Small is beautiful: Did gene-rich regions of mammal chromosomes evolve from microchromosomes? Most birds and reptile genomes feature many tiny microchromosomes. These are not junk, as previously thought, but contain most of the genes. Mammals lack microchromosomes, but contain gene-rich regions with similar attributes. We suggest that microchromosomes originated by genome duplication, and evolved into the gene-rich regions of mammalian chromosomes. We will test this hypothesis by comparing seque ....Small is beautiful: Did gene-rich regions of mammal chromosomes evolve from microchromosomes? Most birds and reptile genomes feature many tiny microchromosomes. These are not junk, as previously thought, but contain most of the genes. Mammals lack microchromosomes, but contain gene-rich regions with similar attributes. We suggest that microchromosomes originated by genome duplication, and evolved into the gene-rich regions of mammalian chromosomes. We will test this hypothesis by comparing sequences and genes in microchromosomes of birds, reptiles and monotremes. This will clarify the origin and evolution of the ?microgenome?, establish its suitability as a model for vertebrate genome organisation, and demonstrate whether microchromosomes are the ancestors of the gene-rich regions of mammalian chromosomes.Read moreRead less
Genetic control of floral architecture. Different flowers have different designs, and so the design must ultimately be controlled by genes. We have identified a gene that keeps sepals separate, and promotes the initiation of petals. We think it does this by a novel growth suppression mechanism, and will now deduce its molecular and cellular basis. This will help maintain Australia's strength in fundamental plant biology. Also, by understanding how sepals and petals arise in a model laboratory sp ....Genetic control of floral architecture. Different flowers have different designs, and so the design must ultimately be controlled by genes. We have identified a gene that keeps sepals separate, and promotes the initiation of petals. We think it does this by a novel growth suppression mechanism, and will now deduce its molecular and cellular basis. This will help maintain Australia's strength in fundamental plant biology. Also, by understanding how sepals and petals arise in a model laboratory species, we can generalise for many species, including economic plants. Thus it may be possible to make designer crops through targeted genetic changes to their floral structure.Read moreRead less
Control of plant organ development by the PETAL LOSS gene of Arabidopsis. We have discovered a new gene in the model laboratory plant Arabidopsis thaliana that is involved in sepal and petal development. It encodes a transcription factor that apparently acts by repressing growth in the inter-sepal zone of flowers where petals arise. We now aim to determine how this growth suppression occurs, and whether it extends to leaves where the gene is also expressed. Control of the initiation and sculptur ....Control of plant organ development by the PETAL LOSS gene of Arabidopsis. We have discovered a new gene in the model laboratory plant Arabidopsis thaliana that is involved in sepal and petal development. It encodes a transcription factor that apparently acts by repressing growth in the inter-sepal zone of flowers where petals arise. We now aim to determine how this growth suppression occurs, and whether it extends to leaves where the gene is also expressed. Control of the initiation and sculpturing of plant organs by site-specific inhibition of growth is a newly discovered mechanism that may be useful in manipulating plant architecture.Read moreRead less
Understanding how auxin and dorsoventral patterning are coordinated in plants. This study will help reveal for the first time how the outgrowth of leaves, flowers and floral organs is coordinated by tissue patterning genes and the plant growth hormone auxin. All plants grow in this way, and our findings, made using a model laboratory plant, will be applicable to crop species as well. Thus we will both expand our core knowledge of how multicellular organisms are constructed, and also generate pos ....Understanding how auxin and dorsoventral patterning are coordinated in plants. This study will help reveal for the first time how the outgrowth of leaves, flowers and floral organs is coordinated by tissue patterning genes and the plant growth hormone auxin. All plants grow in this way, and our findings, made using a model laboratory plant, will be applicable to crop species as well. Thus we will both expand our core knowledge of how multicellular organisms are constructed, and also generate possibilities for modifying the patterns of leaf and flower development in agricultural and horticultural species. Crops with larger leaves, or flowers of different structure, may result.Read moreRead less
Molecular and genetic analysis of epigenetic components in a model plant. Australia is a major exporter of agricultural food crops thus producers must maintain their competitive advantage in order to compete on the world stage. Food crops unfortunately have large, complex genomes that are not sequenced and a generation time of months that makes research outcomes slow to achieve. This project proposes to utilise a model plant that has a small completely sequenced genome and a short generation tim ....Molecular and genetic analysis of epigenetic components in a model plant. Australia is a major exporter of agricultural food crops thus producers must maintain their competitive advantage in order to compete on the world stage. Food crops unfortunately have large, complex genomes that are not sequenced and a generation time of months that makes research outcomes slow to achieve. This project proposes to utilise a model plant that has a small completely sequenced genome and a short generation time making it ideal to study the fundamental biological process of RNA silencing. Discoveries and outcomes from this project may have the potential to benefit Australian crops, ecosystems and human health.Read moreRead less
