New approaches for screening cereal germplasm for enhanced microbial pathogen resistance and desirable grain texture. The trait of grain hardness (texture) is of significance to the Australian infrastructure, as exports of hard wheat contribute over 5 billion dollars per year on average to the national economy and hard wheats are also important for domestic usage. The genes responsible for grain texture also impart resistance to bacterial and fungal pathogens which can cause extensive damage. ....New approaches for screening cereal germplasm for enhanced microbial pathogen resistance and desirable grain texture. The trait of grain hardness (texture) is of significance to the Australian infrastructure, as exports of hard wheat contribute over 5 billion dollars per year on average to the national economy and hard wheats are also important for domestic usage. The genes responsible for grain texture also impart resistance to bacterial and fungal pathogens which can cause extensive damage. However, the Australian gene pool has very limited genetic diversity in grain textures and thus possibly in pathogen resistance. The project will work out the science behind these two traits and identify lines with new variants of textures and pathogen resistances, thus greatly benefiting the national infrastructure and local primary industries.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE120102954
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Identifying and understanding the genetic regulators of cardiac development. The project aims to discover new genes involved in cardiac development so we can understand how to build a heart. Armed with this information, we can devise strategies for the repair of congenital and acquired heart disease.
Genetic dissection of cardiac morphogenesis. The human heart is critical for survival and yet, despite its importance, we still lack a basic understanding of how it forms. This project aims to discover new genes involved in cardiac development so we can understand how to build a heart. Armed with this information, this research will assist in devising strategies for the repair of congenital and acquired heart disease.
Understanding how the heart becomes more efficient. The body demands that the heart function at utmost efficiency. Trabeculae – folds within the heart lumen – maximise blood flow, contribute to chamber development and form the electrical conduction network of the heart. Problems with trabeculae formation cause cardiomyopathy and arrhythmia and yet we do not understand its basic development. The project will investigate the earliest stages of when this tissue develops its identity and examine the ....Understanding how the heart becomes more efficient. The body demands that the heart function at utmost efficiency. Trabeculae – folds within the heart lumen – maximise blood flow, contribute to chamber development and form the electrical conduction network of the heart. Problems with trabeculae formation cause cardiomyopathy and arrhythmia and yet we do not understand its basic development. The project will investigate the earliest stages of when this tissue develops its identity and examine the signalling, genetic, cellular and extracellular cues required to instruct trabeculae to form in the heart. Findings from this research will revise our understanding of when and how trabeculae form and provide key information about how to grow and repair this important tissue.Read moreRead less
CD151 and functional overlap in tetraspanins. The applicants are currently world leaders in the tetraspanin field. This project will enhance existing international collaborations to maintain and increase the applicants', and hence Australia's, international standing in this field and Australia's reputation in cell and molecular biology in general.
The project will greatly increase our understanding of this important but poorly understood family of proteins. It will also provide training opport ....CD151 and functional overlap in tetraspanins. The applicants are currently world leaders in the tetraspanin field. This project will enhance existing international collaborations to maintain and increase the applicants', and hence Australia's, international standing in this field and Australia's reputation in cell and molecular biology in general.
The project will greatly increase our understanding of this important but poorly understood family of proteins. It will also provide training opportunities for postgraduate students in state-of-the-art approaches in biotechnology.Read moreRead less
ARC Centre of Excellence in Biotechnology and Development. The Centre will create a multidisciplinary research team focusing on the molecular mechanisms that drive the specification and differentiation of male germ cells. This research will improve our fundamental understanding of how complex regulatory networks control the expression of a complex phenotype, the spermatozoon. It will also create a platform of knowledge from which we can stimulate the growth of the Australian Biotechnology indust ....ARC Centre of Excellence in Biotechnology and Development. The Centre will create a multidisciplinary research team focusing on the molecular mechanisms that drive the specification and differentiation of male germ cells. This research will improve our fundamental understanding of how complex regulatory networks control the expression of a complex phenotype, the spermatozoon. It will also create a platform of knowledge from which we can stimulate the growth of the Australian Biotechnology industry, the protection of the Australian Environment and the well-being of the Australian people. Key issues for this Centre include testicular cancer, male infertility, contraception, pest animal control, environmental impacts on human health and gene pharming.Read moreRead less
Deciphering the cellular functions of caveolae that govern lymphatic vascular development. Lymphatic vessels play crucial roles in tissue fluid homeostasis, immunity, and fatty acid transport. Despite our recent understanding of genetic pathways that modulate lymphatic cell fate specification, how cellular changes mediate morphogenesis of the lymphatic tree remains to be elucidated. This study will combine cell biology and developmental genetics approaches using mouse and zebrafish transgenic li ....Deciphering the cellular functions of caveolae that govern lymphatic vascular development. Lymphatic vessels play crucial roles in tissue fluid homeostasis, immunity, and fatty acid transport. Despite our recent understanding of genetic pathways that modulate lymphatic cell fate specification, how cellular changes mediate morphogenesis of the lymphatic tree remains to be elucidated. This study will combine cell biology and developmental genetics approaches using mouse and zebrafish transgenic lines that label lymphatic endothelial cells to investigate the role of caveolae proteins in the construction of the lymphatic vascular network. This project aims to improve our fundamental understanding of the processes that govern vascular system assembly and will broaden basic knowledge of organ morphogenesis. Read moreRead less
The cellular basis of branching morphogenesis during kidney development. This project aims to study the process of branching morphogenesis which drives the development of the kidney. Previous studies group have demonstrated, in general terms, how branching progresses during gestation. However, little is known about the fundamental cellular events which trigger or characterise this basic developmental process. This project expects to provide deep insights into the cellular basis of tissue and org ....The cellular basis of branching morphogenesis during kidney development. This project aims to study the process of branching morphogenesis which drives the development of the kidney. Previous studies group have demonstrated, in general terms, how branching progresses during gestation. However, little is known about the fundamental cellular events which trigger or characterise this basic developmental process. This project expects to provide deep insights into the cellular basis of tissue and organ development. In studying this process the project should provide critical insights into how cells act, individually and collectively, to build tissues.Read moreRead less