Placental nutrient transport shows how complex traits evolve. This project aims to use amino acid transport in the vertebrate placenta as a model to demonstrate how genes are recruited and modified to produce a major organ. Using an innovative combination of a new technology, selected reaction monitoring, and transcriptomic and molecular approaches, plus carefully selected Australian species pairs, this project will study the evolution of a complex trait (placental amino acid transport). The pr ....Placental nutrient transport shows how complex traits evolve. This project aims to use amino acid transport in the vertebrate placenta as a model to demonstrate how genes are recruited and modified to produce a major organ. Using an innovative combination of a new technology, selected reaction monitoring, and transcriptomic and molecular approaches, plus carefully selected Australian species pairs, this project will study the evolution of a complex trait (placental amino acid transport). The project will provide fundamental advances in our knowledge of the nutrient transport during pregnancy that is required to produce a healthy baby.Read moreRead less
How does the interaction between environmental drivers determine the impact of global change on animals? There is an urgent need to determine how vulnerable natural populations are to simultaneous changes in more than one environmental driver. This project will take an integrative approach, using molecular, physiological and ecological tools, to determine whether cellular responses to the interaction between UV-B radiation and temperature vary between populations, and within individuals over tim ....How does the interaction between environmental drivers determine the impact of global change on animals? There is an urgent need to determine how vulnerable natural populations are to simultaneous changes in more than one environmental driver. This project will take an integrative approach, using molecular, physiological and ecological tools, to determine whether cellular responses to the interaction between UV-B radiation and temperature vary between populations, and within individuals over time. This project will bridge the gap between physiology and ecology by testing whether molecular responses translate into fitness benefits for the organism to gain an understanding at a level that is relevant for conservation. Read moreRead less
Understanding the koala microbiome: unlocking the secrets of koala health and dietary specialisation, and successful husbandry and translocation. This project aims to discover how the composition and function of koala gastrointestinal microbial communities differ in space and time in response to the varying nutritional quality and chemical composition of koala diets. Using detailed chemical analysis, cutting edge metagenomic and bioinformatic pipelines and powerful approaches to study enzyme fun ....Understanding the koala microbiome: unlocking the secrets of koala health and dietary specialisation, and successful husbandry and translocation. This project aims to discover how the composition and function of koala gastrointestinal microbial communities differ in space and time in response to the varying nutritional quality and chemical composition of koala diets. Using detailed chemical analysis, cutting edge metagenomic and bioinformatic pipelines and powerful approaches to study enzyme functions in the koala’s gut, the investigators aims to reveal the role of microbes in detoxification of plant toxins and degradation of recalcitrant fibre fractions. The outcomes aim to facilitate the use of faecal transplants to improve digestive function for translocated and rehabilitated koalas, enhancing options for koala management and conservation.Read moreRead less