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Diseases of the 21st century are complex with environmental and genetic causes. At the interface of these is Epigenetics - factors not specified by DNA sequence that control genes. Recent data show much of the risk associated with disease is set early in life, even during the time in the womb. The MCRI CDDE laboratory has assembled teams of researchers of diverse expertise investigating epigenetics of human development and complex disease to hopefully prevent or reverse them early in life.
Understanding The Shared Determinants And Causal Pathways Of Early Life Infection, Inflammation And Atherosclerosis.
Funder
National Health and Medical Research Council
Funding Amount
$632,803.00
Summary
Infection is the commonest reason for childhood hospitalisation, but it is unknown why infection is much more severe in some children. The long-term effects of infection on the development of atherosclerosis (hardening of the arteries), the underlying cause of cardiovascular disease, is also unknown. This research investigates these important questions with the aim of developing better prediction and prevention of severe infection and reducing its impact on adult cardiovascular disease.
Chronic Disease Epidemiology In Different Populations: Risk Factors, Detection And Prevention
Funder
National Health and Medical Research Council
Funding Amount
$621,458.00
Summary
To investigate causes, detection and prevention of diabetes, cardiovascular disease, and kidney disease in Aboriginal and international populations, I will maintain a long-term cohort with a 20-year follow-up in Aboriginal people and to analyse several large repeated cross-sectional data collected over 25 years in China. For the next 5 years, I will continue to to provide critical epidemiological evidence for the development of health policies and clinical guidelines related to chronic diseases ....To investigate causes, detection and prevention of diabetes, cardiovascular disease, and kidney disease in Aboriginal and international populations, I will maintain a long-term cohort with a 20-year follow-up in Aboriginal people and to analyse several large repeated cross-sectional data collected over 25 years in China. For the next 5 years, I will continue to to provide critical epidemiological evidence for the development of health policies and clinical guidelines related to chronic diseases in different populations.Read moreRead less
I am an epidemiologist using record linkage to investigate the causes and consequences of developmental disabilities such as birth defects, intellectual disability and autism and to identify possibilities for their prevention and amelioration.
Early Childhood Mental Health: Pathways, Treatment, Access, And Community Literacy.
Funder
National Health and Medical Research Council
Funding Amount
$849,540.00
Summary
Many causes, warning signs, and opportunities for intervention for mental health problems are evident in early childhood. This project will conduct research and innovative practice that will transform our understanding of mental health problems in early childhood, including improved understanding of the environmental/biological mechanisms, methods to best target and disseminate effective early intervention, and improve community literacy and reduce stigma for these children and their parents.
Cerebral Palsy is most common childhood physical disability. While the brain injury is static, disability can be progressive and lifelong. This fellowship aims to develop and test novel interventions to optimise neuroplasticity by improving early detection and physical, cognitive, psychological and health outcomes in children with CP. Earlier accurate detection of CP will ensure effective treatments utilise critical periods of brain development and are translated into evidence based guidelines.
Improving The Long-term Quality Of Life For Preterm Children
Funder
National Health and Medical Research Council
Funding Amount
$638,517.00
Summary
My vision is to improve the long-term quality of life of preterm children (<37 weeks’ gestation), with a specific focus on those born very preterm (VP; <32 weeks’ gestation). To achieve this goal my research has two broad and related aims: 1) Determine the neurological and socio-environmental mechanisms leading to impairments in preterm children; and 2) Develop and assess the efficacy of perinatal and early intervention programs for preterm children.
Outcome Prediction, Stratification And Novel Treatments In Individuals At Ultra High Risk Of Psychosis
Funder
National Health and Medical Research Council
Funding Amount
$774,540.00
Summary
The Ultra High Risk (UHR) criteria have been developed to identify people at high risk of psychotic disorders such as schizophrenia so that treatments can be provided early to reduce risk and disability. However the some UHR people are at risk of other difficulties and disorders and others are not at risk of all. We need to improve our ability to distinguish between these groups so that treatment can be tailored according to risk, and develop new treatments that target underlying problems.
Empowering The Community To Take Action On Prevention And Early Intervention For Mental Disorders
Funder
National Health and Medical Research Council
Funding Amount
$756,030.00
Summary
The vision of this application is to make Australia the world leader in research which empowers the community to take action for prevention and early intervention with mental disorders.
Innovative Models Of Early Intervention For Conduct Disorders In Children
Funder
National Health and Medical Research Council
Funding Amount
$826,854.00
Summary
Most mental health problems begin in childhood, and Oppositional-defiant and conduct problems are the most reliable precursor of adult mental health problems. The lifetime costs on public services for these children are large. Australia has no strategy for managing this problem, and urgently needs to develop evidence-based approaches. This program of research will develop improved methods for identifying, assessing and treating child conduct disorders as part of our national strategy for early i ....Most mental health problems begin in childhood, and Oppositional-defiant and conduct problems are the most reliable precursor of adult mental health problems. The lifetime costs on public services for these children are large. Australia has no strategy for managing this problem, and urgently needs to develop evidence-based approaches. This program of research will develop improved methods for identifying, assessing and treating child conduct disorders as part of our national strategy for early intervention for mental health.Read moreRead less