The mechanochemical basis of cell polarity. This project aims to study how epithelial cells initiate polarisation, a major question in biology that conventional biochemical, cell biological and genetic approaches have not answered. This project will investigate the mechanochemical basis of symmetry breaking in the cellular cortex, a thin layer of actomyosin filaments underneath the plasma membrane, and how this forms signalling zones. Understanding polarity is expected to improve epithelia manip ....The mechanochemical basis of cell polarity. This project aims to study how epithelial cells initiate polarisation, a major question in biology that conventional biochemical, cell biological and genetic approaches have not answered. This project will investigate the mechanochemical basis of symmetry breaking in the cellular cortex, a thin layer of actomyosin filaments underneath the plasma membrane, and how this forms signalling zones. Understanding polarity is expected to improve epithelia manipulation in disciplines from tissue engineering to regenerative biology and reveal how epithelial architecture and physiology are generated.Read moreRead less