A terrestrial hot spring setting for the origin of life. This project aims to test the proposal that a terrestrial hot spring field could have been the setting for the origin of life, in preference over the currently favoured site at deep sea vents. The project will involve an integrated, and multi-disciplinary study of the rocks, fluids, and molecules that together make up ancient to modern hot spring systems, and experiments on prebiotic organic chemistry using early Earth materials. Results w ....A terrestrial hot spring setting for the origin of life. This project aims to test the proposal that a terrestrial hot spring field could have been the setting for the origin of life, in preference over the currently favoured site at deep sea vents. The project will involve an integrated, and multi-disciplinary study of the rocks, fluids, and molecules that together make up ancient to modern hot spring systems, and experiments on prebiotic organic chemistry using early Earth materials. Results will be used to develop a terrestrial origin of life setting and assist in the search for life on Mars.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100107
Funder
Australian Research Council
Funding Amount
$400,000.00
Summary
Purchase of a multi-purpose Schottky field emission gun scanning electron microscope. Scanning electron microscopy is a basic analytical tool for imaging surfaces of natural and synthetic materials and identification of nanometre-scale features and their compositions. At the University of Tasmania, it supports four of our six designated priority research themes: Antarctic and Marine Studies, Environment, Frontier Technologies, and Sustainable Primary Production. Our research depending on this te ....Purchase of a multi-purpose Schottky field emission gun scanning electron microscope. Scanning electron microscopy is a basic analytical tool for imaging surfaces of natural and synthetic materials and identification of nanometre-scale features and their compositions. At the University of Tasmania, it supports four of our six designated priority research themes: Antarctic and Marine Studies, Environment, Frontier Technologies, and Sustainable Primary Production. Our research depending on this technique includes many fundamental and applied topics from a wide range of disciplines, such as developing portable detection devices for explosives, finding more efficient and sustainable ways to explore for ore, investigating the effects of climate change on marine ecosystems and improving salinity and drought tolerance of crops.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0238898
Funder
Australian Research Council
Funding Amount
$352,000.00
Summary
Novel Optical Microprobes - fluorescence excitation, lifetime and surface enhanced Raman spectroscopies. State-of-the-art technologies in microscopy will be combined with the versatility and diagnostic power of spectroscopy for the analysis and identification of materials by methods sensitive to chemical structure as well as spatial inhomogeneity. The proposed systems will operate within an existing multi-user optical characterisation facility at Macquarie University thus supporting the research ....Novel Optical Microprobes - fluorescence excitation, lifetime and surface enhanced Raman spectroscopies. State-of-the-art technologies in microscopy will be combined with the versatility and diagnostic power of spectroscopy for the analysis and identification of materials by methods sensitive to chemical structure as well as spatial inhomogeneity. The proposed systems will operate within an existing multi-user optical characterisation facility at Macquarie University thus supporting the research of an established and expanding network of researchers in the Sydney area and in Melbourne. The suite of instruments will provide new and exciting avenues for interdisciplinary research between the physical and biological sciencesRead moreRead less
Open source drug discovery for malaria. This project aims to discover a new drug for the treatment of malaria. In stark contrast to the traditional process of drug discovery, and to accelerate the project's progress, the research will be open source, meaning that anyone can participate and there will be no patents.
