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Research Topic : Early Detection
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  • Funded Activity

    Linkage Projects - Grant ID: LP0990171

    Funder
    Australian Research Council
    Funding Amount
    $411,529.00
    Summary
    ABRA: improving foundational literacy through technology in regional and remote schools through a randomized controlled trial. Education outcomes in regional and remote Australia, particularly for Indigenous students, are worsening, to the point of constituting a national crisis. Skilled educators are not consistently available in sufficient numbers to arrest this trend in the early years by giving the intensive, continuous expert instruction required. Under limited pilot conditions, a web-base .... ABRA: improving foundational literacy through technology in regional and remote schools through a randomized controlled trial. Education outcomes in regional and remote Australia, particularly for Indigenous students, are worsening, to the point of constituting a national crisis. Skilled educators are not consistently available in sufficient numbers to arrest this trend in the early years by giving the intensive, continuous expert instruction required. Under limited pilot conditions, a web-based instructional tool known as ABRACADABRA has shown considerable promise as a means of conferring the foundational skills in literacy for emerging learners, despite high workforce turnover. Testing the effectiveness of ABRACADABRA under more stringent experimental conditions is an essential precursor to offering tested solutions based on evidence, not advocacy.
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    Funded Activity

    Immunising Aboriginal Mothers With Pneumococcal Polysaccharide Vaccine To Prevent Infant Ear Disease And Carriage

    Funder
    National Health and Medical Research Council
    Funding Amount
    $1,131,530.00
    Summary
    Aboriginal children experience the highest rates of acute and chronic ear infections in the world, with resultant permanent ear damage, hearing loss and educational disadvantage. These infections are mainly bacterial, and Streptococcus pneumoniae (pneumococcus) is the predominant pathogen. Pneumococcal colonisation and infection begins within days of birth, many months before any potential immunological protection from infant pneumococcal conjugate vaccine may be expected. New strategies are nee .... Aboriginal children experience the highest rates of acute and chronic ear infections in the world, with resultant permanent ear damage, hearing loss and educational disadvantage. These infections are mainly bacterial, and Streptococcus pneumoniae (pneumococcus) is the predominant pathogen. Pneumococcal colonisation and infection begins within days of birth, many months before any potential immunological protection from infant pneumococcal conjugate vaccine may be expected. New strategies are needed to eliminate, or at least delay, this early-onset pneumococcal colonisation. One such strategy is the administration to the mother of pneumococcal vaccine, which may protect the newborn infant by leading to higher titres of transplacental or breast milk pneumococcal antibodies and-or by reducing carriage (and transmission to the infant) of maternal pneumococci. Previous small studies using this strategy have been encouraging, but there have been no studies properly evaluating carriage or disease endpoints in infants. The polysaccharide pneumococcal vaccine is currently recommended for all Aboriginal and Torres Islander persons aged 15 years or more in the Northern Territory but uptake of the vaccine has been poor. We propose to conduct a pilot study to determine if maternal immunisation with this vaccine, either in the third trimester of pregancy of immediately following delivery, can reduce pneumococcal carriage and the prevalence of middle ear disease among Aboriginal infants at seven months of age. We aim to recruit 210 Aboriginal women who have uncomplicated pregnancies from Darwin and remote communities in the Top End of the Northern Territory. Each subject and their infant offspring will be followed-up after vaccination and at birth, one , two and seven months after birth.
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