Doing state-building better? Practising ‘hybridity’ in Melanesia. Australia is engaged in programs that draw upon local socio-political practices and institutions to assist its efforts to stabilise and build states in Melanesia, referred to as a ‘hybridity’ approach. Australia has successfully restored stability in its immediate region, Melanesia, but its attempts to build stable liberal democracies have had modest results. This project will advance policy understandings to improve the efficacy ....Doing state-building better? Practising ‘hybridity’ in Melanesia. Australia is engaged in programs that draw upon local socio-political practices and institutions to assist its efforts to stabilise and build states in Melanesia, referred to as a ‘hybridity’ approach. Australia has successfully restored stability in its immediate region, Melanesia, but its attempts to build stable liberal democracies have had modest results. This project will advance policy understandings to improve the efficacy of Australia’s state-building efforts and promote social cohesion and stability in our neighbourhood. This will potentially encourage local self-reliance in Melanesia, reducing dependence on Australia’s development assistance.Read moreRead less
Locating LGBTIQ+ youth in the archive: Telling new stories for belonging. This project aims to produce the first study of LGBTIQ+ youth in Australia’s past and investigate what these histories mean to LGBTIQ+ youth today. We will generate new knowledge of Australian LGBTIQ+ history and links between historical knowledge and wellbeing in relation to LGBTIQ+ youth. Working with LGBTIQ+ youth we will also develop new archival storytelling techniques, theorising archives as ‘laboratories of belongin ....Locating LGBTIQ+ youth in the archive: Telling new stories for belonging. This project aims to produce the first study of LGBTIQ+ youth in Australia’s past and investigate what these histories mean to LGBTIQ+ youth today. We will generate new knowledge of Australian LGBTIQ+ history and links between historical knowledge and wellbeing in relation to LGBTIQ+ youth. Working with LGBTIQ+ youth we will also develop new archival storytelling techniques, theorising archives as ‘laboratories of belonging’. In doing so, the project forges links between cultural studies of storytelling, LGBTIQ+ youth studies and Australian history. Benefits include innovations in reparative historical methodologies, new resources for the GLAM, youth and education sectors and improvements in LGBTIQ+ youth wellbeing.Read moreRead less
Resilient humanitarianism: the League of Red Cross Societies, 1919-1991. This project aims to advance the concept of resilient humanitarianism through a historical investigation of one humanitarian body, the League of Red Cross Societies, from its inception to the end of the Cold War. Global humanitarian crises abound due to ongoing conflict and natural disasters but nation states, bodies such as the United Nations and humanitarian organisations seem incapable of offering lasting solutions to in ....Resilient humanitarianism: the League of Red Cross Societies, 1919-1991. This project aims to advance the concept of resilient humanitarianism through a historical investigation of one humanitarian body, the League of Red Cross Societies, from its inception to the end of the Cold War. Global humanitarian crises abound due to ongoing conflict and natural disasters but nation states, bodies such as the United Nations and humanitarian organisations seem incapable of offering lasting solutions to intractable situations. This project will use rarely accessed archives and an interdisciplinary approach to investigate the evolution of humanitarianism, voluntary action and global civil society during the 20th century. This historical analysis can inform humanitarian policy, debates and practice of the present and future.Read moreRead less
Water and the making of urban Australia since 1900. This project aims to produce new understandings of both the historical drivers of today’s urban water systems, and how these systems have impacted on human and ecological welfare. This will be achieved through the first integrated and comparative historical study of the provision, use and cultures of water in Australia’s five largest cities from 1900 to the present. Such historical knowledge is critical at a time when the water systems of Austr ....Water and the making of urban Australia since 1900. This project aims to produce new understandings of both the historical drivers of today’s urban water systems, and how these systems have impacted on human and ecological welfare. This will be achieved through the first integrated and comparative historical study of the provision, use and cultures of water in Australia’s five largest cities from 1900 to the present. Such historical knowledge is critical at a time when the water systems of Australia’s largest cities are under growing pressure from environmental change and population growth. Project findings will inform the development of policies and practices that produce sustainable, equitable urban water systems.Read moreRead less
Heritage and Reconciliation. This project will re-conceptualise heritage from a standpoint of reconciliation. In doing so, it will generate new understandings about how heritage and its management can contribute to reconciliation processes. The project will combine Aboriginal, Maori and Western intellectual traditions in order to advance theoretical understandings of heritage and to examine its reconstructive power. It will produce models for practical implementation, including new conservation ....Heritage and Reconciliation. This project will re-conceptualise heritage from a standpoint of reconciliation. In doing so, it will generate new understandings about how heritage and its management can contribute to reconciliation processes. The project will combine Aboriginal, Maori and Western intellectual traditions in order to advance theoretical understandings of heritage and to examine its reconstructive power. It will produce models for practical implementation, including new conservation and management protocols. The project's investigation of a new approach to heritage has the potential for profound social benefit.Read moreRead less