Elucidating the Mode of Action of Nicotinic Receptor Ligands. Changes in brain function can cause human diseases such as epilepsy, schizophrenia and Alzheimer's disease. To develop new medicines to treat these conditions we need to study how drugs act in the brain. This project will use new methods of chemistry to make drugs, which will then be tested for biological activity at important brain receptors. This will tell us which compounds are most effective as potential drugs and also exactly whe ....Elucidating the Mode of Action of Nicotinic Receptor Ligands. Changes in brain function can cause human diseases such as epilepsy, schizophrenia and Alzheimer's disease. To develop new medicines to treat these conditions we need to study how drugs act in the brain. This project will use new methods of chemistry to make drugs, which will then be tested for biological activity at important brain receptors. This will tell us which compounds are most effective as potential drugs and also exactly where they act in the brain. Read moreRead less
Development of Pyrrolopyrimidines as Inhibitors of ATP-Binding Proteins. This project seeks to generate analogues of natural products that have been found to be active against cancer cells and tropical parasites. The new materials produced by this project will aid in the study of biochemical processes involved in diseases such as cancer and lymphatic filariasis, thus leading the way to development of these compounds as potential treatments for such diseases.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0236167
Funder
Australian Research Council
Funding Amount
$580,000.00
Summary
The Sydney Combinatorial Research Facility. The proposal is to establish a multidisciplinary inter-institutional research facility for solution-phase combinatorial chemistry synthesis and analysis, and medium to high throughput biological evaluation of lead compounds through fluorescence detection methods. This will be the first and only multi-user facility of its type in Sydney. It will provide through its synthetic node at NSW and Macquarie Universities and biological screening node at Univers ....The Sydney Combinatorial Research Facility. The proposal is to establish a multidisciplinary inter-institutional research facility for solution-phase combinatorial chemistry synthesis and analysis, and medium to high throughput biological evaluation of lead compounds through fluorescence detection methods. This will be the first and only multi-user facility of its type in Sydney. It will provide through its synthetic node at NSW and Macquarie Universities and biological screening node at University of Sydney an essential resource that will enable modern combinatorial techniques to be applied to chemical and drug-lead development studies in the region.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE180100050
Funder
Australian Research Council
Funding Amount
$744,100.00
Summary
New South Wales molecular analysis platform: Fourier transform ion cyclotron resonance mass spectrometer and CHN&S analyser. This project aims to provide critical infrastructure for research in the molecular sciences by providing state of the art mass spectrometry and elemental analysis instrumentation. The project will support research for over 100 groups in New South Wales (NSW) and will lead to new knowledge in a variety of areas. Expected outcomes include enhanced capacity and productivity, ....New South Wales molecular analysis platform: Fourier transform ion cyclotron resonance mass spectrometer and CHN&S analyser. This project aims to provide critical infrastructure for research in the molecular sciences by providing state of the art mass spectrometry and elemental analysis instrumentation. The project will support research for over 100 groups in New South Wales (NSW) and will lead to new knowledge in a variety of areas. Expected outcomes include enhanced capacity and productivity, new interdisciplinary collaborations and the discovery of novel materials and bioactive molecules, leading to wealth creation. The significant benefits of the NSW molecular analysis platform will include the ability to rapidly analyse molecules with the highest certainty, and will enhance the impact of Australian research via access to new technologies.Read moreRead less
The Development of Chemopropulsion-based Fluidic Transport Systems. The controlled transport of chemical species in fluidic systems is essential to the functioning of living systems. Emulating cellular transport processes in synthetic fluidic systems, so as to allow the controlled transport of reagents or products from one site to another, has the potential to add revolutionary capabilities to fluidic platforms. This project will explore the potential and limits of chemopropulsion and its use as ....The Development of Chemopropulsion-based Fluidic Transport Systems. The controlled transport of chemical species in fluidic systems is essential to the functioning of living systems. Emulating cellular transport processes in synthetic fluidic systems, so as to allow the controlled transport of reagents or products from one site to another, has the potential to add revolutionary capabilities to fluidic platforms. This project will explore the potential and limits of chemopropulsion and its use as a driving mechanism for cargo-carrying vehicles in fluids. The resulting fluidic transport systems could be used to transport medicine in the human body, act as chemical messengers for signal transduction in sensing or other systems or move cargo around microfluidic devices.Read moreRead less
Organometallic Transformations of Organic Compounds. The program will develop new metal-based catalysts for two main purposes (i) transforming basic hydrocarbons eg. natural gas and low-molecular-weight petroleum products into more advanced compounds (such as alcohols, alkenes and carboxylic acids); and (ii) converting nitrogen gas into nitrogen-containing compounds eg. ammonia or ammonia derivatives. In both projects, the aim is to take readily available and abundant starting materials that ar ....Organometallic Transformations of Organic Compounds. The program will develop new metal-based catalysts for two main purposes (i) transforming basic hydrocarbons eg. natural gas and low-molecular-weight petroleum products into more advanced compounds (such as alcohols, alkenes and carboxylic acids); and (ii) converting nitrogen gas into nitrogen-containing compounds eg. ammonia or ammonia derivatives. In both projects, the aim is to take readily available and abundant starting materials that are currently difficult to utilise and to design and develop specific reagents to convert them to "value-added" products. The program will also explore the mode of action of metal-based reagents leading to better reagent and catalyst design.Read moreRead less