energy storage and conversion, microelectrodes and sensors, and smart medical/biomedical platforms. More importantly, this project will have far reaching implications across a range of research disciplines, and ultimately sectors critical to Australia’s health, social, and economic future.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE200100186
Funder
Australian Research Council
Funding Amount
$233,000.00
Summary
The 3D Nanofabrication Facility. This project aims to breach the gap between meso, micro and nanoscale manufacturing by means of a novel 3D printing technique with nanometric resolution. This project expects to generate new knowledge in the technologies to fabricate complex structures with freedom of design from the meso to the nanoscale, currently not possible in Australia, by using the innovative integration of this technique within a well establish nanofabrication facility. Expected outcomes ....The 3D Nanofabrication Facility. This project aims to breach the gap between meso, micro and nanoscale manufacturing by means of a novel 3D printing technique with nanometric resolution. This project expects to generate new knowledge in the technologies to fabricate complex structures with freedom of design from the meso to the nanoscale, currently not possible in Australia, by using the innovative integration of this technique within a well establish nanofabrication facility. Expected outcomes of this project include new discoveries in fields such as nanotechnology, photonics, robotics, metamaterials, biosurface engineering or biotechnology. This should provide significant benefits, such as placing Australia in the leadership of nanotechnology and additive manufacturing.Read moreRead less
A New Platform of Bio-inspired Nanoparticles for Enhanced Cellular Delivery. Delivery of various molecules into cells is crucial in modern medicine. Compared to viral vectors, non-viral vectors are safer delivery vehicles, but their delivery efficiency must be improved before they can be broadly used. Inspired by the surface topography of viruses with high infectivity, this project aims to provide a fundamental understanding of the impact of surface roughness on cellular delivery efficiency; and ....A New Platform of Bio-inspired Nanoparticles for Enhanced Cellular Delivery. Delivery of various molecules into cells is crucial in modern medicine. Compared to viral vectors, non-viral vectors are safer delivery vehicles, but their delivery efficiency must be improved before they can be broadly used. Inspired by the surface topography of viruses with high infectivity, this project aims to provide a fundamental understanding of the impact of surface roughness on cellular delivery efficiency; and to use this knowledge in the designed synthesis of a new family of bio-inspired non-viral nanoparticles with both safety and high cellular delivery efficiency. The new and high performance nano-carriers will become a platform technology with broad bio-applications in gene therapy, cancer therapy and bio-imaging.Read moreRead less
Multimodal biomedical imaging probes: development of advanced polymer nanocomposite devices for oncology. Despite significant research being directed toward cancer treatment, 7.6 million people died world wide in 2007. Early detection and treatment is widely recognised as being effective in significantly reducing mortality rates. Biomedical imaging techniques are routinely used for detection and staging of many cancers. However, greater sensitivity is required so that these techniques can be app ....Multimodal biomedical imaging probes: development of advanced polymer nanocomposite devices for oncology. Despite significant research being directed toward cancer treatment, 7.6 million people died world wide in 2007. Early detection and treatment is widely recognised as being effective in significantly reducing mortality rates. Biomedical imaging techniques are routinely used for detection and staging of many cancers. However, greater sensitivity is required so that these techniques can be applied to very early detection of tumours. To overcome this short-coming the next generation of imaging probes will be developed, which will require fundamental investigations in polymer and nanomaterials science to maximise imaging sensitivity and extend probe functionality. Successful outcomes will lead to significant benefits to healthcare in Australia.Read moreRead less
Probing the function of protein molecular motors on nano-fabricated structures. The function of protein linear molecular motors, which are natural dynamic bio-nano-devices with a ubiquitous importance in multicellular organisms, will be 'probed' with purposefully designed nano-structures fabricated via photo- or Scanning Probe Microscopy Lithography, that is, flat polymeric surfaces with combinatorial combinations of physico-chemistries; and micro/nano-channels and nano-wells with critical dimen ....Probing the function of protein molecular motors on nano-fabricated structures. The function of protein linear molecular motors, which are natural dynamic bio-nano-devices with a ubiquitous importance in multicellular organisms, will be 'probed' with purposefully designed nano-structures fabricated via photo- or Scanning Probe Microscopy Lithography, that is, flat polymeric surfaces with combinatorial combinations of physico-chemistries; and micro/nano-channels and nano-wells with critical dimensions similar to the scale of the probed biomolecules. The project turns 'up-side down' the challenge of invasive nano-probing of biomolecules using it in an engineered manner. The fundamental understanding of linear molecular motors will impact on biomedical science and on the assessment of hybrid natural-artificial dynamic nano-devices.Read moreRead less
Nanoarchitectured multifunctional porous superparamagnetic nanoparticles. This project aims to develop a method for the direct detection of biomarkers based on a new class of highly porous superparamagnetic nanoparticles with peroxidase-like activity. The particles will be used as dispersible capture agents for isolating specific targets in biological samples, and electrocatalytic nanozymes for naked-eye evaluation and electrochemical detection. The project is expected to develop simple, low-cos ....Nanoarchitectured multifunctional porous superparamagnetic nanoparticles. This project aims to develop a method for the direct detection of biomarkers based on a new class of highly porous superparamagnetic nanoparticles with peroxidase-like activity. The particles will be used as dispersible capture agents for isolating specific targets in biological samples, and electrocatalytic nanozymes for naked-eye evaluation and electrochemical detection. The project is expected to develop simple, low-cost, portable devices for the analysis of exosomes and exosomal miRNA in biological samples. The future development of this technology into diagnostic devices will improve patient outcomes by enabling earlier disease diagnosis and improved monitoring of treatment.Read moreRead less
DNA exhibits new self-assembled structures due to clustered DNA methylation. This project aims to develop a technology to investigate detailed epigenetic patterns in DNA by directly interrogating the physical properties of DNA polymers in their native state. Epigenetics controls whether genes and genetic programs are turned on or off in living systems. The project will build on a recent discovery that key physical properties of native DNA polymers are strongly influenced by epigenetic patterns c ....DNA exhibits new self-assembled structures due to clustered DNA methylation. This project aims to develop a technology to investigate detailed epigenetic patterns in DNA by directly interrogating the physical properties of DNA polymers in their native state. Epigenetics controls whether genes and genetic programs are turned on or off in living systems. The project will build on a recent discovery that key physical properties of native DNA polymers are strongly influenced by epigenetic patterns created by living organisms. By fully understanding this phenomenon, this project aims to provide new tools for the study of epigenetics with broad potential applications in the life sciences, biotechnology and nanotechnology.Read moreRead less